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    AKR2 putative palmitoyltransferase AKR2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854199, updated on 17-May-2024

    Summary

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    Gene symbol
    AKR2
    Gene description
    putative palmitoyltransferase AKR2
    Primary source
    FungiDB:YOR034C
    Locus tag
    YOR034C
    See related
    SGD:S000005560; AllianceGenome:SGD:S000005560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable palmitoyltransferase activity. Predicted to be involved in protein palmitoylation. Located in Golgi apparatus. Orthologous to several human genes including ZDHHC17 (zinc finger DHHC-type palmitoyltransferase 17). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (394837..397086, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rad2 family nuclease EXO1 Neighboring gene uncharacterized protein Neighboring gene She4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Long-chain base kinase Lcb4 Is anchored to the membrane through its palmitoylation by Akr1. Kihara A, et al. Mol Cell Biol, 2005 Nov. PMID 16227572, Free PMC Article
    2. The ankyrin repeat-containing protein Akr1p is required for the endocytosis of yeast pheromone receptors. Givan SA, et al. Mol Biol Cell, 1997 Jul. PMID 9243510, Free PMC Article
    3. Analysis of DHHC acyltransferases implies overlapping substrate specificity and a two-step reaction mechanism. Hou H, et al. Traffic, 2009 Aug. PMID 19453970
    4. Swf1-dependent palmitoylation of the SNARE Tlg1 prevents its ubiquitination and degradation. Valdez-Taubas J, et al. EMBO J, 2005 Jul 20. PMID 15973437, Free PMC Article
    5. Global analysis of protein palmitoylation in yeast. Roth AF, et al. Cell, 2006 Jun 2. PMID 16751107, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein-cysteine S-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein palmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein palmitoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative palmitoyltransferase AKR2
    NP_014677.1
    • Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      394837..397086 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183453.1 → NP_014677.1  TPA: putative palmitoyltransferase AKR2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014677.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2A0, Q12013
      UniProtKB/TrEMBL
      A0A8H4BWY9, G2WMR5, N1NY86
      Conserved Domains (4) summary
      COG0666
      Location:1 → 195
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      COG5273
      Location:340 → 711
      COG5273; Uncharacterized protein containing DHHC-type Zn finger [General function prediction only]
      sd00045
      Location:54 → 81
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:190 → 243
      Ank_4; Ankyrin repeats (many copies)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12013.1

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