Pdc phosducin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pdcprovided by RGD
Official Full Name: phosducinprovided by RGD
Primary source: RGD:3277
See related: Ensembl:ENSRNOG00000002517 AllianceGenome:RGD:3277
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MEKA; Rpr1; 33DPTP
Summary: Predicted to be involved in regulation of G protein-coupled receptor signaling pathway and visual perception. Predicted to be located in photoreceptor outer segment. Orthologous to human PDC (phosducin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 6.9) and Brain (RPKM 3.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 13q21

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (64847366..64921865)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (62297281..62371754)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (67545430..67558600)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

14-3-3 protein-mediated inhibition of Pdc binding to Gtbetagamma is based on steric occlusion of Pdc's Gtbetagamma binding surface.
Title: Structural Basis for the 14-3-3 Protein-Dependent Inhibition of Phosducin Function.
C-terminal domain of Pdc interacts with the outside surface of the 14-3-3 dimer.
Title: Structural Characterization of Phosducin and Its Complex with the 14-3-3 Protein.
14-3-3 phosphorylation of Pdc at Ser-54 and Ser-73 affects the structure of the whole Pdc molecule.
Title: Structural modulation of phosducin by phosphorylation and 14-3-3 protein binding.
phosducin has a role in regulating signaling in the rod outer segment compartment and there are distinct functions for phosphorylation sites 54 and 71
Title: Compartment-specific phosphorylation of phosducin in rods underlies adaptation to various levels of illumination.
data suggest that phosducin action is based on the reduction of transducin affinity to the membranes of rod outer segments, achieved by keeping the transducin beta gamma subunits apart from the alpha subunit
Title: Phosducin facilitates light-driven transducin translocation in rod photoreceptors. Evidence from the phosducin knockout mouse.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in photoreceptor inner segment	IEA Inferred from Electronic Annotation more info
is_active_in photoreceptor outer segment	IBA Inferred from Biological aspect of Ancestor more info
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosducin

Names: 33 kDa phototransducing protein; PHD; Phototransducing protein, 33 kDa (phosducin); RPR-1; rod photoreceptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012872.2 → NP_037004.2 phosducin

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

Related

ENSRNOP00000003405.3, ENSRNOT00000003405.6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

64847366..64921865

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272041.1 → XP_063128111.1 phosducin isoform X2

UniProtKB/Swiss-Prot

P20942, Q63420

UniProtKB/TrEMBL

A6ICR2
XM_063272042.1 → XP_063128112.1 phosducin isoform X2

UniProtKB/Swiss-Prot

P20942, Q63420

UniProtKB/TrEMBL

A6ICR2
XM_063272043.1 → XP_063128113.1 phosducin isoform X2

UniProtKB/Swiss-Prot

P20942, Q63420

UniProtKB/TrEMBL

A6ICR2
XM_039090380.2 → XP_038946308.1 phosducin isoform X1

Conserved Domains (1) summary

pfam02114
Location:29 → 274

Phosducin
XM_039090382.2 → XP_038946310.1 phosducin isoform X3