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    Tenm2 teneurin transmembrane protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 23964, updated on 12-May-2024

    Summary

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    Official Symbol
    Tenm2provided by MGI
    Official Full Name
    teneurin transmembrane protein 2provided by MGI
    Primary source
    MGI:MGI:1345184
    See related
    Ensembl:ENSMUSG00000049336 AllianceGenome:MGI:1345184
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Odz2; Odz3; Ten-2; Ten-m2
    Summary
    Enables protein heterodimerization activity and protein homodimerization activity. Predicted to be involved in several processes, including calcium-mediated signaling using intracellular calcium source; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and retrograde trans-synaptic signaling by trans-synaptic protein complex. Predicted to act upstream of or within cell adhesion. Predicted to be located in cell-cell junction; dendritic spine; and postsynaptic membrane. Predicted to be integral component of plasma membrane. Predicted to be active in neuron projection. Is expressed in several structures, including alimentary system; integumental system; nervous system; sensory organ; and skeleton. Orthologous to human TENM2 (teneurin transmembrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E18 (RPKM 3.0), whole brain E14.5 (RPKM 2.9) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tenm2 in Genome Data Viewer
    Location:
    11 A4- A5; 11 21.96 cM
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (35897483..37881486, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (36006656..37237053, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9361 Neighboring gene STARR-positive B cell enhancer ABC_E6965 Neighboring gene STARR-seq mESC enhancer starr_29194 Neighboring gene STARR-seq mESC enhancer starr_29197 Neighboring gene arginyl-tRNA synthetase 1 Neighboring gene WW, C2 and coiled-coil domain containing 1 Neighboring gene predicted gene, 42072 Neighboring gene STARR-seq mESC enhancer starr_29200 Neighboring gene predicted gene 12126 Neighboring gene predicted gene, 42071 Neighboring gene predicted gene, 46251 Neighboring gene predicted gene, 33585 Neighboring gene STARR-seq mESC enhancer starr_29205 Neighboring gene STARR-seq mESC enhancer starr_29206 Neighboring gene predicted gene, 51889 Neighboring gene predicted gene, 22127 Neighboring gene predicted gene, 53696 Neighboring gene predicted gene, 51890 Neighboring gene STARR-seq mESC enhancer starr_29209 Neighboring gene predicted gene, 53695 Neighboring gene STARR-seq mESC enhancer starr_29211 Neighboring gene predicted gene, 33791 Neighboring gene predicted gene 12128 Neighboring gene STARR-seq mESC enhancer starr_29212 Neighboring gene STARR-seq mESC enhancer starr_29213 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene predicted gene 12130

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Teneurins: a novel family of neuronal cell surface proteins in vertebrates, homologous to the Drosophila pair-rule gene product Ten-m. Rubin BP, et al. Dev Biol, 1999 Dec 1. PMID 10588872
    2. Ten-m2 is required for the generation of binocular visual circuits. Young TR, et al. J Neurosci, 2013 Jul 24. PMID 23884953, Free PMC Article
    3. Mouse ten-m/Odz is a new family of dimeric type II transmembrane proteins expressed in many tissues. Oohashi T, et al. J Cell Biol, 1999 May 3. PMID 10225957, Free PMC Article
    4. Genomic response to Wnt signalling is highly context-dependent--evidence from DNA microarray and chromatin immunoprecipitation screens of Wnt/TCF targets. Railo A, et al. Exp Cell Res, 2009 Oct 1. PMID 19563800
    5. The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain. Zhou XH, et al. Gene Expr Patterns, 2003 Aug. PMID 12915301

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • mKIAA1127, D3Bwg1534e, 2610040L17Rik, 9330187F13Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde trans-synaptic signaling by trans-synaptic protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extrinsic component of postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    teneurin-2
    Names
    odd Oz/ten-m homolog 2
    protein Odd Oz/ten-m homolog 2
    tenascin-M2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290702.1 → NP_001277631.1  teneurin-2 isoform 2

      See identical proteins and their annotated locations for NP_001277631.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains reading frame, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AL645912, AL713915, AL713919, AL713956, BX000433, BX539311
      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      UniProtKB/TrEMBL
      B9EJ72
      Conserved Domains (8) summary
      COG3209
      Location:1648 → 2441
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1199 → 1238
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2350 → 2427
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:539 → 561
      EGF_2; EGF-like domain
      cl18310
      Location:1199 → 1529
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:626 → 744
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:10 → 374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2649 → 2726
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

