RARRES1 retinoic acid receptor responder 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RARRES1provided by HGNC
Official Full Name: retinoic acid receptor responder 1provided by HGNC
Primary source: HGNC:HGNC:9867
See related: Ensembl:ENSG00000118849 MIM:605090; AllianceGenome:HGNC:9867
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LXNL; TIG1; PERG-1
Summary: This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Expression: Broad expression in appendix (RPKM 33.7), urinary bladder (RPKM 25.5) and 17 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q25.32

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (158696892..158732457, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (161470815..161506388, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (158414681..158450246, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion.
Title: GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion.
TIG1 Inhibits the mTOR Signaling Pathway in Malignant Melanoma Through the VAC14 Protein.
Title: TIG1 Inhibits the mTOR Signaling Pathway in Malignant Melanoma Through the VAC14 Protein.
Interaction of RARRES1 with ICAM1 modulates macrophages to suppress the progression of kidney renal clear cell carcinoma.
Title: Interaction of RARRES1 with ICAM1 modulates macrophages to suppress the progression of kidney renal clear cell carcinoma.
Involvement of miR-769-5p/Retinoic Acid Receptor Responder 1 Axis in the Progression of Osteosarcoma: Characterization of Potential Therapeutic Targets.
Title: Involvement of miR-769-5p/Retinoic Acid Receptor Responder 1 Axis in the Progression of Osteosarcoma: Characterization of Potential Therapeutic Targets.
Tazarotene-induced gene 1 interacts with Polo-like kinase 2 and inhibits cell proliferation in HCT116 colorectal cancer cells.
Title: Tazarotene-induced gene 1 interacts with Polo-like kinase 2 and inhibits cell proliferation in HCT116 colorectal cancer cells.
Autocrine and paracrine effects of a novel podocyte gene, RARRES1.
Title: Autocrine and paracrine effects of a novel podocyte gene, RARRES1.
Cathepsin V Mediates the Tazarotene-induced Gene 1-induced Reduction in Invasion in Colorectal Cancer Cells.
Title: Cathepsin V Mediates the Tazarotene-induced Gene 1-induced Reduction in Invasion in Colorectal Cancer Cells.
Expression of RARRES1 and AGBL2 and progression of conventional renal cell carcinoma.
Title: Expression of RARRES1 and AGBL2 and progression of conventional renal cell carcinoma.
Soluble RARRES1 induces podocyte apoptosis to promote glomerular disease progression.
Title: Soluble RARRES1 induces podocyte apoptosis to promote glomerular disease progression.
Investigated whether tazarotene-induced gene 1 protein (TIG1) affects the activity of urokinase plasminogen-type activator, which is negatively regulated by serine peptidase inhibitor Kazal type 2 (SPINK2), potentially preventing epithelial mesenchymal transition and suppressing cell migration and invasion.
Title: Tazarotene-Induced Gene 1 (TIG1) Interacts with Serine Protease Inhibitor Kazal-Type 2 (SPINK2) to Inhibit Cellular Invasion of Testicular Carcinoma Cells.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH102271 (e-PCR)
- UniSTS:96605

SHGC-77489 (e-PCR)
- UniSTS:70257

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables metalloendopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular exosome	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: retinoic acid receptor responder protein 1

Names: RAR-responsive protein TIG1; latexin-like; phorbol ester-induced gene 1 protein; retinoic acid receptor responder (tazarotene induced) 1; tazarotene-induced gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002888.4 → NP_002879.2 retinoic acid receptor responder protein 1 isoform 2 precursor

See identical proteins and their annotated locations for NP_002879.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 3' end-region compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, as compared to isoform 1.

Source sequence(s)

AC080013, BC029640, BM919188

Consensus CDS

CCDS54665.1

UniProtKB/Swiss-Prot

P49788

Related

ENSP00000418556.1, ENST00000479756.1

Conserved Domains (1) summary

pfam06907
Location:52 → 227

Latexin; Latexin
NM_206963.2 → NP_996846.1 retinoic acid receptor responder protein 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_996846.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. It encodes the longer isoform (1).

Source sequence(s)

AC080013, AK130079, BC029640, BM919188

Consensus CDS

CCDS3184.1

UniProtKB/Swiss-Prot

P49788, Q8N1D7

Related

ENSP00000237696.5, ENST00000237696.10

Conserved Domains (1) summary

pfam06907
Location:52 → 274

Latexin; Latexin