Sorbs2 sorbin and SH3 domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sorbs2provided by MGI
Official Full Name: sorbin and SH3 domain containing 2provided by MGI
Primary source: MGI:MGI:1924574
See related: Ensembl:ENSMUSG00000031626 AllianceGenome:MGI:1924574
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Argbp2; nArgBP2; mKIAA0777; A530071H08; 2010203O03Rik; 9430041O17Rik
Summary: Enables protein domain specific binding activity. Acts upstream of or within Notch signaling pathway; acetylcholine receptor signaling pathway; and regulation of skeletal muscle acetylcholine-gated channel clustering. Located in plasma membrane and synapse. Is expressed in several structures, including alimentary system; brain; cardiovascular system; cranium; and foot bone. Orthologous to human SORBS2 (sorbin and SH3 domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in heart adult (RPKM 23.2), cortex adult (RPKM 14.3) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B1.1; 8 25.44 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (45960470..46280943)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (45507788..45827906)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sorbs2 Deficiency and Vascular BK Channelopathy in Diabetes.
Title: Sorbs2 Deficiency and Vascular BK Channelopathy in Diabetes.
MiR-484 promotes nonalcoholic fatty liver disease progression in mice via downregulation of Sorbs2.
Title: MiR-484 promotes nonalcoholic fatty liver disease progression in mice via downregulation of Sorbs2.
Knockout of Sorbin And SH3 Domain Containing 2 (Sorbs2) in Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice.
Title: Knockout of Sorbin And SH3 Domain Containing 2 (Sorbs2) in Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice.
The interaction protein of SORBS2 in myocardial tissue to find out the pathogenic mechanism of LVNC disease.
Title: The interaction protein of SORBS2 in myocardial tissue to find out the pathogenic mechanism of LVNC disease.
Changes in ion channel expression and function associated with cardiac arrhythmogenic remodeling by Sorbs2.
Title: Changes in ion channel expression and function associated with cardiac arrhythmogenic remodeling by Sorbs2.
Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy.
Title: Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy.
the present study provides strong evidence that miR-21-3p controls sepsis-associated cardiac dysfunction via regulating SORBS2. Inhibition of miR-21-3p might be a protective strategy to treat sepsis-induced cardiac dysfunction.
Title: miR-21-3p controls sepsis-associated cardiac dysfunction via regulating SORBS2.
The nArgBP2 binds to the two most prominent postsynaptic proteins that are associated with various mood disorders, we propose that nArgBP2could function as a hub able to link together etiological factors of different disorders.
Title: nArgBP2 as a hub molecule in the etiology of various neuropsychiatric disorders.
The study screened CrkL binding proteins using RNA interference (RNAi) and identified Sorbs1 and Sorbs2 as two proteins that are enriched at AChR clusters and are required for the formation of AChR aggregation in vitro.
Title: Sorbs1 and -2 Interact with CrkL and Are Required for Acetylcholine Receptor Cluster Formation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8Mit176 (e-PCR), detects polymorphism
- UniSTS:131383

43.MMHAP66FLG4.seq (e-PCR)
- UniSTS:124508

D19217 (e-PCR)
- UniSTS:124793

D8Mit297 (e-PCR), detects polymorphism
- UniSTS:131509

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within acetylcholine receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of skeletal muscle acetylcholine-gated channel clustering	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sorbin and SH3 domain-containing protein 2

Names: Arg/Abl-binding protein 2; Arg/Abl-interacting protein ArgBP2; arg-binding protein 2; arg/Abl-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205219.1 → NP_001192148.1 sorbin and SH3 domain-containing protein 2 isoform 1

See identical proteins and their annotated locations for NP_001192148.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC113469, AC116747, AC116861

Consensus CDS

CCDS57618.1

UniProtKB/Swiss-Prot

Q3USC6, Q3UTJ2, Q80TS1, Q8BJL6, Q8BJU3, Q8BLW9, Q8BX47, Q8CHU0

UniProtKB/TrEMBL

B9EKP8

Related

ENSMUSP00000128000.3, ENSMUST00000171337.10

Conserved Domains (4) summary

smart00459
Location:167 → 217

Sorb; Sorbin homologous domain

cd11917
Location:1154 → 1214

SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11920
Location:980 → 1034

SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11923
Location:1055 → 1111

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
NM_001310707.1 → NP_001297636.1 sorbin and SH3 domain-containing protein 2 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences but maintains the reading frame compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.

