U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    REPIN1 replication initiator 1 [ Homo sapiens (human) ]

    Gene ID: 29803, updated on 2-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    REPIN1provided by HGNC
    Official Full Name
    replication initiator 1provided by HGNC
    Primary source
    HGNC:HGNC:17922
    See related
    Ensembl:ENSG00000214022 MIM:619039; AllianceGenome:HGNC:17922
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AP4; RIP60; ZNF464; Zfp464
    Summary
    Enables RNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of glucose import and regulation of fatty acid transport. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon (RPKM 20.6), spleen (RPKM 16.1) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See REPIN1 in Genome Data Viewer
    Location:
    7q36.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (150368096..150374039)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (151546435..151552378)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150065185..150071128)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18774 Neighboring gene uncharacterized LOC107986858 Neighboring gene retinoic acid receptor responder 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:150044724-150044956 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18775 Neighboring gene REPIN1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26823 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150065484-150066288 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150066289-150067094 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150067095-150067899 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26825 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26826 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18778 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26827 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150078931-150079888 Neighboring gene ZNF775 antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150080845-150081800 Neighboring gene zinc finger protein 775 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150083270-150083842 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150083843-150084413 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150085648-150086246 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150096281-150096868 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150096869-150097456 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150097787-150098311 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150098312-150098835 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:150098842-150099517 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150099518-150100192 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150100193-150100867 Neighboring gene zinc finger domain-containing protein LOC728743 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18779 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150103235-150103743 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26828

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A Human REPIN1 Gene Variant: Genetic Risk Factor for the Development of Nonalcoholic Fatty Liver Disease. Abshagen K, et al. Clin Transl Gastroenterol, 2020 Jan. PMID 31922994, Free PMC Article
    2. Metabolic effects of genetic variation in the human REPIN1 gene. Krüger J, et al. Int J Obes (Lond), 2019 Apr. PMID 29915365
    3. Crosstalk of AP4 and TGFβ receptor signaling in NSCLC. Wang W, et al. Tumour Biol, 2015 Jan. PMID 25266805
    4. Condensation by DNA looping facilitates transfer of large DNA molecules into mammalian cells. Montigny WJ, et al. Nucleic Acids Res, 2001 May 1. PMID 11328883, Free PMC Article
    5. The dhfr oribeta-binding protein RIP60 contains 15 zinc fingers: DNA binding and looping by the central three fingers and an associated proline-rich region. Houchens CR, et al. Nucleic Acids Res, 2000 Jan 15. PMID 10606657, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. REPIN1 regulates iron metabolism and osteoblast apoptosis in osteoporosis.
      Title: REPIN1 regulates iron metabolism and osteoblast apoptosis in osteoporosis.
    2. Overexpression of miR-127 Predicts Poor Prognosis and Contributes to the Progression of Papillary Thyroid Cancer by Targeting REPIN1.
      Title: Overexpression of miR-127 Predicts Poor Prognosis and Contributes to the Progression of Papillary Thyroid Cancer by Targeting REPIN1.
    3. A Human REPIN1 Gene Variant: Genetic Risk Factor for the Development of Nonalcoholic Fatty Liver Disease.
      Title: A Human REPIN1 Gene Variant: Genetic Risk Factor for the Development of Nonalcoholic Fatty Liver Disease.
    4. data suggest that genetic variation in human REPIN1 plays a role in glucose and lipid metabolism by differentially affecting the expression of REPIN1 target genes including glucose and fatty acid transporters
      Title: Metabolic effects of genetic variation in the human REPIN1 gene.
    5. Increased expression of hsa-mir-127 and decreased expression of REPIN1 were both associated with poor overall survival
      Title: Hsa-mir-127 impairs survival of patients with glioma and promotes proliferation, migration and invasion of cancerous cells by modulating replication initiator 1.
    6. AP4 and LAPTM4B are highly coexpressed in hepatocellular carcinoma tissues, and their coexpression may be a marker of poor prognosis.
      Title: AP4 positively regulates LAPTM4B to promote hepatocellular carcinoma growth and metastasis, while reducing chemotherapy sensitivity.
    7. Results show that breast cancer cells underwent epithelial-mesenchymal transition when AP4 was upregulated, and that AP4 regulated p53 expression level suggesting AP4 can regulate cell migration via the activity of p53.
      Title: AP4 activates cell migration and EMT mediated by p53 in MDA-MB-231 breast carcinoma cells.
    8. AP4 is transcriptionally activated by TGFB1 to inhibit phosphorylation of SMAD2 as a negative regulator of an activated TGFB receptor signaling on cell growth inhibition in non-small cell lung cancer
      Title: Crosstalk of AP4 and TGFβ receptor signaling in NSCLC.
    9. there is a p53-induced double-negative feedback loop involving miR-15a/16-1 and AP4 that stabilizes epithelial and mesenchymal states, respectively, which may determine metastatic prowess in colorectal cancer
      Title: p53-induced miR-15a/16-1 and AP4 form a double-negative feedback loop to regulate epithelial-mesenchymal transition and metastasis in colorectal cancer.
    10. a potential role for Repin1 as regulator of adipocyte size was shown.Repin1 seems to be involved in the regulation of genes involved in adipogenesis.
      Title: Repin1 maybe involved in the regulation of cell size and glucose transport in adipocytes.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

