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    Adcy2 adenylate cyclase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81636, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Adcy2provided by RGD
    Official Full Name
    adenylate cyclase 2provided by RGD
    Primary source
    RGD:619965
    See related
    Ensembl:ENSRNOG00000032150 AllianceGenome:RGD:619965
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AC2
    Summary
    Enables several functions, including G-protein beta/gamma-subunit complex binding activity; adenylate cyclase binding activity; and metal ion binding activity. Involved in several processes, including cAMP biosynthetic process; cAMP-mediated signaling; and cellular response to forskolin. Located in membrane raft and plasma membrane. Is integral component of plasma membrane. Part of protein-containing complex. Orthologous to human ADCY2 (adenylate cyclase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 209.9), Muscle (RPKM 172.5) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1p11
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (36204054..36650645)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (34375639..34822252)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (37043071..37698390)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 2 subunit beta 1, pseudogene 1 Neighboring gene proteasome 20S subunit alpha 7, pseudogene 1 Neighboring gene transfer RNA proline (anticodon AGG) 24 Neighboring gene proteasome activator complex subunit 2-like Neighboring gene RNA, U6 small nuclear 783 Neighboring gene cilia and flagella associated protein 90 Neighboring gene FAST kinase domains 3 Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase reductase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Muscarinic receptors stimulate AC2 by novel phosphorylation sites, whereas Gβγ subunits exert opposing effects depending on the G-protein source. Shen JX, et al. Biochem J, 2012 Nov 1. PMID 22906005, Free PMC Article
    2. Structure of the adenylyl cyclase catalytic core. Zhang G, et al. Nature, 1997 Mar 20. PMID 9069282
    3. A region of adenylyl cyclase 2 critical for regulation by G protein beta gamma subunits. Chen J, et al. Science, 1995 May 26. PMID 7761832
    4. Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain. Feinstein PG, et al. Proc Natl Acad Sci U S A, 1991 Nov 15. PMID 1719547, Free PMC Article
    5. Stimulation of mammalian G-protein-responsive adenylyl cyclases by carbon dioxide. Townsend PD, et al. J Biol Chem, 2009 Jan 9. PMID 19008230, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AC2 is poised to yield both stimulatory and inhibitory outcomes of receptor activation.
      Title: Muscarinic receptors stimulate AC2 by novel phosphorylation sites, whereas Gβγ subunits exert opposing effects depending on the G-protein source.
    2. AC2 interacts with RXFP1 through AKAP79, whereas the association with PDE4D3 and PKA depends upon beta-arrestin 2 binding to Ser704.
      Title: Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex.
    3. soluble adenylyl cyclase is responsive to both CO(2) and bicarbonate ion
      Title: Stimulation of mammalian G-protein-responsive adenylyl cyclases by carbon dioxide.
    4. Show that adenylyl cyclases 2 and 5 can form a functional heterodimeric complex in HEK293 cells and mouse myocardium.
      Title: Heterodimers of adenylyl cyclases 2 and 5 show enhanced functional responses in the presence of Galpha s.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate cyclase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenylate cyclase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cAMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cAMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cAMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cAMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to forskolin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenylate cyclase type 2
    Names
    ATP pyrophosphate-lyase 2
    adenylate cyclase 2 (brain)
    adenylate cyclase type II
    adenylyl cyclase 2
    NP_112269.2
    XP_038947960.1
    XP_038947965.1
    XP_038947966.1
    XP_038947972.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031007.3 → NP_112269.2  adenylate cyclase type 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P26769
      UniProtKB/TrEMBL
      A6JV23, F1LV12
      Related
      ENSRNOP00000038994.3, ENSRNOT00000047627.4
      Conserved Domains (3) summary
      pfam00211
      Location:882 → 1081
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:37 → 264
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:499 → 603
      DUF1053; Domain of Unknown Function (DUF1053)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      36204054..36650645
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092044.2 → XP_038947972.1  adenylate cyclase type 2 isoform X4

      Conserved Domains (3) summary
      pfam00211
      Location:285 → 469
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:37 → 264
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:499 → 603
      DUF1053; Domain of Unknown Function (DUF1053)

    2. XM_039092038.2 → XP_038947966.1  adenylate cyclase type 2 isoform X3

      Conserved Domains (3) summary
      pfam00211
      Location:285 → 469
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:37 → 264
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:499 → 603
      DUF1053; Domain of Unknown Function (DUF1053)

    3. XM_039092032.2 → XP_038947960.1  adenylate cyclase type 2 isoform X1

      UniProtKB/Swiss-Prot
      P26769
      Conserved Domains (3) summary
      pfam00211
      Location:836 → 1035
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:37 → 264
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:499 → 603
      DUF1053; Domain of Unknown Function (DUF1053)

    4. XM_039092037.2 → XP_038947965.1  adenylate cyclase type 2 isoform X2

      UniProtKB/Swiss-Prot
      P26769
      Conserved Domains (3) summary
      pfam00211
      Location:816 → 1015
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:61 → 198
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:433 → 537
      DUF1053; Domain of Unknown Function (DUF1053)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P26769.1 GenPept UniProtKB/Swiss-Prot:P26769

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