Source sequence(s)

AC113469, AK041051, AK050951, AK083429, AK140498, BB609472, BC157944, BE862797, CN535874

Consensus CDS

CCDS80872.1

UniProtKB/TrEMBL

D3Z080

Related

ENSMUSP00000123250.2, ENSMUST00000132139.9

Conserved Domains (3) summary

smart00459
Location:144 → 194

Sorb; Sorbin homologous domain

cd11923
Location:558 → 614

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cl17036
Location:483 → 537

SH3; Src Homology 3 domain superfamily
NM_001310708.1 → NP_001297637.1 sorbin and SH3 domain-containing protein 2 isoform 4

See identical proteins and their annotated locations for NP_001297637.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences but maintains the reading frame compared to variant 1. It encodes isoform 4, which is shorter than isoform 1.

Source sequence(s)

AC113469, AC116747, BC157944, BE862797

Consensus CDS

CCDS80874.1

UniProtKB/TrEMBL

B2RXQ9

Related

ENSMUSP00000121619.2, ENSMUST00000130011.8

Conserved Domains (4) summary

cd11923
Location:493 → 549

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

PHA03307
Location:232 → 374

PHA03307; transcriptional regulator ICP4; Provisional

pfam02208
Location:116 → 157

Sorb; Sorbin homologous domain

cl17036
Location:592 → 652

SH3; Src Homology 3 domain superfamily
NM_001402663.1 → NP_001389592.1 sorbin and SH3 domain-containing protein 2 isoform 5

Status: VALIDATED

Source sequence(s)

AC113469, AC116747, AC158351
NM_001402664.1 → NP_001389593.1 sorbin and SH3 domain-containing protein 2 isoform 6

Status: VALIDATED

Source sequence(s)

AC113469, AC116747
NM_001402665.1 → NP_001389594.1 sorbin and SH3 domain-containing protein 2 isoform 7

Status: VALIDATED

Source sequence(s)

AC113469, AC116747
NM_001402666.1 → NP_001389595.1 sorbin and SH3 domain-containing protein 2 isoform 8

Status: VALIDATED

Source sequence(s)

AC113469, AC116747, AC158351
NM_001402667.1 → NP_001389596.1 sorbin and SH3 domain-containing protein 2 isoform 9

Status: VALIDATED

Source sequence(s)

AC113469, AC116747, AC158351
NM_001402668.1 → NP_001389597.1 sorbin and SH3 domain-containing protein 2 isoform 10

Status: VALIDATED

Source sequence(s)

AC113469, AC116747, AC158351
NM_001402669.1 → NP_001389598.1 sorbin and SH3 domain-containing protein 2 isoform 11

Status: VALIDATED

Source sequence(s)

AC113469, AC116747, AC158351
NM_001402670.1 → NP_001389599.1 sorbin and SH3 domain-containing protein 2 isoform 12

Status: VALIDATED

Source sequence(s)

AC113469, AC116747

UniProtKB/TrEMBL

A0A1L7NR37
NM_001402671.1 → NP_001389600.1 sorbin and SH3 domain-containing protein 2 isoform 13

Status: VALIDATED

Source sequence(s)

AC113469, AC116747, AC158351
NM_001402672.1 → NP_001389601.1 sorbin and SH3 domain-containing protein 2 isoform 14

Status: VALIDATED

Source sequence(s)

AC113469, AC116747, AC116861
NM_001402673.1 → NP_001389602.1 sorbin and SH3 domain-containing protein 2 isoform 15

Status: VALIDATED

Source sequence(s)

AC113469, AC116747, AC158351
NM_001402674.1 → NP_001389603.1 sorbin and SH3 domain-containing protein 2 isoform 16

Status: VALIDATED

Source sequence(s)

AC113469, AC116747, AC158351

UniProtKB/TrEMBL

A0A0R4J1W0
NM_001402675.1 → NP_001389604.1 sorbin and SH3 domain-containing protein 2 isoform 9

Status: VALIDATED

Source sequence(s)

AC113469, AC116747
NM_172752.4 → NP_766340.4 sorbin and SH3 domain-containing protein 2 isoform 2

See identical proteins and their annotated locations for NP_766340.4

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AC113469, AC116747, AC116861

Consensus CDS

CCDS57619.1

UniProtKB/Swiss-Prot

Q3USC6, Q3UTJ2, Q80TS1, Q8BJL6, Q8BJU3, Q8BLW9, Q8BX47, Q8CHU0

UniProtKB/TrEMBL

B7ZWM6, E9Q0B0

Related

ENSMUSP00000067641.8, ENSMUST00000067107.15

Conserved Domains (4) summary

smart00459
Location:167 → 217

Sorb; Sorbin homologous domain

cd11917
Location:1136 → 1196

SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11920
Location:962 → 1016

SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11923
Location:1037 → 1093

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

45960470..46280943

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153896.1 → XP_036009789.1 sorbin and SH3 domain-containing protein 2 isoform X10

