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    SRPRB SRP receptor subunit beta [ Homo sapiens (human) ]

    Gene ID: 58477, updated on 7-Apr-2024

    Summary

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    Official Symbol
    SRPRBprovided by HGNC
    Official Full Name
    SRP receptor subunit betaprovided by HGNC
    Primary source
    HGNC:HGNC:24085
    See related
    Ensembl:ENSG00000144867 MIM:616883; AllianceGenome:HGNC:24085
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APMCF1; SR-beta
    Summary
    The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 18.4), testis (RPKM 17.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    3q22.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (133784023..133828574)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (136529221..136573768)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (133502867..133547418)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene transferrin Neighboring gene RNA, 5S ribosomal pseudogene 140 Neighboring gene uncharacterized LOC105374116 Neighboring gene ACSL3 pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chr3:133513906-133514490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20555 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20557 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20558 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20559 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:133554421-133554601 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:133558716-133559216 Neighboring gene NANOG hESC enhancer GRCh37_chr3:133573718-133574219 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:133576178-133576792 Neighboring gene RAB6B, member RAS oncogene family Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20560 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:133661421-133662009 Neighboring gene Sharpr-MPRA regulatory region 14374 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr3:133667965-133668933 Neighboring gene chromosome 3 putative open reading frame 36 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:133674467-133674998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:133674999-133675528 Neighboring gene solute carrier organic anion transporter family member 2A1 Neighboring gene Sharpr-MPRA regulatory region 8475 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:133748764-133749264

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Isolation of a novel member of small G protein superfamily and its expression in colon cancer. Yan W, et al. World J Gastroenterol, 2003 Aug. PMID 12918107, Free PMC Article
    2. The ribosome regulates the GTPase of the beta-subunit of the signal recognition particle receptor. Bacher G, et al. J Cell Biol, 1999 Aug 23. PMID 10459008, Free PMC Article
    3. SERP1 is a novel marker of poor prognosis in pancreatic ductal adenocarcinoma patients via anti-apoptosis and regulating SRPRB/NF-κB axis. Ma Q, et al. Int J Oncol, 2017 Oct. PMID 28902358, Free PMC Article
    4. Subcellular localization of APMCF1 and its biological significance of expression pattern in normal and malignant human tissues. Zhang Y, et al. J Exp Clin Cancer Res, 2009 Aug 9. PMID 19664239, Free PMC Article
    5. The association between alcohol metabolism and genetic variants of ADH1A, SRPRB, and PGM1 in Korea. Lee YJ, et al. Alcohol, 2019 Sep. PMID 31002879

    See all (120) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Variation in SRPRB was associated with lower blood alcohol content in Korean subjects, suggesting likely involvement in alcohol metabolism and possible association with the development of alcohol-related diseases in Korea.
      Title: The association between alcohol metabolism and genetic variants of ADH1A, SRPRB, and PGM1 in Korea.
    2. Results show that SRPRB promotes cell apoptosis through NF-kappaB activation. Its expression is regulated by SERP1 in pancreatic ductal adenocarcinoma.
      Title: SERP1 is a novel marker of poor prognosis in pancreatic ductal adenocarcinoma patients via anti-apoptosis and regulating SRPRB/NF-κB axis.
    3. APMCF1 participates at least partially in cell cycle regulation through regulating genes such as p21 and TIMP3.
      Title: Introduction of G1 phase arrest in Human Hepatocellular carcinoma cells (HHCC) by APMCF1 gene transfection through the down-regulation of TIMP3 and up-regulation of the CDK inhibitors p21.
    4. APMCF1 may be the gene coding human signal recognition particle receptor beta and belongs to the small-G protein superfamily. Its strong expression pattern in colon cancer suggests it may play a role in colon cancer development.
      Title: Isolation of a novel member of small G protein superfamily and its expression in colon cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies two loci strongly affecting transferrin glycosylation.
    EBI GWAS Catalog
    Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify signal recognition particle receptor B subunit (SRPRB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify signal recognition particle receptor B subunit (SRPRB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify signal recognition particle receptor B subunit (SRPRB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify signal recognition particle receptor B subunit (SRPRB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of signal recognition particle receptor complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of signal recognition particle receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    signal recognition particle receptor subunit beta
    Names
    SRP receptor beta subunit
    signal recognition particle receptor, B subunit
    signal recognition particle receptor, beta subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379313.1 → NP_001366242.1  signal recognition particle receptor subunit beta

      Status: REVIEWED

      Description
      Transcript Variant: Variants 1 and 3 encode the same protein.
      Source sequence(s)
      AC080128
      Consensus CDS
      CCDS3081.1
      UniProtKB/Swiss-Prot
      Q6P595, Q8N2D8, Q9Y5M8
      UniProtKB/TrEMBL
      D3DND2, Q549N5
      Related
      ENSP00000503923.1, ENST00000678299.1
      Conserved Domains (1) summary
      pfam09439
      Location:62 → 241
      SRPRB; Signal recognition particle receptor beta subunit

    2. NM_021203.4 → NP_067026.3  signal recognition particle receptor subunit beta

      See identical proteins and their annotated locations for NP_067026.3

      Status: REVIEWED

      Description
      Transcript Variant: Variants 1 and 3 encode the same protein.
      Source sequence(s)
      AC080128
      Consensus CDS
      CCDS3081.1
      UniProtKB/Swiss-Prot
      Q6P595, Q8N2D8, Q9Y5M8
      UniProtKB/TrEMBL
      D3DND2, Q549N5
      Related
      ENSP00000418401.1, ENST00000466490.7
      Conserved Domains (1) summary
      pfam09439
      Location:62 → 241
      SRPRB; Signal recognition particle receptor beta subunit

    RNA

    1. NR_163491.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC080128

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      133784023..133828574
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      136529221..136573768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y5M8.3 GenPept UniProtKB/Swiss-Prot:Q9Y5M8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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