Cand1 cullin associated and neddylation disassociated 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cand1provided by MGI
Official Full Name: cullin associated and neddylation disassociated 1provided by MGI
Primary source: MGI:MGI:1261820
See related: Ensembl:ENSMUSG00000020114 AllianceGenome:MGI:1261820
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tp120a; mKIAA0829; D10Ertd516e; 2310038O07Rik; 6330512O03Rik
Summary: Predicted to enable TBP-class protein binding activity. Predicted to be involved in several processes, including SCF complex assembly; positive regulation of RNA polymerase II transcription preinitiation complex assembly; and protein ubiquitination. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be part of cullin-RING ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system. Orthologous to human CAND1 (cullin associated and neddylation dissociated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 13.0), placenta adult (RPKM 11.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D2; 10 67.08 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (119034717..119075960, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (119198812..119240055, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradation.
Title: Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradation.
the adaptive exchange hypothesis, which posits that regulation of the koff of an FBP from SCF by the actions of substrate, Nedd8, and Cand1 molds the cellular repertoire of SCF complexes and that the plasticity afforded by this exchange mechanism may enable large variations in FBP expression during development and in FBP gene number during evolution.
Title: Cand1-Mediated Adaptive Exchange Mechanism Enables Variation in F-Box Protein Expression.
SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation
Title: SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI846556 (e-PCR)
- UniSTS:165725

R75103 (e-PCR)
- UniSTS:125534

AU022139 (e-PCR)
- UniSTS:167018

D1S3699 (e-PCR)
- UniSTS:474277

NoName (e-PCR)
- UniSTS:236470

AI195005 (e-PCR)
- UniSTS:185853

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables TBP-class protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in SCF complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in SCF complex assembly	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of catalytic activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of cullin-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cullin-associated NEDD8-dissociated protein 1

Names: TBP-interacting protein; cullin-associated and neddylation-dissociated protein 1; p120 CAND1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027994.1 → NP_082270.1 cullin-associated NEDD8-dissociated protein 1

See identical proteins and their annotated locations for NP_082270.1

Status: VALIDATED

Source sequence(s)

AC160063

Consensus CDS

CCDS48701.1

UniProtKB/Swiss-Prot

Q6PFR0, Q6ZQ38, Q9CV45

Related

ENSMUSP00000020315.7, ENSMUST00000020315.13

Conserved Domains (4) summary

cd00020
Location:650 → 745

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam08623
Location:1040 → 1202

TIP120; TATA-binding protein interacting (TIP20)

pfam13513
Location:149 → 202

HEAT_EZ; HEAT-like repeat

sd00044
Location:817 → 847

HEAT; HEAT repeat [structural motif]