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    ZCWPW2 zinc finger CW-type and PWWP domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 152098, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZCWPW2provided by HGNC
    Official Full Name
    zinc finger CW-type and PWWP domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:23574
    See related
    Ensembl:ENSG00000206559 AllianceGenome:HGNC:23574
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZCW2
    Summary
    Enables methylated histone binding activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 1.3), fat (RPKM 0.5) and 25 other tissues See more
    Orthologs
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    Genomic context

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    Location:
    3p24.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (28348721..28526358)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (28350777..28528247)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (28390212..28567849)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377008 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19620 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:28240525-28241724 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14156 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:28390429-28391409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19621 Neighboring gene C-X9-C motif containing 1 Neighboring gene 5-azacytidine induced 2 Neighboring gene CIAO2A pseudogene 1 Neighboring gene ribosomal protein L34 pseudogene 11 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:28546269-28547201 Neighboring gene protein transport protein SEC31-like Neighboring gene long intergenic non-protein coding RNA 693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14157 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:28798150-28799349 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:28992829-28994028 Neighboring gene uncharacterized LOC105377009

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of a human monoclonal antibody to B antigen in ABO blood type. Kaneko M, et al. Immunol Lett, 2003 Mar 3. PMID 12600744
    2. PRDM9 losses in vertebrates are coupled to those of paralogs ZCWPW1 and ZCWPW2. Cavassim MIA, et al. Proc Natl Acad Sci U S A, 2022 Mar 1. PMID 35217607, Free PMC Article
    3. Family-wide Characterization of Histone Binding Abilities of Human CW Domain-containing Proteins. Liu Y, et al. J Biol Chem, 2016 Apr 22. PMID 26933034, Free PMC Article
    4. The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants. Perry J, et al. Trends Biochem Sci, 2003 Nov. PMID 14607086
    5. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? Nathan JA, et al. EMBO J, 2013 Feb 20. PMID 23314748, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PRDM9 losses in vertebrates are coupled to those of paralogs ZCWPW1 and ZCWPW2.
      Title: PRDM9 losses in vertebrates are coupled to those of paralogs ZCWPW1 and ZCWPW2.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CW-type PWWP domain protein 2
    Names
    zinc finger CW-type and PWWP domain 2
    zinc finger, CW type with PWWP domain 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040432.4 → NP_001035522.1  zinc finger CW-type PWWP domain protein 2 isoform a

      See identical proteins and their annotated locations for NP_001035522.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1). Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC093142, AC098616, BC094696, BU508346, DB306158, DB451817
      Consensus CDS
      CCDS33723.1
      UniProtKB/Swiss-Prot
      Q504Y3
      Related
      ENSP00000373278.2, ENST00000383768.7
      Conserved Domains (2) summary
      pfam07496
      Location:30 → 77
      zf-CW; CW-type Zinc Finger
      cl02554
      Location:97 → 160
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    2. NM_001324169.2 → NP_001311098.1  zinc finger CW-type PWWP domain protein 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2). Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC093142, AC098616
      Consensus CDS
      CCDS33723.1
      UniProtKB/Swiss-Prot
      Q504Y3
      Conserved Domains (2) summary
      pfam07496
      Location:30 → 77
      zf-CW; CW-type Zinc Finger
      cl02554
      Location:97 → 160
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    3. NM_001324170.2 → NP_001311099.1  zinc finger CW-type PWWP domain protein 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3)
      Source sequence(s)
      AC093142, AC098616

    RNA

    1. NR_136708.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4)
      Source sequence(s)
      AC093142, AC098616

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      28348721..28526358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      28350777..28528247
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q504Y3.1 GenPept UniProtKB/Swiss-Prot:Q504Y3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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