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    TTLL10 tubulin tyrosine ligase like 10 [ Homo sapiens (human) ]

    Gene ID: 254173, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TTLL10provided by HGNC
    Official Full Name
    tubulin tyrosine ligase like 10provided by HGNC
    Primary source
    HGNC:HGNC:26693
    See related
    Ensembl:ENSG00000162571 AllianceGenome:HGNC:26693
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TTLL5
    Summary
    Predicted to enable protein-glycine ligase activity, elongating. Predicted to be involved in protein polyglycylation. Predicted to be located in axoneme and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis (RPKM 6.9), lung (RPKM 0.7) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    1p36.33
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1173880..1197936)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (602477..626317)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1109260..1133316)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903818 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1106186-1106753 Neighboring gene microRNA 200a Neighboring gene microRNA 429 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 43 Neighboring gene TTLL10 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1110977-1111495 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1114551-1115050 Neighboring gene MPRA-validated peak5 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 44 Neighboring gene MPRA-validated peak6 silencer Neighboring gene TNF receptor superfamily member 18 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1143552-1144431 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 47 Neighboring gene TNF receptor superfamily member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TTLL10 is a protein polyglycylase that can modify nucleosome assembly protein 1. Ikegami K, et al. FEBS Lett, 2008 Apr 2. PMID 18331838, Free PMC Article
    2. Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. Rogowski K, et al. Cell, 2009 Jun 12. PMID 19524510
    3. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Janke C, et al. Science, 2005 Jun 17. PMID 15890843
    4. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348
    5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ36119, FLJ42131

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT enables protein-glycine ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-glycine ligase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in protein polyglycylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    inactive polyglycylase TTLL10
    Names
    tubulin tyrosine ligase-like family, member 10
    tubulin tyrosine ligase-like family, member 5
    tubulin--tyrosine ligase-like protein 10
    NP_001123517.1
    NP_001358578.1
    NP_694986.2
    XP_005244795.1
    XP_016856395.2
    XP_016856396.2
    XP_016856397.2
    XP_016856398.2
    XP_016856399.2
    XP_016856401.1
    XP_047272797.1
    XP_047272798.1
    XP_047272799.1
    XP_047272826.1
    XP_047272838.1
    XP_054191731.1
    XP_054191732.1
    XP_054191733.1
    XP_054191734.1
    XP_054191735.1
    XP_054191736.1
    XP_054191737.1
    XP_054191738.1
    XP_054191739.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130045.2 → NP_001123517.1  inactive polyglycylase TTLL10 isoform 1

      See identical proteins and their annotated locations for NP_001123517.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Both variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AL162741, AL390719
      Consensus CDS
      CCDS44036.1
      UniProtKB/Swiss-Prot
      B1AMF6, Q5T2W4, Q5T2W5, Q6ZVT0, Q8N9X2
      Related
      ENSP00000368591.1, ENST00000379289.6
      Conserved Domains (3) summary
      PHA03247
      Location:9 → 99
      PHA03247; large tegument protein UL36; Provisional
      PRK07764
      Location:568 → 673
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cl17255
      Location:284 → 548
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    2. NM_001371649.1 → NP_001358578.1  inactive polyglycylase TTLL10 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AL162741, AL390719
      Consensus CDS
      CCDS44036.1
      UniProtKB/Swiss-Prot
      B1AMF6, Q5T2W4, Q5T2W5, Q6ZVT0, Q8N9X2
      Related
      ENSP00000368592.1, ENST00000379290.6
      Conserved Domains (3) summary
      PHA03247
      Location:9 → 99
      PHA03247; large tegument protein UL36; Provisional
      PRK07764
      Location:568 → 673
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cl17255
      Location:284 → 548
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    3. NM_153254.3 → NP_694986.2  inactive polyglycylase TTLL10 isoform 2

      See identical proteins and their annotated locations for NP_694986.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the 5' and 3' termini, compared to variant 3. These differences cause translation initiation from a downstream ATG and an isoform (2) with shorter N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AK093438, AL390719, BC126152, BX117374
      Consensus CDS
      CCDS8.1
      UniProtKB/Swiss-Prot
      Q6ZVT0
      Related
      ENSP00000368590.3, ENST00000379288.3
      Conserved Domains (1) summary
      cl17255
      Location:211 → 373
      ATP-grasp_4; ATP-grasp domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      1173880..1197936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047416841.1 → XP_047272797.1  inactive polyglycylase TTLL10 isoform X1

    2. XM_017000906.2 → XP_016856395.2  inactive polyglycylase TTLL10 isoform X2

    3. XM_047416842.1 → XP_047272798.1  inactive polyglycylase TTLL10 isoform X3

    4. XM_047416843.1 → XP_047272799.1  inactive polyglycylase TTLL10 isoform X1

    5. XM_047416870.1 → XP_047272826.1  inactive polyglycylase TTLL10 isoform X8

      UniProtKB/Swiss-Prot
      B1AMF6, Q5T2W4, Q5T2W5, Q6ZVT0, Q8N9X2

    6. XM_017000909.2 → XP_016856398.2  inactive polyglycylase TTLL10 isoform X6

    7. XM_017000910.3 → XP_016856399.2  inactive polyglycylase TTLL10 isoform X7

    8. XM_017000908.2 → XP_016856397.2  inactive polyglycylase TTLL10 isoform X5

    9. XM_017000907.2 → XP_016856396.2  inactive polyglycylase TTLL10 isoform X4

    10. XM_047416882.1 → XP_047272838.1  inactive polyglycylase TTLL10 isoform X9

    11. XM_017000912.2 → XP_016856401.1  inactive polyglycylase TTLL10 isoform X8

      UniProtKB/Swiss-Prot
      B1AMF6, Q5T2W4, Q5T2W5, Q6ZVT0, Q8N9X2
      Conserved Domains (3) summary
      PHA03247
      Location:9 → 99
      PHA03247; large tegument protein UL36; Provisional
      PRK07764
      Location:568 → 673
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cl17255
      Location:284 → 548
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    12. XM_005244738.2 → XP_005244795.1  inactive polyglycylase TTLL10 isoform X10

      UniProtKB/Swiss-Prot
      Q6ZVT0
      Conserved Domains (1) summary
      cl17255
      Location:211 → 475
      ATP-grasp_4; ATP-grasp domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      602477..626317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335757.1 → XP_054191732.1  inactive polyglycylase TTLL10 isoform X1

    2. XM_054335762.1 → XP_054191737.1  inactive polyglycylase TTLL10 isoform X8

    3. XM_054335756.1 → XP_054191731.1  inactive polyglycylase TTLL10 isoform X11

    4. XM_054335760.1 → XP_054191735.1  inactive polyglycylase TTLL10 isoform X14

    5. XM_054335761.1 → XP_054191736.1  inactive polyglycylase TTLL10 isoform X15

    6. XM_054335759.1 → XP_054191734.1  inactive polyglycylase TTLL10 isoform X13

    7. XM_054335758.1 → XP_054191733.1  inactive polyglycylase TTLL10 isoform X12

    8. XM_054335763.1 → XP_054191738.1  inactive polyglycylase TTLL10 isoform X16

    9. XM_054335764.1 → XP_054191739.1  inactive polyglycylase TTLL10 isoform X10

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZVT0.2 GenPept UniProtKB/Swiss-Prot:Q6ZVT0

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