Mtnr1b melatonin receptor 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mtnr1bprovided by MGI
Official Full Name: melatonin receptor 1Bprovided by MGI
Primary source: MGI:MGI:2181726
See related: Ensembl:ENSMUSG00000050901 AllianceGenome:MGI:2181726
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mt2; Mel1b; Mel-1B-R
Summary: Predicted to enable melatonin receptor activity. Predicted to be involved in several processes, including negative regulation of cGMP-mediated signaling; negative regulation of transport; and regulation of transmission of nerve impulse. Predicted to act upstream of or within circadian rhythm. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in central nervous system; eye; gut; and reproductive system. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MTNR1B (melatonin receptor 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 9 A2; 9 5.15 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (15773910..15785852, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (15862614..15874556, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Melatonin Alleviates Lipopolysaccharide-Induced Abnormal Pregnancy through MTNR1B Regulation of m6A.
Title: Melatonin Alleviates Lipopolysaccharide-Induced Abnormal Pregnancy through MTNR1B Regulation of m6A.
Astrocyte-Ablation of Mtnr1b Increases Anxiety-Like Behavior in Adult Male Mice.
Title: Astrocyte-Ablation of Mtnr1b Increases Anxiety-Like Behavior in Adult Male Mice.
The Uterine Melatonergic Systems of AANAT and Melatonin Membrane Receptor 2 (MT2) Are Essential for Endometrial Receptivity and Early Implantation in Mice.
Title: The Uterine Melatonergic Systems of AANAT and Melatonin Membrane Receptor 2 (MT2) Are Essential for Endometrial Receptivity and Early Implantation in Mice.
Melatonin Type 2 Receptor Activation Regulates Blue Light Exposure-Induced Mouse Corneal Epithelial Damage by Modulating Impaired Autophagy and Apoptosis.
Title: Melatonin Type 2 Receptor Activation Regulates Blue Light Exposure-Induced Mouse Corneal Epithelial Damage by Modulating Impaired Autophagy and Apoptosis.
Mice lacking melatonin MT2 receptors exhibit attentional deficits, anxiety and enhanced social interaction.
Title: Mice lacking melatonin MT2 receptors exhibit attentional deficits, anxiety and enhanced social interaction.
Dysfunction of serotonergic activity and emotional responses across the light-dark cycle in mice lacking melatonin MT2 receptors.
Title: Dysfunction of serotonergic activity and emotional responses across the light-dark cycle in mice lacking melatonin MT(2) receptors.
Melatonin recovers sleep phase delayed by MK-801 through the melatonin MT2 receptor- Ca(2+) -CaMKII-CREB pathway in the ventrolateral preoptic nucleus.
Title: Melatonin recovers sleep phase delayed by MK-801 through the melatonin MT(2) receptor- Ca(2+) -CaMKII-CREB pathway in the ventrolateral preoptic nucleus.
Nociceptive responses in melatonin MT2 receptor knockout mice compared to MT1 and double MT1 /MT2 receptor knockout mice.
Title: Nociceptive responses in melatonin MT(2) receptor knockout mice compared to MT(1) and double MT(1) /MT(2) receptor knockout mice.
Changes in melatonin receptor expression in a murine model of glaucoma.
Title: Changes in melatonin receptor expression in a murine model of glaucoma.
Pharmacological evidence for transactivation within melatonin MT2 and serotonin 5-HT2C receptor heteromers in mouse brain.
Title: Pharmacological evidence for transactivation within melatonin MT(2) and serotonin 5-HT(2C) receptor heteromers in mouse brain.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (4) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:489300

PMC140714P1 (e-PCR)
- UniSTS:270972

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables melatonin receptor activity	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISA Inferred from Sequence Alignment more info	PubMed
acts_upstream_of_or_within circadian rhythm	TAS Traceable Author Statement more info	PubMed
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transmission of nerve impulse	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transmission of nerve impulse	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuronal action potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISA Inferred from Sequence Alignment more info	PubMed

General protein information

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Preferred Names: melatonin receptor type 1B

Names: MT2 melatonin receptor; Mel-1b melatonin receptor; mel1b receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145712.2 → NP_663758.2 melatonin receptor type 1B

See identical proteins and their annotated locations for NP_663758.2

Status: VALIDATED

Source sequence(s)

AB377276

Consensus CDS

CCDS22841.1

UniProtKB/Swiss-Prot

Q80T38, Q8CIQ6, Q8K3K0

UniProtKB/TrEMBL

Q3SXF8

Related

ENSMUSP00000053086.6, ENSMUST00000057920.7

Conserved Domains (2) summary

pfam00001
Location:57 → 308

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:55 → 192

7tm_4; Olfactory receptor