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    Ankrd27 ankyrin repeat domain 27 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361555, updated on 13-Apr-2024

    Summary

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    Symbol
    Ankrd27provided by RGD
    Full Name
    ankyrin repeat domain 27provided by RGD
    Primary source
    RGD:1307106
    See related
    Ensembl:ENSRNOG00000052814 AllianceGenome:RGD:1307106
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables SNARE binding activity. Involved in positive regulation of neuron projection development. Predicted to be located in lysosome and melanosome. Predicted to be active in cytoplasmic vesicle; neuron projection; and plasma membrane. Human ortholog(s) of this gene implicated in eosinophilic esophagitis. Orthologous to human ANKRD27 (ankyrin repeat domain 27). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 205.1), Kidney (RPKM 148.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q21
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (97387997..97440501)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (88251216..88303615)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (91857048..91958763)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene nudix hydrolase 19 Neighboring gene regulator of G protein signaling 9 binding protein Neighboring gene programmed cell death 5 Neighboring gene dpy-19 like C-mannosyltransferase 3 Neighboring gene uncharacterized LOC134483099

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Evaluation of genotoxic potential of neurotoxin anatoxin-a with the use of umuC test. Sieroslawska A, et al. Neuro Endocrinol Lett, 2010. PMID 21187829
    2. VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surface. Hesketh GG, et al. Dev Cell, 2014 Jun 9. PMID 24856514, Free PMC Article
    3. Varp is a novel Rab32/38-binding protein that regulates Tyrp1 trafficking in melanocytes. Tamura K, et al. Mol Biol Cell, 2009 Jun. PMID 19403694, Free PMC Article
    4. The Rab21-GEF activity of Varp, but not its Rab32/38 effector function, is required for dendrite formation in melanocytes. Ohbayashi N, et al. Mol Biol Cell, 2012 Feb. PMID 22171327, Free PMC Article
    5. GWAS identifies four novel eosinophilic esophagitis loci. Sleiman PM, et al. Nat Commun, 2014 Nov 19. PMID 25407941, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNARE binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables SNARE binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in early endosome to late endosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome to melanosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of SNARE complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in melanosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in transport vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in tubular endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in tubular endosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 27
    Names
    ankyrin repeat domain 27 (VPS9 domain)
    ankyrin repeat domain-containing protein 27-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271264.1 → NP_001258193.1  ankyrin repeat domain-containing protein 27

      Status: VALIDATED

      Source sequence(s)
      CO574455, JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K7U7
      Related
      ENSRNOP00000074354.2, ENSRNOT00000081465.2
      Conserved Domains (4) summary
      PHA02874
      Location:387 → 607
      PHA02874; ankyrin repeat protein; Provisional
      sd00045
      Location:743 → 774
      ANK; ANK repeat [structural motif]
      cl19569
      Location:264 → 363
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      pfam12796
      Location:781 → 873
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      97387997..97440501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589356.3 → XP_017444845.2  ankyrin repeat domain-containing protein 27 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K7U7
      Conserved Domains (4) summary
      PHA02874
      Location:387 → 607
      PHA02874; ankyrin repeat protein; Provisional
      sd00045
      Location:743 → 774
      ANK; ANK repeat [structural motif]
      cl19569
      Location:264 → 363
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      pfam12796
      Location:781 → 873
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_063266553.1 → XP_063122623.1  ankyrin repeat domain-containing protein 27 isoform X2

    3. XM_039082080.2 → XP_038938008.1  ankyrin repeat domain-containing protein 27 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZNY3
      Conserved Domains (4) summary
      PHA02874
      Location:327 → 547
      PHA02874; ankyrin repeat protein; Provisional
      sd00045
      Location:683 → 714
      ANK; ANK repeat [structural motif]
      cl19569
      Location:204 → 303
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      pfam12796
      Location:721 → 813
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_039082076.2 → XP_038938004.1  ankyrin repeat domain-containing protein 27 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZNY3
      Conserved Domains (4) summary
      PHA02874
      Location:327 → 547
      PHA02874; ankyrin repeat protein; Provisional
      sd00045
      Location:683 → 714
      ANK; ANK repeat [structural motif]
      cl19569
      Location:204 → 303
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      pfam12796
      Location:721 → 813
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_017589358.3 → XP_017444847.2  ankyrin repeat domain-containing protein 27 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZNY3
      Conserved Domains (4) summary
      PHA02874
      Location:327 → 547
      PHA02874; ankyrin repeat protein; Provisional
      sd00045
      Location:683 → 714
      ANK; ANK repeat [structural motif]
      cl19569
      Location:204 → 303
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      pfam12796
      Location:721 → 813
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version

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