UniProtKB/Swiss-Prot

Q3USC6, Q3UTJ2, Q80TS1, Q8BJL6, Q8BJU3, Q8BLW9, Q8BX47, Q8CHU0

Conserved Domains (4) summary

cd11920
Location:995 → 1049

SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11923
Location:1070 → 1126

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

pfam02208
Location:147 → 188

Sorb; Sorbin homologous domain

cl17036
Location:1169 → 1219

SH3; Src Homology 3 domain superfamily
XM_030243439.2 → XP_030099299.1 sorbin and SH3 domain-containing protein 2 isoform X29

Conserved Domains (3) summary

smart00459
Location:167 → 217

Sorb; Sorbin homologous domain

cd11923
Location:582 → 638

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cl17036
Location:681 → 741

SH3; Src Homology 3 domain superfamily
XM_036153910.1 → XP_036009803.1 sorbin and SH3 domain-containing protein 2 isoform X36

Conserved Domains (3) summary

smart00459
Location:167 → 217

Sorb; Sorbin homologous domain

cd11923
Location:509 → 565

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cl17036
Location:608 → 668

SH3; Src Homology 3 domain superfamily
XM_036153905.1 → XP_036009798.1 sorbin and SH3 domain-containing protein 2 isoform X28

Conserved Domains (3) summary

smart00459
Location:144 → 194

Sorb; Sorbin homologous domain

cd11923
Location:586 → 642

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cl17036
Location:685 → 745

SH3; Src Homology 3 domain superfamily
XM_036153909.1 → XP_036009802.1 sorbin and SH3 domain-containing protein 2 isoform X35

Conserved Domains (4) summary

cd11923
Location:524 → 580

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

PHA03307
Location:263 → 405

PHA03307; transcriptional regulator ICP4; Provisional

pfam02208
Location:147 → 188

Sorb; Sorbin homologous domain

cl17036
Location:449 → 503

SH3; Src Homology 3 domain superfamily
XM_036153911.1 → XP_036009804.1 sorbin and SH3 domain-containing protein 2 isoform X38

Conserved Domains (3) summary

smart00459
Location:136 → 186

Sorb; Sorbin homologous domain

cd11923
Location:479 → 535

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cl17036
Location:578 → 638

SH3; Src Homology 3 domain superfamily
XM_017312696.2 → XP_017168185.1 sorbin and SH3 domain-containing protein 2 isoform X41

Conserved Domains (3) summary

smart00459
Location:113 → 163

Sorb; Sorbin homologous domain

cd11923
Location:456 → 512

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cl17036
Location:555 → 615

SH3; Src Homology 3 domain superfamily
XM_006509385.1 → XP_006509448.1 sorbin and SH3 domain-containing protein 2 isoform X39

Related

ENSMUSP00000118353.2, ENSMUST00000153798.8

Conserved Domains (3) summary

smart00459
Location:136 → 186

Sorb; Sorbin homologous domain

cd11923
Location:478 → 534

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cl17036
Location:577 → 637

SH3; Src Homology 3 domain superfamily
XM_036153912.1 → XP_036009805.1 sorbin and SH3 domain-containing protein 2 isoform X40

UniProtKB/TrEMBL

A0A0R4J1W0

Related

ENSMUSP00000121235.2, ENSMUST00000139869.8

Conserved Domains (3) summary

cd11923
Location:464 → 520

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

pfam02208
Location:139 → 180

Sorb; Sorbin homologous domain

cl17036
Location:563 → 623

SH3; Src Homology 3 domain superfamily
XM_011242198.1 → XP_011240500.1 sorbin and SH3 domain-containing protein 2 isoform X1

Conserved Domains (4) summary

smart00459
Location:372 → 422

Sorb; Sorbin homologous domain

cd11917
Location:1441 → 1501

SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11920
Location:1267 → 1321

SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11923
Location:1342 → 1398

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
XM_011242200.1 → XP_011240502.1 sorbin and SH3 domain-containing protein 2 isoform X3

Conserved Domains (4) summary

smart00459
Location:372 → 422

Sorb; Sorbin homologous domain

cd11920
Location:1267 → 1321

SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11923
Location:1342 → 1398

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cl17036
Location:1441 → 1491

SH3; Src Homology 3 domain superfamily
XM_011242199.1 → XP_011240501.1 sorbin and SH3 domain-containing protein 2 isoform X2

