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    Asb4 ankyrin repeat and SOCS box-containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 65255, updated on 2-May-2024

    Summary

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    Official Symbol
    Asb4provided by MGI
    Official Full Name
    ankyrin repeat and SOCS box-containing 4provided by MGI
    Primary source
    MGI:MGI:1929751
    See related
    Ensembl:ENSMUSG00000042607 AllianceGenome:MGI:1929751
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    8430401O13Rik
    Summary
    Enables ubiquitin protein ligase activity and ubiquitin protein ligase binding activity. Involved in positive regulation of vasculogenesis and protein autoubiquitination. Part of Cul2-RING ubiquitin ligase complex and Cul5-RING ubiquitin ligase complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; extraembryonic component; and limb. Used to study pre-eclampsia. Orthologous to human ASB4 (ankyrin repeat and SOCS box containing 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E11.5 (RPKM 13.8), limb E14.5 (RPKM 13.0) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 A1; 6 1.99 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (5383386..5433022)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (5383386..5433022)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3642 Neighboring gene paraoxonase 2 Neighboring gene STARR-seq mESC enhancer starr_15035 Neighboring gene STARR-positive B cell enhancer ABC_E8094 Neighboring gene STARR-seq mESC enhancer starr_15037 Neighboring gene STARR-seq mESC enhancer starr_15042 Neighboring gene predicted gene, 38762 Neighboring gene STARR-seq mESC enhancer starr_15044 Neighboring gene STARR-seq mESC enhancer starr_15047 Neighboring gene STARR-seq mESC enhancer starr_15048 Neighboring gene STARR-seq mESC enhancer starr_15049 Neighboring gene pyruvate dehydrogenase kinase, isoenzyme 4 Neighboring gene STARR-seq mESC enhancer starr_15050 Neighboring gene predicted gene, 34470

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nicotinamide benefits both mothers and pups in two contrasting mouse models of preeclampsia. Li F, et al. Proc Natl Acad Sci U S A, 2016 Nov 22. PMID 27821757, Free PMC Article
    2. Regulation of ankyrin repeat and suppressor of cytokine signalling box protein 4 expression in the immortalized murine endothelial cell lines MS1 and SVR: a role for tumour necrosis factor alpha and oxygen. Bode M, et al. Cell Biochem Funct, 2011 Jun. PMID 21506136, Free PMC Article
    3. Stage-specific expression of ankyrin and SOCS box protein-4 (Asb-4) during spermatogenesis. Kim SK, et al. Mol Cells, 2008 Apr 30. PMID 18414003
    4. Genetic control of levels of murine kidney glucuronidase mRNA in response to androgen. Palmer R, et al. Proc Natl Acad Sci U S A, 1983 Dec. PMID 6584873, Free PMC Article
    5. Expression of ankyrin repeat and suppressor of cytokine signaling box protein 4 (Asb-4) in proopiomelanocortin neurons of the arcuate nucleus of mice produces a hyperphagic, lean phenotype. Li JY, et al. Endocrinology, 2010 Jan. PMID 19934378, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of imprinted gene Asb4 was unregulated in haploid androgenetic/gynogenetic blastocysts.
      Title: Analysis of imprinted gene expression and implantation in haploid androgenetic mouse embryos.
    2. In functional endothelial co-culture assays, JAR cells ectopically expressing ASB4 increased endothelial cell turnover and stabilized endothelial tube formation, both of which are hallmarks of vascular differentiation within the placenta.
      Title: The ubiquitin ligase ASB4 promotes trophoblast differentiation through the degradation of ID2.
    3. The interaction of Asb-4 with IRS4 in cell lines mediates the degradation of IRS4 and decreases insulin signaling.
      Title: Ankyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation.
    4. Tumor necrosis factor alpha upregulates ankyrin repeat and suppressor of cytokine signalling box protein 4 expression.
      Title: Regulation of ankyrin repeat and suppressor of cytokine signalling box protein 4 expression in the immortalized murine endothelial cell lines MS1 and SVR: a role for tumour necrosis factor alpha and oxygen.
    5. Asb-4 is a key regulatory protein in the central nervous system, involved in the control of feeding behavior and metabolic rate.
      Title: Expression of ankyrin repeat and suppressor of cytokine signaling box protein 4 (Asb-4) in proopiomelanocortin neurons of the arcuate nucleus of mice produces a hyperphagic, lean phenotype.
    6. These results suggest that ASB-4 plays pivotal roles in mammalian testis development and spermatogenesis.
      Title: Stage-specific expression of ankyrin and SOCS box protein-4 (Asb-4) during spermatogenesis.
    7. Asb4 has been identified as an imprinted gene by high-throughput screening using RIKEN cDNA microarray.
      Title: Asb4, Ata3, and Dcn are novel imprinted genes identified by high-throughput screening using RIKEN cDNA microarray.
    8. The present study demonstrates that Asb-4 interacts with GPS1 and inhibits JNK activity.
      Title: Ankyrin repeat and SOCS box containing protein 4 (Asb-4) interacts with GPS1 (CSN1) and inhibits c-Jun NH2-terminal kinase activity.
    9. Based on its differential expression, neuroanatomical distribution and colocalisation, we hypothesise that rat Asb-4 is a gene involved in energy homeostasis.
      Title: Arcuate nucleus transcriptome profiling identifies ankyrin repeat and suppressor of cytokine signalling box-containing protein 4 as a gene regulated by fasting in central nervous system feeding circuits.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of vasculogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Cul2-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul5-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Cul5-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 4
    Names
    ASB-4
    ankyrin repeat and SOCS box-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355662.1 → NP_001342591.1  ankyrin repeat and SOCS box protein 4

      Status: VALIDATED

      Source sequence(s)
      AC023285, AC119865
      Consensus CDS
      CCDS19901.1
      UniProtKB/Swiss-Prot
      Q3UZE1, Q3V070, Q9WV71
      Conserved Domains (3) summary
      cd00204
      Location:77 → 191
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03723
      Location:379 → 426
      SOCS_ASB4_ASB18; SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the ...
      sd00045
      Location:77 → 104
      ANK; ANK repeat [structural motif]

    2. NM_023048.5 → NP_075535.1  ankyrin repeat and SOCS box protein 4

      See identical proteins and their annotated locations for NP_075535.1

      Status: VALIDATED

      Source sequence(s)
      AC119865, BC046819
      Consensus CDS
      CCDS19901.1
      UniProtKB/Swiss-Prot
      Q3UZE1, Q3V070, Q9WV71
      Related
      ENSMUSP00000040331.6, ENSMUST00000043294.12
      Conserved Domains (3) summary
      cd00204
      Location:77 → 191
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03723
      Location:379 → 426
      SOCS_ASB4_ASB18; SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the ...
      sd00045
      Location:77 → 104
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      5383386..5433022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WV71.1 GenPept UniProtKB/Swiss-Prot:Q9WV71

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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