    Go to the top of the page Help

    Replication interactions

    Interaction Pubs
    Knockdown of replication initiator 1 (REPIN1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables chromatin insulator sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of fatty acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    replication initiator 1
    Names
    60 kDa origin-specific DNA-binding protein
    60 kDa replication initiation region protein
    ATT-binding protein
    DHFR oribeta-binding protein RIP60
    H_DJ0584D14.12
    replication initiation region protein (60kD)
    zinc finger protein 464 (RIP60)
    zinc finger protein AP4

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099695.2 → NP_001093165.1  replication initiator 1 isoform 3

      See identical proteins and their annotated locations for NP_001093165.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate segment, compared to variant 1, that results in the use of an upstream start codon. The predicted protein (isoform 3) has a distinct N-terminus compared to isoform 1. Variants 4 and 7-10 all encode the same isoform (3).
      Source sequence(s)
      AL046625, BC000363, CN386958
      Consensus CDS
      CCDS47745.1
      UniProtKB/Swiss-Prot
      Q9BWE0
      Related
      ENSP00000417291.2, ENST00000489432.7
      Conserved Domains (2) summary
      COG5048
      Location:290 → 597
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:518 → 538
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001099696.3 → NP_001093166.1  replication initiator 1 isoform 1

      See identical proteins and their annotated locations for NP_001093166.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 3, 5, 6, and 17-36 all encode the same isoform (1).
      Source sequence(s)
      AC005586, BC000363
      Consensus CDS
      CCDS43677.1
      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1
      Related
      ENSP00000407714.1, ENST00000444957.3
      Conserved Domains (2) summary
      COG5048
      Location:233 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001362745.2 → NP_001349674.1  replication initiator 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC005586, BC000363, CN386958
      Consensus CDS
      CCDS47745.1
      Conserved Domains (2) summary
      COG5048
      Location:290 → 597
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:518 → 538
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001362746.2 → NP_001349675.1  replication initiator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC005586, AK292670, BC000363, BX443182, DB158657
      Consensus CDS
      CCDS43677.1
      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1
      Conserved Domains (2) summary
      COG5048
      Location:233 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_001362747.2 → NP_001349676.1  replication initiator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      BC000363, CD675150, CX166683
      Consensus CDS
      CCDS43677.1
      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1
      Conserved Domains (2) summary
      COG5048
      Location:233 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001388037.1 → NP_001374966.1  replication initiator 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) encodes the longest isoform (4).
      Source sequence(s)
      AC005586
      Conserved Domains (2) summary
      COG5048
      Location:292 → 599
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:520 → 540
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. NM_001388038.1 → NP_001374967.1  replication initiator 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Consensus CDS
      CCDS47745.1
      Conserved Domains (2) summary
      COG5048
      Location:290 → 597
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:518 → 538
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. NM_001388039.1 → NP_001374968.1  replication initiator 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Consensus CDS
      CCDS47745.1
      Conserved Domains (2) summary
      COG5048
      Location:290 → 597
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:518 → 538
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. NM_001388040.1 → NP_001374969.1  replication initiator 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Consensus CDS
      CCDS47745.1
      Conserved Domains (2) summary
      COG5048
      Location:290 → 597
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:518 → 538
      ZF_C2H2; C2H2 Zn finger [structural motif]