Conserved Domains (4) summary

smart00459
Location:372 → 422

Sorb; Sorbin homologous domain

cd11917
Location:1440 → 1500

SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11920
Location:1266 → 1320

SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11923
Location:1341 → 1397

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
XM_011242201.1 → XP_011240503.1 sorbin and SH3 domain-containing protein 2 isoform X4

Conserved Domains (4) summary

smart00459
Location:372 → 422

Sorb; Sorbin homologous domain

cd11920
Location:1266 → 1320

SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11923
Location:1341 → 1397

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cl17036
Location:1440 → 1490

SH3; Src Homology 3 domain superfamily
XM_036153897.1 → XP_036009790.1 sorbin and SH3 domain-containing protein 2 isoform X11

Conserved Domains (4) summary

smart00459
Location:372 → 422

Sorb; Sorbin homologous domain

cd11920
Location:740 → 794

SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11923
Location:815 → 871

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cl17036
Location:914 → 974

SH3; Src Homology 3 domain superfamily
XM_011242205.1 → XP_011240507.1 sorbin and SH3 domain-containing protein 2 isoform X12

Conserved Domains (3) summary

smart00459
Location:372 → 422

Sorb; Sorbin homologous domain

cd11923
Location:814 → 870

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cl17036
Location:913 → 973

SH3; Src Homology 3 domain superfamily
XM_030243433.1 → XP_030099293.1 sorbin and SH3 domain-containing protein 2 isoform X13

Conserved Domains (3) summary

smart00459
Location:372 → 422

Sorb; Sorbin homologous domain

cd11923
Location:814 → 870

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cl17036
Location:739 → 793

SH3; Src Homology 3 domain superfamily
XM_011242206.1 → XP_011240508.1 sorbin and SH3 domain-containing protein 2 isoform X15

Conserved Domains (4) summary

smart00459
Location:372 → 422

Sorb; Sorbin homologous domain

cd11923
Location:786 → 842

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

PHA03307
Location:543 → 706

PHA03307; transcriptional regulator ICP4; Provisional

cl17036
Location:885 → 945

SH3; Src Homology 3 domain superfamily
XM_030243435.1 → XP_030099295.1 sorbin and SH3 domain-containing protein 2 isoform X16

Conserved Domains (4) summary

smart00459
Location:372 → 422

Sorb; Sorbin homologous domain

cd11923
Location:786 → 842

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

PHA03307
Location:543 → 706

PHA03307; transcriptional regulator ICP4; Provisional

cl17036
Location:711 → 765

SH3; Src Homology 3 domain superfamily
XM_017312691.1 → XP_017168180.1 sorbin and SH3 domain-containing protein 2 isoform X17

Conserved Domains (5) summary

smart00459
Location:372 → 422

Sorb; Sorbin homologous domain

cd11920
Location:692 → 746

SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11923
Location:767 → 823

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

PHA03307
Location:506 → 648

PHA03307; transcriptional regulator ICP4; Provisional

cl17036
Location:866 → 916

SH3; Src Homology 3 domain superfamily
XM_011242202.1 → XP_011240504.1 sorbin and SH3 domain-containing protein 2 isoform X5

UniProtKB/Swiss-Prot

Q3USC6, Q3UTJ2, Q80TS1, Q8BJL6, Q8BJU3, Q8BLW9, Q8BX47, Q8CHU0

Conserved Domains (4) summary

smart00459
Location:372 → 422

Sorb; Sorbin homologous domain

cd11917
Location:1340 → 1400

SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11920
Location:1166 → 1220

SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11923
Location:1241 → 1297

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
XM_030243437.1 → XP_030099297.1 sorbin and SH3 domain-containing protein 2 isoform X22

Conserved Domains (3) summary

smart00459
Location:372 → 422

Sorb; Sorbin homologous domain

cd11923
Location:715 → 771

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cl17036
Location:814 → 874

SH3; Src Homology 3 domain superfamily
XM_030243438.1 → XP_030099298.1 sorbin and SH3 domain-containing protein 2 isoform X23

Conserved Domains (3) summary

smart00459
Location:372 → 422

Sorb; Sorbin homologous domain

cd11923
Location:714 → 770

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cl17036
Location:813 → 873

SH3; Src Homology 3 domain superfamily
XM_036153903.1 → XP_036009796.1 sorbin and SH3 domain-containing protein 2 isoform X24

Conserved Domains (4) summary

cd11920
Location:625 → 679

SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11923
Location:700 → 756

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

pfam02208
Location:375 → 416

Sorb; Sorbin homologous domain

cl17036
Location:799 → 859

SH3; Src Homology 3 domain superfamily
XM_036153895.1 → XP_036009788.1 sorbin and SH3 domain-containing protein 2 isoform X6

