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    Stoml1 stomatin-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 69106, updated on 14-May-2024

    Summary

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    Official Symbol
    Stoml1provided by MGI
    Official Full Name
    stomatin-like 1provided by MGI
    Primary source
    MGI:MGI:1916356
    See related
    Ensembl:ENSMUSG00000032333 AllianceGenome:MGI:1916356
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SLP1; STORP; UNC24; WPB72; 1810015E19Rik
    Summary
    Enables ion channel inhibitor activity. Acts upstream of or within SMAD protein signal transduction; cellular response to leukemia inhibitory factor; and negative regulation of acid-sensing ion channel activity. Located in cytoplasmic vesicle and plasma membrane. Orthologous to human STOML1 (stomatin like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 21.3), whole brain E14.5 (RPKM 15.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Stoml1 in Genome Data Viewer
    Location:
    9 B; 9 31.63 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (58160443..58169807)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (58253160..58262524)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10552 Neighboring gene immunoglobulin superfamily containing leucine-rich repeat 2 Neighboring gene microRNA 6385 Neighboring gene promyelocytic leukemia Neighboring gene STARR-positive B cell enhancer ABC_E2891 Neighboring gene STARR-positive B cell enhancer ABC_E5071 Neighboring gene STARR-positive B cell enhancer ABC_E9764 Neighboring gene STARR-positive B cell enhancer ABC_E5072 Neighboring gene STARR-positive B cell enhancer ABC_E3836 Neighboring gene STARR-positive B cell enhancer ABC_E5073 Neighboring gene STARR-positive B cell enhancer ABC_E3837 Neighboring gene STARR-seq mESC enhancer starr_24273 Neighboring gene lysyl oxidase-like 1 Neighboring gene predicted gene, 53526

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Subunit-specific inhibition of acid sensing ion channels by stomatin-like protein 1. Kozlenkov A, et al. J Physiol, 2014 Feb 15. PMID 24247984, Free PMC Article
    2. TGF-β/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos. Redshaw N, et al. PLoS One, 2013. PMID 23390484, Free PMC Article
    3. Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice. Fenske TS, et al. Cancer Res, 2006 May 15. PMID 16707424
    4. miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, et al. FASEB J, 2010 Sep. PMID 20439489
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. STOML1 modulates ASIC1a and ASIC3 in DRG neurons.
      Title: Subunit-specific inhibition of acid sensing ion channels by stomatin-like protein 1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC13700

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ion channel inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    stomatin-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026942.3 → NP_081218.3  stomatin-like protein 1

      See identical proteins and their annotated locations for NP_081218.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AC160976, AK045820, BE947366, CJ151482
      Consensus CDS
      CCDS23241.1
      UniProtKB/Swiss-Prot
      Q8BLA3, Q8CI66
      UniProtKB/TrEMBL
      A0A0B4J1F1
      Related
      ENSMUSP00000034883.6, ENSMUST00000034883.7
      Conserved Domains (3) summary
      smart00244
      Location:77 → 217
      PHB; prohibitin homologues
      cd13436
      Location:94 → 224
      SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
      pfam02036
      Location:305 → 396
      SCP2; SCP-2 sterol transfer family

    RNA

    1. NR_028146.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate exon in the coding region. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC160976, BE947366
      Related
      ENSMUST00000216877.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      58160443..58169807
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511402.4 → XP_006511465.1  stomatin-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006511465.1

      Conserved Domains (2) summary
      cd13436
      Location:7 → 137
      SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
      pfam02036
      Location:225 → 309
      SCP2; SCP-2 sterol transfer family

    2. XM_030244558.2 → XP_030100418.1  stomatin-like protein 1 isoform X1

      Conserved Domains (2) summary
      cd13436
      Location:7 → 137
      SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
      pfam02036
      Location:225 → 309
      SCP2; SCP-2 sterol transfer family

    3. XM_006511404.4 → XP_006511467.1  stomatin-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006511467.1

      Conserved Domains (2) summary
      cd13436
      Location:7 → 137
      SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
      pfam02036
      Location:225 → 309
      SCP2; SCP-2 sterol transfer family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CI66.1 GenPept UniProtKB/Swiss-Prot:Q8CI66

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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