    10. NM_001388041.1 → NP_001374970.1  replication initiator 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Conserved Domains (2) summary
      COG5048
      Location:289 → 596
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:517 → 537
      ZF_C2H2; C2H2 Zn finger [structural motif]

    11. NM_001388042.1 → NP_001374971.1  replication initiator 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Conserved Domains (2) summary
      COG5048
      Location:289 → 596
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:517 → 537
      ZF_C2H2; C2H2 Zn finger [structural motif]

    12. NM_001388043.1 → NP_001374972.1  replication initiator 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Conserved Domains (2) summary
      COG5048
      Location:289 → 596
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:517 → 537
      ZF_C2H2; C2H2 Zn finger [structural motif]

    13. NM_001388044.1 → NP_001374973.1  replication initiator 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Conserved Domains (2) summary
      COG5048
      Location:289 → 596
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:517 → 537
      ZF_C2H2; C2H2 Zn finger [structural motif]

    14. NM_001388045.1 → NP_001374974.1  replication initiator 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Conserved Domains (2) summary
      COG5048
      Location:289 → 596
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:517 → 537
      ZF_C2H2; C2H2 Zn finger [structural motif]

    15. NM_001388046.1 → NP_001374975.1  replication initiator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Consensus CDS
      CCDS43677.1
      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1
      Conserved Domains (2) summary
      COG5048
      Location:233 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    16. NM_001388047.1 → NP_001374976.1  replication initiator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Consensus CDS
      CCDS43677.1
      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1
      Conserved Domains (2) summary
      COG5048
      Location:233 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    17. NM_001388048.1 → NP_001374977.1  replication initiator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Consensus CDS
      CCDS43677.1
      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1
      Conserved Domains (2) summary
      COG5048
      Location:233 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    18. NM_001388049.1 → NP_001374978.1  replication initiator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Consensus CDS
      CCDS43677.1
      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1
      Conserved Domains (2) summary
      COG5048
      Location:233 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    19. NM_001388050.1 → NP_001374979.1  replication initiator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Consensus CDS
      CCDS43677.1
      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1
      Conserved Domains (2) summary
      COG5048
      Location:233 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    20. NM_001388051.1 → NP_001374980.1  replication initiator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Consensus CDS
      CCDS43677.1
      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1
      Conserved Domains (2) summary
      COG5048
      Location:233 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    21. NM_001388052.1 → NP_001374981.1  replication initiator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Consensus CDS
      CCDS43677.1
      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1
      Conserved Domains (2) summary
      COG5048
      Location:233 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    22. NM_001388053.1 → NP_001374982.1  replication initiator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Consensus CDS
      CCDS43677.1
      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1
      Conserved Domains (2) summary
      COG5048
      Location:233 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    23. NM_001388054.1 → NP_001374983.1  replication initiator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Consensus CDS
      CCDS43677.1
      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1
      Conserved Domains (2) summary
      COG5048
      Location:233 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    24. NM_001388055.1 → NP_001374984.1  replication initiator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Consensus CDS
      CCDS43677.1
      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1
      Conserved Domains (2) summary
      COG5048
      Location:233 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    25. NM_001388056.1 → NP_001374985.1  replication initiator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Consensus CDS
      CCDS43677.1
      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1
      Conserved Domains (2) summary
      COG5048
      Location:233 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    26. NM_001388057.1 → NP_001374986.1  replication initiator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Consensus CDS
