BRDT bromodomain testis associated [Homo sapiens (human)] - Gene

Summary

Official Symbol: BRDTprovided by HGNC
Official Full Name: bromodomain testis associatedprovided by HGNC
Primary source: HGNC:HGNC:1105
See related: Ensembl:ENSG00000137948 MIM:602144; AllianceGenome:HGNC:1105
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CT9; BRD6; SPGF21
Summary: BRDT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence (a cluster of proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular degradation. The bromodomain is found in proteins that regulate transcription. Several transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Expression: Restricted expression toward testis (RPKM 59.8) See more
Orthologs: mouse all
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Genomic context

Location:: 1p22.1

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (91949371..92014428)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (91794237..91859235)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (92414928..92479985)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bromodomain protein BRDT directs DeltaNp63 function and super-enhancer activity in a subset of esophageal squamous cell carcinomas.
Title: Bromodomain protein BRDT directs ΔNp63 function and super-enhancer activity in a subset of esophageal squamous cell carcinomas.
Discovery and characterization of bromodomain 2-specific inhibitors of BRDT.
Title: Discovery and characterization of bromodomain 2-specific inhibitors of BRDT.
BRDT is a novel regulator of eIF4EBP1 in renal cell carcinoma.
Title: BRDT is a novel regulator of eIF4EBP1 in renal cell carcinoma.
FBP1 modulates the sensitivity of pancreatic cancer cells to BET inhibitors by decreasing the expression of c-Myc. These findings highlight FBP1 could be used as a therapeutic niche for patient-tailored therapies
Title: FBP1 loss contributes to BET inhibitors resistance by undermining c-Myc expression in pancreatic ductal adenocarcinoma.
The bromodomain and extraterminal domain (BET) family consists of BRDT, BRD2, BRD3, and BRD4, each containing 2 bromodomains located N-terminal to extraterminal domain, which is located near C-terminus. Data suggest that 10 distinct acylations participate in binding of BET family proteins to histone 4 (oligopeptide fragments used here); C-terminal bromodomains do not cooperatively bind multiple acylation sites.
Title: Metabolically Derived Lysine Acylations and Neighboring Modifications Tune the Binding of the BET Bromodomains to Histone H4.
The affected patient carries a homozygous bromodomain, testis-specific protein (BRDT) mutation, while the patient's father, mother and elder brother all carry heterozygous BRDT mutations.
Title: Whole-exome sequencing identified a homozygous BRDT mutation in a patient with acephalic spermatozoa.
considered potential associations of 14 single nucleotide polymorphisms (SNPs) in RNF8 and BRDT genes in Chinese patients with non-obstructive azoospermia
Title: Genetic association study of RNF8 and BRDT variants with non-obstructive azoospermia in the Chinese Han population.
assessment of rs3088232 frequency in large group of non-obstructive azoospermia men and fertile controls demonstrated no significant difference between them; conclude that testicular impairments observed were not a consequence of BRDT gene mutation
Title: BRDT gene sequence in human testicular pathologies and the implication of its single nucleotide polymorphism (rs3088232) on fertility.
In human, BRDT is the only BET gene expressed exclusively in testicular germ cells.
Title: Expression of BET genes in testis of men with different spermatogenic impairments.
Suggest that reduced histone methylation in the promoter of BRDT may be associated with increased transcript levels in subfertile patients.
Title: The interaction of modified histones with the bromodomain testis-specific (BRDT) gene and its mRNA level in sperm of fertile donors and subfertile men.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Spermatogenic failure 21 MedGen: C4539991 OMIM: 617644 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of bromodomain, testis-specific (BRDT) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Brdt (e-PCR), detects polymorphism
- UniSTS:528254

AL033575 (e-PCR)
- UniSTS:94180

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables histone binding	IDA Inferred from Direct Assay more info	PubMed
enables histone reader activity	ISS Inferred from Sequence or Structural Similarity more info
enables lysine-acetylated histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coactivator activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in male meiosis I	ISS Inferred from Sequence or Structural Similarity more info
involved_in male meiotic nuclear division	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_positive_effect positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of RNA splicing	ISS Inferred from Sequence or Structural Similarity more info
involved_in sperm DNA condensation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: bromodomain testis-specific protein

Names: RING3-like protein; bromodomain, testis-specific; cancer/testis antigen 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001242805.2 → NP_001229734.2 bromodomain testis-specific protein isoform b

See identical proteins and their annotated locations for NP_001229734.2

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 4. The resulting isoform (b) lacks a short internal segment compared to isoform a. Variants 1, 2, and 3 all encode the same isoform (b).