    2. NM_011856.4 → NP_035986.3  teneurin-2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL645912, AL713915, AL713919, AL713956, BX000433, BX539311
      Consensus CDS
      CCDS24546.1
      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      UniProtKB/TrEMBL
      A0A0A0MQB7
      Related
      ENSMUSP00000129951.2, ENSMUST00000163524.8
      Conserved Domains (10) summary
      COG3209
      Location:1679 → 2472
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:671 → 700
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:1230 → 1269
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2381 → 2458
      Rhs_assc_core; RHS repeat-associated core domain
      pfam05593
      Location:1672 → 1710
      RHS_repeat; RHS Repeat
      pfam06484
      Location:10 → 374
      Ten_N; Teneurin Intracellular Region
      pfam07974
      Location:580 → 602
      EGF_2; EGF-like domain
      pfam15636
      Location:2682 → 2757
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:1230 → 1560
      NHL; NHL repeat unit of beta-propeller proteins
      cl19567
      Location:725 → 764
      DSL; Delta serrate ligand

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      35897483..37881486 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156687.1 → XP_036012580.1  teneurin-2 isoform X1

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (7) summary
      COG3209
      Location:1689 → 2482
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1240 → 1279
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2391 → 2468
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:1240 → 1570
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10 → 374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2690 → 2767
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:570 → 885
      exchanger_TraA; outer membrane exchange protein TraA

    2. XM_006533290.4 → XP_006533353.1  teneurin-2 isoform X1

      See identical proteins and their annotated locations for XP_006533353.1

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (7) summary
      COG3209
      Location:1689 → 2482
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1240 → 1279
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2391 → 2468
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:1240 → 1570
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10 → 374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2690 → 2767
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:570 → 885
      exchanger_TraA; outer membrane exchange protein TraA

    3. XM_030245994.1 → XP_030101854.1  teneurin-2 isoform X1

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (7) summary
      COG3209
      Location:1689 → 2482
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1240 → 1279
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2391 → 2468
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:1240 → 1570
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10 → 374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2690 → 2767
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:570 → 885
      exchanger_TraA; outer membrane exchange protein TraA

    4. XM_036156689.1 → XP_036012582.1  teneurin-2 isoform X10

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (7) summary
      COG3209
      Location:1578 → 2371
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1129 → 1168
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2280 → 2357
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:1129 → 1459
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10 → 304
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2579 → 2656
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:459 → 774
      exchanger_TraA; outer membrane exchange protein TraA

    5. XM_036156690.1 → XP_036012583.1  teneurin-2 isoform X11

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (8) summary
      COG3209
      Location:1548 → 2341
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1099 → 1138
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2250 → 2327
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:1099 → 1429
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10 → 304
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2549 → 2626
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033662
      Location:702 → 732
      acid_disulf_rpt; acidic double-disulfide repeat
      NF033759
      Location:500 → 738
      exchanger_TraA; outer membrane exchange protein TraA

    6. XM_006533295.4 → XP_006533358.1  teneurin-2 isoform X7

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (8) summary
      COG3209
      Location:1619 → 2412
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1170 → 1209
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2321 → 2398
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:510 → 532
      EGF_2; EGF-like domain
      cl18310
      Location:1170 → 1500
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:597 → 715
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:10 → 304
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2620 → 2697
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

    7. XM_011249009.3 → XP_011247311.1  teneurin-2 isoform X6

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (8) summary
      COG3209
      Location:1641 → 2434
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1199 → 1227
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2343 → 2420
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:539 → 561
      EGF_2; EGF-like domain
      cl18310
      Location:1199 → 1522
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:626 → 744
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:10 → 374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2642 → 2719
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

    8. XM_006533287.4 → XP_006533350.1  teneurin-2 isoform X1

      See identical proteins and their annotated locations for XP_006533350.1

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (7) summary
      COG3209
      Location:1689 → 2482
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1240 → 1279
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2391 → 2468
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:1240 → 1570
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10 → 374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2690 → 2767
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:570 → 885
      exchanger_TraA; outer membrane exchange protein TraA

    9. XM_006533288.4 → XP_006533351.1  teneurin-2 isoform X1

      See identical proteins and their annotated locations for XP_006533351.1

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (7) summary
      COG3209
      Location:1689 → 2482
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1240 → 1279
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2391 → 2468
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:1240 → 1570
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10 → 374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2690 → 2767
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:570 → 885
      exchanger_TraA; outer membrane exchange protein TraA