      CCDS43677.1
      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1
      Conserved Domains (2) summary
      COG5048
      Location:233 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    27. NM_001388058.1 → NP_001374987.1  replication initiator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Consensus CDS
      CCDS43677.1
      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1
      Conserved Domains (2) summary
      COG5048
      Location:233 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    28. NM_001388059.1 → NP_001374988.1  replication initiator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Consensus CDS
      CCDS43677.1
      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1
      Conserved Domains (2) summary
      COG5048
      Location:233 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    29. NM_001388060.1 → NP_001374989.1  replication initiator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Consensus CDS
      CCDS43677.1
      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1
      Conserved Domains (2) summary
      COG5048
      Location:233 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    30. NM_001388061.1 → NP_001374990.1  replication initiator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Consensus CDS
      CCDS43677.1
      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1
      Conserved Domains (2) summary
      COG5048
      Location:233 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    31. NM_001388062.1 → NP_001374991.1  replication initiator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Consensus CDS
      CCDS43677.1
      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1
      Conserved Domains (2) summary
      COG5048
      Location:233 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    32. NM_001388063.1 → NP_001374992.1  replication initiator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Consensus CDS
      CCDS43677.1
      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1
      Conserved Domains (2) summary
      COG5048
      Location:233 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    33. NM_001388064.1 → NP_001374993.1  replication initiator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Consensus CDS
      CCDS43677.1
      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1
      Related
      ENSP00000388287.2, ENST00000425389.2
      Conserved Domains (2) summary
      COG5048
      Location:233 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    34. NM_001388065.1 → NP_001374994.1  replication initiator 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC005586
      Consensus CDS
      CCDS43677.1
      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1
      Conserved Domains (2) summary
      COG5048
      Location:233 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    35. NM_013400.4 → NP_037532.2  replication initiator 1 isoform 1

      See identical proteins and their annotated locations for NP_037532.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 3, 5, 6, and 17-36 all encode the same isoform (1).
      Source sequence(s)
      AL046625, BC000363, CX166683
      Consensus CDS
      CCDS43677.1
      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1
      Related
      ENSP00000380451.2, ENST00000397281.6
      Conserved Domains (2) summary
      COG5048
      Location:233 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      150368096..150374039
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024446737.2 → XP_024302505.1  replication initiator 1 isoform X1

      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1
      Conserved Domains (2) summary
      COG5048
      Location:233 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_024446738.2 → XP_024302506.1  replication initiator 1 isoform X1

      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1
      Conserved Domains (2) summary
      COG5048
      Location:233 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:461 → 481
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_047420279.1 → XP_047276235.1  replication initiator 1 isoform X1

      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1

    4. XM_047420278.1 → XP_047276234.1  replication initiator 1 isoform X1

      UniProtKB/Swiss-Prot
      C9J3L7, D3DWZ1, Q7LE03, Q9BUZ6, Q9BWE0, Q9NZH2, Q9UMP5
      UniProtKB/TrEMBL
      A0A090N8H1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      151546435..151552378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358014.1 → XP_054213989.1  replication initiator 1 isoform X1

    2. XM_054358015.1 → XP_054213990.1  replication initiator 1 isoform X1

    3. XM_054358017.1 → XP_054213992.1  replication initiator 1 isoform X1

    4. XM_054358016.1 → XP_054213991.1  replication initiator 1 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_014374.3: Suppressed sequence

      Description
      NM_014374.3: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BWE0.1 GenPept UniProtKB/Swiss-Prot:Q9BWE0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous