Abhd12 abhydrolase domain containing 12, lysophospholipase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abhd12provided by RGD
Official Full Name: abhydrolase domain containing 12, lysophospholipaseprovided by RGD
Primary source: RGD:1562570
See related: Ensembl:ENSRNOG00000036934 AllianceGenome:RGD:1562570
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable acylglycerol lipase activity; lysophospholipase activity; and palmitoyl-(protein) hydrolase activity. Predicted to be involved in glycerolipid catabolic process; protein depalmitoylation; and regulation of inflammatory response. Predicted to act upstream of or within adult walking behavior and response to auditory stimulus. Predicted to be located in dendrite cytoplasm. Predicted to be integral component of membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in PHARC syndrome. Orthologous to human ABHD12 (abhydrolase domain containing 12, lysophospholipase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 371.6), Spleen (RPKM 295.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q41

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (160119724..160179959, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (139659315..139719529, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (146630298..146690375, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

NoName (e-PCR)
- UniSTS:236596

BF414488 (e-PCR)
- UniSTS:248729

AA924737 (e-PCR)
- UniSTS:248248

RH140375 (e-PCR)
- UniSTS:222451

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acylglycerol lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acylglycerol lipase activity	ISO Inferred from Sequence Orthology more info
enables acylglycerol lipase activity	ISS Inferred from Sequence or Structural Similarity more info
enables lysophospholipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysophospholipase activity	ISO Inferred from Sequence Orthology more info
enables lysophospholipase activity	ISS Inferred from Sequence or Structural Similarity more info
enables palmitoyl-(protein) hydrolase activity	ISO Inferred from Sequence Orthology more info
enables phospholipase activity	ISO Inferred from Sequence Orthology more info
enables phospholipase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in acylglycerol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in acylglycerol catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within adult walking behavior	ISO Inferred from Sequence Orthology more info
involved_in glycerophospholipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in macromolecule depalmitoylation	IEA Inferred from Electronic Annotation more info
involved_in monoacylglycerol catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoacylglycerol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in monoacylglycerol catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylserine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphatidylserine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylserine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylserine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipid catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to auditory stimulus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of AMPA glutamate receptor complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: lysophosphatidylserine lipase ABHD12

Names: 2-arachidonoylglycerol hydrolase ABHD12; abhydrolase domain-containing protein 12; monoacylglycerol lipase ABHD12; oxidized phosphatidylserine lipase ABHD12

NP_001019485.1

EC 3.1.1.23

XP_063140457.1

EC 3.1.1.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.