    10. XM_030245995.2 → XP_030101855.1  teneurin-2 isoform X9

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (10) summary
      COG3209
      Location:1611 → 2404
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:671 → 700
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:1169 → 1197
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2313 → 2390
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:576 → 602
      EGF_2; EGF-like domain
      cl18310
      Location:1169 → 1492
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:667 → 803
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:10 → 374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2612 → 2689
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      pfam18372
      Location:611 → 628
      I-EGF_1; Integrin beta epidermal growth factor like domain 1

    11. XM_006533296.5 → XP_006533359.1  teneurin-2 isoform X8

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (10) summary
      COG3209
      Location:1618 → 2411
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:671 → 700
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:1169 → 1208
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2320 → 2397
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:576 → 602
      EGF_2; EGF-like domain
      cl18310
      Location:1169 → 1499
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:667 → 803
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:10 → 374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2619 → 2696
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      pfam18372
      Location:611 → 628
      I-EGF_1; Integrin beta epidermal growth factor like domain 1

    12. XM_006533293.5 → XP_006533356.1  teneurin-2 isoform X4

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (9) summary
      COG3209
      Location:1673 → 2466
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:798 → 831
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:1231 → 1259
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2375 → 2452
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:580 → 602
      EGF_2; EGF-like domain
      cl18310
      Location:1231 → 1554
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:667 → 785
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:10 → 374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2674 → 2751
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

    13. XM_006533292.5 → XP_006533355.1  teneurin-2 isoform X3

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      UniProtKB/TrEMBL
      A0A0A0MQ92
      Related
      ENSMUSP00000052014.6, ENSMUST00000057207.6
      Conserved Domains (9) summary
      COG3209
      Location:1680 → 2473
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:798 → 831
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:1231 → 1270
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2382 → 2459
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:580 → 602
      EGF_2; EGF-like domain
      cl18310
      Location:1231 → 1561
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:667 → 785
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:10 → 374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2681 → 2758
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

    14. XM_006533291.5 → XP_006533354.1  teneurin-2 isoform X2

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (8) summary
      COG3209
      Location:1682 → 2475
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1240 → 1268
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2384 → 2461
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:580 → 602
      EGF_2; EGF-like domain
      cl18310
      Location:1240 → 1563
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:667 → 785
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:10 → 374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2683 → 2760
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

    15. XM_006533289.2 → XP_006533352.1  teneurin-2 isoform X1

      See identical proteins and their annotated locations for XP_006533352.1

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (7) summary
      COG3209
      Location:1689 → 2482
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1240 → 1279
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2391 → 2468
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:1240 → 1570
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10 → 374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2690 → 2767
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:570 → 885
      exchanger_TraA; outer membrane exchange protein TraA

    16. XM_036156688.1 → XP_036012581.1  teneurin-2 isoform X1

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (7) summary
      COG3209
      Location:1689 → 2482
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1240 → 1279
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2391 → 2468
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:1240 → 1570
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10 → 374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2690 → 2767
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:570 → 885
      exchanger_TraA; outer membrane exchange protein TraA

    17. XM_036156696.1 → XP_036012589.1  teneurin-2 isoform X21

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (7) summary
      COG3209
      Location:1426 → 2219
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:977 → 1016
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2128 → 2205
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:977 → 1307
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:14 → 152
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2427 → 2504
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:307 → 622
      exchanger_TraA; outer membrane exchange protein TraA

    18. XM_036156698.1 → XP_036012591.1  teneurin-2 isoform X24

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (8) summary
      COG3209
      Location:1396 → 2189
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:947 → 986
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2098 → 2175
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:947 → 1277
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:14 → 152
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2397 → 2474
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033662
      Location:550 → 580
      acid_disulf_rpt; acidic double-disulfide repeat
      NF033759
      Location:348 → 586
      exchanger_TraA; outer membrane exchange protein TraA

    19. XM_006533301.5 → XP_006533364.1  teneurin-2 isoform X19

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (8) summary
      COG3209
      Location:1467 → 2260
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1018 → 1057
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2169 → 2246
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:358 → 380
      EGF_2; EGF-like domain
      cl18310
      Location:1018 → 1348
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:445 → 563
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:10 → 152
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2468 → 2545
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

    20. XM_036156697.1 → XP_036012590.1  teneurin-2 isoform X22

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (8) summary
      COG3209
      Location:1425 → 2218
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:976 → 1015
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2127 → 2204
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:976 → 1306
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10 → 222
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2426 → 2503
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033662
      Location:579 → 609
      acid_disulf_rpt; acidic double-disulfide repeat
      NF033759
      Location:377 → 615
      exchanger_TraA; outer membrane exchange protein TraA

