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    ZDHHC19 zinc finger DHHC-type palmitoyltransferase 19 [ Homo sapiens (human) ]

    Gene ID: 131540, updated on 11-Apr-2024

    Summary

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    Official Symbol
    ZDHHC19provided by HGNC
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 19provided by HGNC
    Primary source
    HGNC:HGNC:20713
    See related
    Ensembl:ENSG00000163958 MIM:618671; AllianceGenome:HGNC:20713
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DHHC19
    Summary
    Enables protein-cysteine S-palmitoyltransferase activity. Involved in peptidyl-L-cysteine S-palmitoylation. Located in Golgi membrane; endoplasmic reticulum; and perinucleolar compartment. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis (RPKM 16.0) See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    3q29
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (196197452..196211400, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (198917010..198930875, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (195924323..195938271, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene transferrin receptor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15051 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195807213-195807712 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15052 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15053 Neighboring gene RNA, U7 small nuclear 18 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr3:195812346-195812518 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:195819312-195819500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21065 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15054 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:195840246-195840363 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15055 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:195853055-195853556 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:195861292-195861451 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195862621-195863421 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21066 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21067 Neighboring gene long intergenic non-protein coding RNA 885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21068 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21069 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21071 Neighboring gene CRISPRi-validated cis-regulatory element chr3.5812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195913396-195914015 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195914016-195914634 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:195917731-195918349 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195919335-195919998 Neighboring gene CRISPRi-validated cis-regulatory element chr3.5817 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21076 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21077 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195924959-195925904 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195929545-195930080 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195930123-195930624 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195930625-195931124 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15057 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15058 Neighboring gene uncharacterized LOC124909479 Neighboring gene uncharacterized LOC105374304 Neighboring gene Sharpr-MPRA regulatory region 7098 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21081 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21082 Neighboring gene solute carrier family 51 member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Zinc finger Asp-His-His-Cys palmitoyl -acyltransferase 19 accelerates tumor progression through wnt/β-catenin pathway and is upregulated by miR-940 in osteosarcoma. Liang S, et al. Bioengineered, 2022 Mar. PMID 35297315, Free PMC Article
    2. Fatty Acid Synthase Promotes the Palmitoylation of Chikungunya Virus nsP1. Zhang N, et al. J Virol, 2019 Feb 1. PMID 30404808, Free PMC Article
    3. Palmitoylation of R-Ras by human DHHC19, a palmitoyl transferase with a CaaX box. Baumgart F, et al. Biochim Biophys Acta, 2010 Mar. PMID 20074548
    4. Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population. Petrovski S, et al. AIDS, 2011 Feb 20. PMID 21160409, Free PMC Article
    5. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. Ohno Y, et al. Biochim Biophys Acta, 2006 Apr. PMID 16647879

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zinc finger Asp-His-His-Cys palmitoyl -acyltransferase 19 accelerates tumor progression through wnt/beta-catenin pathway and is upregulated by miR-940 in osteosarcoma.
      Title: Zinc finger Asp-His-His-Cys palmitoyl -acyltransferase 19 accelerates tumor progression through wnt/β-catenin pathway and is upregulated by miR-940 in osteosarcoma.
    2. The increased palmitoylation of R-Ras cotransfected with DHHC19 is accompanied by an augmented association with membranes as well as with rafts/caveolae.
      Title: Palmitoylation of R-Ras by human DHHC19, a palmitoyl transferase with a CaaX box.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population.
    EBI GWAS Catalog
    Genome-wide association study of hematological and biochemical traits in a Japanese population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC33345

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptidyl-L-cysteine S-palmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-L-cysteine S-palmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of aggrephagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinucleolar compartment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC19
    Names
    DHHC-19
    probable palmitoyltransferase ZDHHC19
    zinc finger DHHC domain-containing protein 19
    zinc finger DHHC-type containing 19
    zinc finger, DHHC domain containing 19
    NP_001034706.1
    XP_006713556.1
    XP_006713557.1
    XP_011510719.1
    XP_054201195.1
    XP_054201196.1
    XP_054201197.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039617.2 → NP_001034706.1  palmitoyltransferase ZDHHC19

      See identical proteins and their annotated locations for NP_001034706.1

      Status: VALIDATED

      Source sequence(s)
      BC022078, BC034801, BG721568, BU929650
      Consensus CDS
      CCDS43190.1
      UniProtKB/Swiss-Prot
      A0A0B4J1W2, A8MSY6, B3KVI1, Q8WVZ1
      Related
      ENSP00000296326.3, ENST00000296326.8
      Conserved Domains (1) summary
      pfam01529
      Location:109 → 181
      DHHC; DHHC palmitoyltransferase

    RNA

    1. NR_135617.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AA724452, AC069257, AK122907, BC022078
      Related
      ENST00000438232.5

    2. NR_135618.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AA724452, BC022078
      Related
      ENST00000397544.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      196197452..196211400 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512417.2 → XP_011510719.1  palmitoyltransferase ZDHHC19 isoform X3

      Conserved Domains (1) summary
      pfam01529
      Location:35 → 107
      DHHC; DHHC palmitoyltransferase

    2. XM_006713494.3 → XP_006713557.1  palmitoyltransferase ZDHHC19 isoform X2

      Conserved Domains (1) summary
      pfam01529
      Location:83 → 155
      DHHC; DHHC palmitoyltransferase

    3. XM_006713493.3 → XP_006713556.1  palmitoyltransferase ZDHHC19 isoform X1

      Conserved Domains (1) summary
      pfam01529
      Location:107 → 179
      DHHC; DHHC palmitoyltransferase

    RNA

    1. XR_007095641.1 RNA Sequence

    2. XR_246038.3 RNA Sequence

    3. XR_007095640.1 RNA Sequence

    4. XR_001740011.2 RNA Sequence

    5. XR_007095638.1 RNA Sequence

    6. XR_001740012.2 RNA Sequence

    7. XR_007095639.1 RNA Sequence

    8. XR_924098.2 RNA Sequence

    9. XR_007095637.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      198917010..198930875 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345222.1 → XP_054201197.1  palmitoyltransferase ZDHHC19 isoform X3

    2. XM_054345221.1 → XP_054201196.1  palmitoyltransferase ZDHHC19 isoform X2

    3. XM_054345220.1 → XP_054201195.1  palmitoyltransferase ZDHHC19 isoform X1

    RNA

    1. XR_008486656.1 RNA Sequence

    2. XR_008486655.1 RNA Sequence

    3. XR_008486654.1 RNA Sequence

    4. XR_008486651.1 RNA Sequence

    5. XR_008486650.1 RNA Sequence

    6. XR_008486653.1 RNA Sequence

    7. XR_008486652.1 RNA Sequence

    8. XR_008486649.1 RNA Sequence

    9. XR_008486648.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WVZ1.2 GenPept UniProtKB/Swiss-Prot:Q8WVZ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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