UniProtKB/Swiss-Prot

Q3USC6, Q3UTJ2, Q80TS1, Q8BJL6, Q8BJU3, Q8BLW9, Q8BX47, Q8CHU0

Conserved Domains (4) summary

smart00459
Location:167 → 217

Sorb; Sorbin homologous domain

cd11917
Location:1207 → 1267

SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11920
Location:1033 → 1087

SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11923
Location:1108 → 1164

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
XM_011242207.1 → XP_011240509.1 sorbin and SH3 domain-containing protein 2 isoform X25

Conserved Domains (4) summary

smart00459
Location:167 → 217

Sorb; Sorbin homologous domain

cd11923
Location:581 → 637

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

PHA03307
Location:345 → 507

PHA03307; transcriptional regulator ICP4; Provisional

cl17036
Location:680 → 740

SH3; Src Homology 3 domain superfamily
XM_011242204.1 → XP_011240506.1 sorbin and SH3 domain-containing protein 2 isoform X8

UniProtKB/Swiss-Prot

Q3USC6, Q3UTJ2, Q80TS1, Q8BJL6, Q8BJU3, Q8BLW9, Q8BX47, Q8CHU0

Conserved Domains (4) summary

smart00459
Location:167 → 217

Sorb; Sorbin homologous domain

cd11917
Location:1135 → 1195

SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11920
Location:961 → 1015

SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11923
Location:1036 → 1092

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
XM_017312692.1 → XP_017168181.1 sorbin and SH3 domain-containing protein 2 isoform X27

Conserved Domains (4) summary

smart00459
Location:167 → 212

Sorb; Sorbin homologous domain

cd11923
Location:547 → 603

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

PHA03307
Location:286 → 428

PHA03307; transcriptional regulator ICP4; Provisional

cl17036
Location:646 → 706

SH3; Src Homology 3 domain superfamily
XM_017312687.1 → XP_017168176.1 sorbin and SH3 domain-containing protein 2 isoform X7

UniProtKB/Swiss-Prot

Q3USC6, Q3UTJ2, Q80TS1, Q8BJL6, Q8BJU3, Q8BLW9, Q8BX47, Q8CHU0

UniProtKB/TrEMBL

A0A0S3CWK3

Related

ENSMUSP00000070720.8, ENSMUST00000067065.14

Conserved Domains (4) summary

smart00459
Location:144 → 189

Sorb; Sorbin homologous domain

cd11917
Location:1197 → 1257

SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11920
Location:1023 → 1077

SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11923
Location:1098 → 1154

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
XM_011242209.1 → XP_011240511.1 sorbin and SH3 domain-containing protein 2 isoform X31

Conserved Domains (4) summary

smart00459
Location:144 → 189

Sorb; Sorbin homologous domain

cd11923
Location:524 → 580

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

PHA03307
Location:263 → 405

PHA03307; transcriptional regulator ICP4; Provisional

cl17036
Location:623 → 683

SH3; Src Homology 3 domain superfamily
XM_030243443.1 → XP_030099303.1 sorbin and SH3 domain-containing protein 2 isoform X43

Conserved Domains (3) summary

cd11923
Location:329 → 385

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cl02617
Location:4 → 36

Sorb; Sorbin homologous domain

cl17036
Location:254 → 308

SH3; Src Homology 3 domain superfamily
XM_006509387.1 → XP_006509450.1 sorbin and SH3 domain-containing protein 2 isoform X42

Conserved Domains (3) summary

cd11923
Location:328 → 384

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cl02617
Location:4 → 36

Sorb; Sorbin homologous domain

cl17036
Location:427 → 487

SH3; Src Homology 3 domain superfamily
XM_030243444.1 → XP_030099304.1 sorbin and SH3 domain-containing protein 2 isoform X44

Conserved Domains (3) summary

cd11923
Location:328 → 384

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cl02617
Location:4 → 36

Sorb; Sorbin homologous domain

cl17036
Location:253 → 307

SH3; Src Homology 3 domain superfamily
XM_006509375.1 → XP_006509438.1 sorbin and SH3 domain-containing protein 2 isoform X14

UniProtKB/TrEMBL

Z4YJR7

Conserved Domains (4) summary

cd11917
Location:939 → 999

SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cd11923
Location:840 → 896

SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

cl02617
Location:4 → 31

Sorb; Sorbin homologous domain

cl17036
Location:765 → 819

SH3; Src Homology 3 domain superfamily