    21. XM_036156694.1 → XP_036012587.1  teneurin-2 isoform X18

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (7) summary
      COG3209
      Location:1487 → 2280
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1038 → 1077
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2189 → 2266
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:1038 → 1368
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10 → 222
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2488 → 2565
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:377 → 683
      exchanger_TraA; outer membrane exchange protein TraA

    22. XM_036156693.1 → XP_036012586.1  teneurin-2 isoform X16

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (7) summary
      COG3209
      Location:1496 → 2289
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1047 → 1086
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2198 → 2275
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:1047 → 1377
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10 → 222
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2497 → 2574
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:377 → 692
      exchanger_TraA; outer membrane exchange protein TraA

    23. XM_036156695.1 → XP_036012588.1  teneurin-2 isoform X20

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (8) summary
      COG3209
      Location:1466 → 2259
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1017 → 1056
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2168 → 2245
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:1017 → 1347
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10 → 222
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2467 → 2544
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033662
      Location:620 → 650
      acid_disulf_rpt; acidic double-disulfide repeat
      NF033759
      Location:418 → 656
      exchanger_TraA; outer membrane exchange protein TraA

    24. XM_036156692.1 → XP_036012585.1  teneurin-2 isoform X14

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (7) summary
      COG3209
      Location:1528 → 2321
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1079 → 1118
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2230 → 2307
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:1079 → 1409
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10 → 222
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2529 → 2606
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:418 → 724
      exchanger_TraA; outer membrane exchange protein TraA

    25. XM_036156691.1 → XP_036012584.1  teneurin-2 isoform X13

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (7) summary
      COG3209
      Location:1530 → 2323
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1088 → 1116
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2232 → 2309
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:1088 → 1411
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:10 → 222
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2531 → 2608
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:418 → 733
      exchanger_TraA; outer membrane exchange protein TraA

    26. XM_006533297.5 → XP_006533360.1  teneurin-2 isoform X12

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (8) summary
      COG3209
      Location:1537 → 2330
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1088 → 1127
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2239 → 2316
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:428 → 450
      EGF_2; EGF-like domain
      cl18310
      Location:1088 → 1418
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:515 → 633
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:10 → 222
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2538 → 2615
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

    27. XM_030245996.2 → XP_030101856.1  teneurin-2 isoform X23

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (10) summary
      COG3209
      Location:1421 → 2214
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:474 → 503
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:972 → 1011
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2123 → 2200
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:379 → 405
      EGF_2; EGF-like domain
      cl18310
      Location:972 → 1302
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:470 → 606
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:1 → 177
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2422 → 2499
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      pfam18372
      Location:414 → 431
      I-EGF_1; Integrin beta epidermal growth factor like domain 1

    28. XM_017314549.2 → XP_017170038.1  teneurin-2 isoform X17

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (8) summary
      COG3209
      Location:1492 → 2285
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1043 → 1082
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2194 → 2271
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:383 → 405
      EGF_2; EGF-like domain
      cl18310
      Location:1043 → 1373
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:470 → 588
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:1 → 177
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2493 → 2570
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

    29. XM_017314548.2 → XP_017170037.1  teneurin-2 isoform X17

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (8) summary
      COG3209
      Location:1492 → 2285
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1043 → 1082
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2194 → 2271
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:383 → 405
      EGF_2; EGF-like domain
      cl18310
      Location:1043 → 1373
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:470 → 588
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:1 → 177
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2493 → 2570
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

    30. XM_006533298.3 → XP_006533361.1  teneurin-2 isoform X15

      See identical proteins and their annotated locations for XP_006533361.1

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      Conserved Domains (8) summary
      COG3209
      Location:1527 → 2320
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1078 → 1117
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2229 → 2306
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:418 → 440
      EGF_2; EGF-like domain
      cl18310
      Location:1078 → 1408
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:505 → 623
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:4 → 212
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2528 → 2605
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

    31. XM_006533294.5 → XP_006533357.1  teneurin-2 isoform X5

      See identical proteins and their annotated locations for XP_006533357.1

      UniProtKB/Swiss-Prot
      Q5NBW7, Q5NBW8, Q80TJ0, Q9JLC0, Q9QYZ1, Q9WTS5
      UniProtKB/TrEMBL
      B9EJ72
      Conserved Domains (8) summary
      COG3209
      Location:1648 → 2441
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1199 → 1238
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:2350 → 2427
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:539 → 561
      EGF_2; EGF-like domain
      cl18310
      Location:1199 → 1529
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01500
      Location:626 → 744
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:10 → 374
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2649 → 2726
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WTS5.1 GenPept UniProtKB/Swiss-Prot:Q9WTS5

    Gene LinkOut

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