Ighd immunoglobulin heavy constant delta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ighdprovided by MGI
Official Full Name: immunoglobulin heavy constant deltaprovided by MGI
Primary source: MGI:MGI:96447
See related: Ensembl:ENSMUSG00000104213 IMGT/GENE-DB:IGHD; AllianceGenome:MGI:96447
Gene type: other
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IgD; Igh-5
Summary: Enables antigen binding activity. Acts upstream of or within several processes, including immunoglobulin mediated immune response; positive regulation of B cell proliferation; and somatic hypermutation of immunoglobulin genes. Located in external side of plasma membrane. Part of B cell receptor complex. Orthologous to human IGHD (immunoglobulin heavy constant delta). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 12 F1; 12 62.1 cM

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (113371155..113379944, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (113407535..113416324, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

analysis of a transgenic mouse model with liver-specific expression of secretory immunoglobulin D
Title: Establishment of a transgenic mouse model with liver-specific expression of secretory immunoglobulin D.
IgD is an auxiliary antigen receptor
Title: Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells.
Mouse B cells develop and function without expressing IgD due to targeted gene inactivation
Title: Cell autonomous expression of IgD is not essential for the maturation of conventional B cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Chemically induced (ENU) (3)
Endonuclease-mediated (1)

General gene information

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Markers

AI326478 (e-PCR)
- UniSTS:180487

PMC312773P1 (e-PCR)
- UniSTS:272917

UniSTS:461920 (e-PCR)
- UniSTS:461920

Igh-6 (e-PCR), detects polymorphism
- UniSTS:461920

Igh (e-PCR), detects polymorphism
- UniSTS:143493

PMC124510P1 (e-PCR)
- UniSTS:270472

Igh-6 (e-PCR), detects polymorphism
- UniSTS:143498

Igh-C (e-PCR), detects polymorphism
- UniSTS:143500

PMC305257P2 (e-PCR)
- UniSTS:272540

D12Mit8 (e-PCR), detects polymorphism
- UniSTS:126899

M-04725 (e-PCR)
- UniSTS:186305

NoName (e-PCR)
- UniSTS:224213

Other Names

immunoglobulin delta-chain
immunoglobulin heavy chain 5 (delta-like heavy chain)

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antigen binding	IBA Inferred from Biological aspect of Ancestor more info
enables antigen binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of B cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in immunoglobulin mediated immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immunoglobulin mediated immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of B cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-1 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of immune response	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within regulation of immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somatic hypermutation of immunoglobulin genes	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of B cell receptor complex	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.