Ppp5c protein phosphatase 5, catalytic subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppp5cprovided by RGD
Official Full Name: protein phosphatase 5, catalytic subunitprovided by RGD
Primary source: RGD:68415
See related: Ensembl:ENSRNOG00000016907 AllianceGenome:RGD:68415
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including G-protein alpha-subunit binding activity; microtubule binding activity; and protein serine/threonine phosphatase activity. Involved in several processes, including histone dephosphorylation; positive regulation of glucocorticoid receptor signaling pathway; and response to arachidonic acid. Located in several cellular components, including cytosol; perikaryon; and proximal dendrite. Orthologous to human PPP5C (protein phosphatase 5 catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 111.8), Kidney (RPKM 110.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (86818297..86842505, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (77690203..77714507, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (78944054..78968361, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased protein phosphatase 5 expression in inflammation-induced left ventricular dysfunction in rats.
Title: Increased protein phosphatase 5 expression in inflammation-induced left ventricular dysfunction in rats.
Relevance of c-Src and protein phosphatase 2A to aromatase activity: Evidence of an acute self-regulating oestrogenic signalling complex in rat central nervous system.
Title: Relevance of c-Src and protein phosphatase 2A to aromatase activity: Evidence of an acute self-regulating oestrogenic signalling complex in rat central nervous system.
The activated Rac1 GTPase translocates PP5 to the plasma membrane and stimulates its activity
Title: Activated Rac1 GTPase translocates protein phosphatase 5 to the cell membrane and stimulates phosphatase activity in vitro.
PP5 is an effector for the Rac GTPase
Title: Rac GTPase signaling through the PP5 protein phosphatase.
PP5 is a negative modulator of HSF1
Title: Protein phosphatase 5 is a negative modulator of heat shock factor 1.
PP5 is a physiological regulator of Raf-1 signalling pathways.
Title: Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5.
Co-localization of PP5 and glucocorticoid receptors in brain regions involved in feedback control of the hypothalamus-pituitary-adrenal axis suggests that PP5 may be an important modulator of glucocorticoid receptor responses in this pathway.
Title: Cellular co-localization of protein phosphatase 5 and glucocorticoid receptors in rat brain.
PP5 plays a pivotal neuroprotective role against cell death induced by Abeta and oxidative stress
Title: Protein phosphatase 5 protects neurons against amyloid-beta toxicity.
Findings are indicative of a regulatory role of PP5 in cardiac function.
Title: Modulation of cardiac contractility by serine/threonine protein phosphatase type 5.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ADP binding	IEA Inferred from Electronic Annotation more info
enables ADP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables G-protein alpha-subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables Hsp90 protein binding	IEA Inferred from Electronic Annotation more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphoprotein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphoprotein phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of glucocorticoid receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to arachidonic acid	IDA Inferred from Direct Assay more info	PubMed
involved_in response to lead ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to lead ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to morphine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to morphine	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein folding chaperone complex	IEA Inferred from Electronic Annotation more info
part_of protein folding chaperone complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in proximal dendrite	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein phosphatase 5

Names: PP5; PPT; protein phosphatase T

NP_113917.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031729.1 → NP_113917.1 serine/threonine-protein phosphatase 5

See identical proteins and their annotated locations for NP_113917.1

Status: PROVISIONAL

Source sequence(s)

X77237

UniProtKB/Swiss-Prot

P53042

UniProtKB/TrEMBL

A6J8F0, Q68G16

Related

ENSRNOP00000023078.3, ENSRNOT00000023078.6

Conserved Domains (3) summary

PLN03088
Location:28 → 139

PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

sd00006
Location:28 → 56

TPR; TPR repeat [structural motif]

cd07417
Location:176 → 491

MPP_PP5_C; PP5, C-terminal metallophosphatase domain