Source sequence(s)

AC114486, AK302758, AK303008, AY338951, BX648135

Consensus CDS

CCDS735.1

UniProtKB/Swiss-Prot

A6NF68, B7Z811, B7Z890, B7ZAX7, D3DT32, O14789, Q05DQ4, Q58F21, Q6P5T1, Q7Z4A6, Q8IWI6

Related

ENSP00000354568.3, ENST00000362005.7

Conserved Domains (4) summary

cd05497
Location:27 → 133

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:272 → 373

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:509 → 571

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:905 → 947

BRD4_CDT; C-terminal domain of bromodomain protein 4
NM_001242806.2 → NP_001229735.2 bromodomain testis-specific protein isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (4) encodes the longest isoform (a).

Source sequence(s)

AC114486, AK302758, AK303008, AY338951, BX648135, DB072781

UniProtKB/Swiss-Prot

Q58F21

Conserved Domains (4) summary

cd05497
Location:27 → 133

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:276 → 377

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:513 → 575

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:909 → 951

BRD4_CDT; C-terminal domain of bromodomain protein 4
NM_001242807.2 → NP_001229736.2 bromodomain testis-specific protein isoform c

See identical proteins and their annotated locations for NP_001229736.2

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, lacks an alternate in-frame exon, and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 4. The resulting isoform (c) lacks two internal segments compared to isoform a. Variants 5 and 6 both encode the same protein.

Source sequence(s)

AK302758, AK316442, AY338951, BX648135, DC402057

Consensus CDS

CCDS55615.1

UniProtKB/Swiss-Prot

Q58F21

Conserved Domains (4) summary

cd05498
Location:226 → 327

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:463 → 525

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:859 → 901

BRD4_CDT; C-terminal domain of bromodomain protein 4

cl02556
Location:27 → 87

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
NM_001242808.2 → NP_001229737.2 bromodomain testis-specific protein isoform c

See identical proteins and their annotated locations for NP_001229737.2

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks an alternate in-frame exon and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 4. The resulting isoform (c) lacks two internal segments compared to isoform a. Variants 5 and 6 both encode the same protein.

Source sequence(s)

AC114486, AK302758, AY338951, BX648135

Consensus CDS

CCDS55615.1

UniProtKB/Swiss-Prot

Q58F21

Related

ENSP00000378038.3, ENST00000394530.7

Conserved Domains (4) summary

cd05498
Location:226 → 327

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:463 → 525

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:859 → 901

BRD4_CDT; C-terminal domain of bromodomain protein 4

cl02556
Location:27 → 87

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
NM_001242810.2 → NP_001229739.2 bromodomain testis-specific protein isoform d

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (d) is shorter at the N-terminus and lacks a short internal segment compared to isoform a.

Source sequence(s)

AC114486, AK302758, AY338951, BX648135

Consensus CDS

CCDS55616.1

UniProtKB/Swiss-Prot

Q58F21

Related

ENSP00000359416.2, ENST00000370389.6

Conserved Domains (4) summary

cd05498
Location:199 → 300

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:436 → 498

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:832 → 874

BRD4_CDT; C-terminal domain of bromodomain protein 4

cl02556
Location:1 → 60

Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
NM_001726.4 → NP_001717.3 bromodomain testis-specific protein isoform b

See identical proteins and their annotated locations for NP_001717.3

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 4. The resulting isoform (b) lacks a short internal segment compared to isoform a. Variants 1, 2, and 3 all encode the same isoform (b).

Source sequence(s)

AK302758, AY338951, BC047900, BX648135, DC401352

Consensus CDS

CCDS735.1

UniProtKB/Swiss-Prot

A6NF68, B7Z811, B7Z890, B7ZAX7, D3DT32, O14789, Q05DQ4, Q58F21, Q6P5T1, Q7Z4A6, Q8IWI6

Related

ENSP00000384051.1, ENST00000402388.1

Conserved Domains (4) summary

cd05497
Location:27 → 133

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:272 → 373

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:509 → 571

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:905 → 947

BRD4_CDT; C-terminal domain of bromodomain protein 4
NM_207189.4 → NP_997072.2 bromodomain testis-specific protein isoform b

See identical proteins and their annotated locations for NP_997072.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) differs in the 5' UTR and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 4. The resulting isoform (b) lacks a short internal segment compared to isoform a. Variants 1, 2, and 3 all encode the same isoform (b).

