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    Plc21C Phospholipase C at 21C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33204, updated on 10-May-2024

    Summary

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    Official Symbol
    Plc21Cprovided by FlyBase
    Official Full Name
    Phospholipase C at 21Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004611
    Locus tag
    Dmel_CG4574
    See related
    AllianceGenome:FB:FBgn0004611
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4574; Dmel\CG4574; PLC; plc-21; PLC-21; PLC-21C; plc21; Plc21; plc21c; plc21C; Plc21c; PLC21c; PLC21C; plcbeta21c; Plcbeta21C; PLC[[Beta]]
    Summary
    Predicted to enable phosphatidylinositol phospholipase C activity. Involved in several processes, including entrainment of circadian clock by photoperiod; flight behavior; and regulation of neuromuscular synaptic transmission. Is expressed in central nervous system; embryonic/larval digestive system; head; oocyte; and ring gland. Used to study obesity. Human ortholog(s) of this gene implicated in Alzheimer's disease; developmental and epileptic encephalopathy 12; myelodysplastic syndrome; and spondylometaphyseal dysplasia with corneal dystrophy. Orthologous to several human genes including PLCB1 (phospholipase C beta 1) and PLCB3 (phospholipase C beta 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    Location:
    21B8-21C1; 2-0.7 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (305935..355566)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (305935..355566)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Stress induced phosphoprotein 1 Neighboring gene Pi3K21B Neighboring gene long non-coding RNA:CR43719 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45367 Neighboring gene antisense RNA:CR45366 Neighboring gene Equilibrative nucleoside transporter 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of the droPIK57 gene encoding a new regulatory subunit of phosphatidylinositol 3-kinase from Drosophila melanogaster. Albert S, et al. Gene, 1997 Oct 1. PMID 9370280
    2. Receptor-evoked Cl- current in Xenopus oocytes is mediated through a beta-type phospholipase C. Cloning of a new form of the enzyme. Ma HW, et al. J Biol Chem, 1993 Sep 25. PMID 8397190
    3. Multiple subtypes of phospholipase C are encoded by the norpA gene of Drosophila melanogaster. Kim S, et al. J Biol Chem, 1995 Jun 16. PMID 7540168
    4. A Drosophila phospholipase C gene that is expressed in the central nervous system. Shortridge RD, et al. J Biol Chem, 1991 Jul 5. PMID 2061323
    5. Drosophila Plc21C is involved in calcium wave propagation during egg activation. Hu Q, et al. MicroPubl Biol, 2020 Apr 1. PMID 32550503, Free PMC Article

    See all (112) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Light Sampling via Throttled Visual Phototransduction Robustly Synchronizes the Drosophila Circadian Clock.
      Title: Light Sampling via Throttled Visual Phototransduction Robustly Synchronizes the Drosophila Circadian Clock.
    2. Galphaq, Ggamma1 and Plc21C are anti-obesity genes and Akh employs the Galphaq/Ggamma1/Plc21C module of iCa(2+) control to regulate lipid mobilization in adult Drosophila.
      Title: Gαq, Gγ1 and Plc21C control Drosophila body fat storage.
    3. Disruption of PLCb4 function completely blocked light-dependent modulation of Shab currents in Drosophila photoreceptors.
      Title: Light-dependent modulation of Shab channels via phosphoinositide depletion in Drosophila photoreceptors.
    4. Reduced odor responses from antennal neurons of phospholipase Cbeta mutants in Drosophila support a role for a phospholipid intermediate in insect olfactory transduction.
      Title: Reduced odor responses from antennal neurons of G(q)alpha, phospholipase Cbeta, and rdgA mutants in Drosophila support a role for a phospholipid intermediate in insect olfactory transduction.
    5. These results are consistent with a model in which phosphatidylinositol 4,5-bisphosphate hydrolysis acts via Ca2+ to activate myosin via MLCK and thereby control actin dynamics during constriction of the contractile ring.
      Title: Phospholipase C and myosin light chain kinase inhibition define a common step in actin regulation during cytokinesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in entrainment of circadian clock by photoperiod IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in flight behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron cellular homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phosphatidylinositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neuromuscular synaptic transmission IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phospholipase C at 21C
    Names
    CG4574-PA
    CG4574-PB
    CG4574-PC
    CG4574-PD
    CG4574-PG
    CG4574-PH
    Plc21C-PA
    Plc21C-PB
    Plc21C-PC
    Plc21C-PD
    Plc21C-PG
    Plc21C-PH
    phospholipase C
    phospholipase C 21C
    phospholipase c at 21c
    NP_001259818.1
    NP_476851.2
    NP_476852.1
    NP_995604.2
    NP_995605.1
    NP_995606.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      305935..355566
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_205884.3 → NP_995606.1  phospholipase C at 21C, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995606.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25455
      Conserved Domains (5) summary
      cd00275
      Location:736 → 855
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:317 → 702
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02222
      Location:213 → 850
      PLN02222; phosphoinositide phospholipase C 2
      cd13361
      Location:20 → 145
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam09279
      Location:225 → 317
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

    2. NM_057504.5 → NP_476852.1  phospholipase C at 21C, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476852.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25455
      Related
      FBpp0077710
      Conserved Domains (5) summary
      cd00275
      Location:736 → 855
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:317 → 702
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02222
      Location:213 → 850
      PLN02222; phosphoinositide phospholipase C 2
      cd13361
      Location:20 → 145
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam09279
      Location:225 → 317
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

    3. NM_001272889.1 → NP_001259818.1  phospholipase C at 21C, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259818.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25455
      Conserved Domains (4) summary
      cd00275
      Location:675 → 794
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:299 → 641
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:20 → 145
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam09279
      Location:225 → 299
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

    4. NM_205883.2 → NP_995605.1  phospholipase C at 21C, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995605.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZX5, M9PC05, P25455, Q0E8V1, Q7KTZ7, Q961D5, Q9VPN9
      Conserved Domains (5) summary
      cd00275
      Location:736 → 855
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:317 → 702
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02222
      Location:213 → 850
      PLN02222; phosphoinositide phospholipase C 2
      cd13361
      Location:20 → 145
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam09279
      Location:225 → 317
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

    5. NM_057503.5 → NP_476851.2  phospholipase C at 21C, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476851.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25455
      Related
      FBpp0077711
      Conserved Domains (5) summary
      cd00275
      Location:736 → 855
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:317 → 702
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02222
      Location:213 → 850
      PLN02222; phosphoinositide phospholipase C 2
      cd13361
      Location:20 → 145
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam09279
      Location:225 → 317
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

    6. NM_205882.2 → NP_995604.2  phospholipase C at 21C, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995604.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25455
      Conserved Domains (5) summary
      cd00275
      Location:736 → 855
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:317 → 702
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02222
      Location:213 → 850
      PLN02222; phosphoinositide phospholipase C 2
      cd13361
      Location:20 → 145
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam09279
      Location:225 → 317
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25455.3 P25455

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