Source sequence(s)

AC114486

Consensus CDS

CCDS735.1

UniProtKB/Swiss-Prot

A6NF68, B7Z811, B7Z890, B7ZAX7, D3DT32, O14789, Q05DQ4, Q58F21, Q6P5T1, Q7Z4A6, Q8IWI6

Related

ENSP00000387822.3, ENST00000399546.7

Conserved Domains (4) summary

cd05497
Location:27 → 133

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:272 → 373

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:509 → 571

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:905 → 947

BRD4_CDT; C-terminal domain of bromodomain protein 4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

91949371..92014428

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006710855.5 → XP_006710918.1 bromodomain testis-specific protein isoform X1

See identical proteins and their annotated locations for XP_006710918.1

UniProtKB/Swiss-Prot

A6NF68, B7Z811, B7Z890, B7ZAX7, D3DT32, O14789, Q05DQ4, Q58F21, Q6P5T1, Q7Z4A6, Q8IWI6

Conserved Domains (4) summary

cd05497
Location:27 → 133

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:272 → 373

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:509 → 571

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:905 → 947

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_011542032.4 → XP_011540334.1 bromodomain testis-specific protein isoform X1

See identical proteins and their annotated locations for XP_011540334.1

UniProtKB/Swiss-Prot

A6NF68, B7Z811, B7Z890, B7ZAX7, D3DT32, O14789, Q05DQ4, Q58F21, Q6P5T1, Q7Z4A6, Q8IWI6

Conserved Domains (4) summary

cd05497
Location:27 → 133

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:272 → 373

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:509 → 571

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:905 → 947

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_011542034.4 → XP_011540336.1 bromodomain testis-specific protein isoform X1

See identical proteins and their annotated locations for XP_011540336.1

UniProtKB/Swiss-Prot

A6NF68, B7Z811, B7Z890, B7ZAX7, D3DT32, O14789, Q05DQ4, Q58F21, Q6P5T1, Q7Z4A6, Q8IWI6

Conserved Domains (4) summary

cd05497
Location:27 → 133

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:272 → 373

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:509 → 571

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:905 → 947

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_047428949.1 → XP_047284905.1 bromodomain testis-specific protein isoform X1

UniProtKB/Swiss-Prot

A6NF68, B7Z811, B7Z890, B7ZAX7, D3DT32, O14789, Q05DQ4, Q58F21, Q6P5T1, Q7Z4A6, Q8IWI6
XM_006710856.5 → XP_006710919.1 bromodomain testis-specific protein isoform X1

See identical proteins and their annotated locations for XP_006710919.1

UniProtKB/Swiss-Prot

A6NF68, B7Z811, B7Z890, B7ZAX7, D3DT32, O14789, Q05DQ4, Q58F21, Q6P5T1, Q7Z4A6, Q8IWI6

Conserved Domains (4) summary

cd05497
Location:27 → 133

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:272 → 373

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:509 → 571

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:905 → 947

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_011542035.4 → XP_011540337.1 bromodomain testis-specific protein isoform X1

See identical proteins and their annotated locations for XP_011540337.1

UniProtKB/Swiss-Prot

A6NF68, B7Z811, B7Z890, B7ZAX7, D3DT32, O14789, Q05DQ4, Q58F21, Q6P5T1, Q7Z4A6, Q8IWI6

Conserved Domains (4) summary

cd05497
Location:27 → 133

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:272 → 373

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:509 → 571

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:905 → 947

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_047428955.1 → XP_047284911.1 bromodomain testis-specific protein isoform X1

UniProtKB/Swiss-Prot

A6NF68, B7Z811, B7Z890, B7ZAX7, D3DT32, O14789, Q05DQ4, Q58F21, Q6P5T1, Q7Z4A6, Q8IWI6
XM_047428967.1 → XP_047284923.1 bromodomain testis-specific protein isoform X1

UniProtKB/Swiss-Prot

A6NF68, B7Z811, B7Z890, B7ZAX7, D3DT32, O14789, Q05DQ4, Q58F21, Q6P5T1, Q7Z4A6, Q8IWI6
XM_011542036.4 → XP_011540338.1 bromodomain testis-specific protein isoform X1

See identical proteins and their annotated locations for XP_011540338.1

UniProtKB/Swiss-Prot

A6NF68, B7Z811, B7Z890, B7ZAX7, D3DT32, O14789, Q05DQ4, Q58F21, Q6P5T1, Q7Z4A6, Q8IWI6

Conserved Domains (4) summary

cd05497
Location:27 → 133

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:272 → 373

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:509 → 571

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:905 → 947

BRD4_CDT; C-terminal domain of bromodomain protein 4