FPR3 formyl peptide receptor 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FPR3provided by HGNC
Official Full Name: formyl peptide receptor 3provided by HGNC
Primary source: HGNC:HGNC:3828
See related: Ensembl:ENSG00000187474 MIM:136539; AllianceGenome:HGNC:3828
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FMLPY; FPRH1; FPRH2; FPRL2; RMLP-R-I; FMLP-R-II; FML2_HUMAN
Summary: Predicted to enable N-formyl peptide receptor activity and complement receptor activity. Predicted to be involved in several processes, including complement receptor mediated signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in appendix (RPKM 15.7), gall bladder (RPKM 12.8) and 22 other tissues See more
Orthologs: all
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Genomic context

Location:: 19q13.41

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (51795157..51826190)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (54882351..54913384)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (52298410..52329443)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Formyl peptide receptor 2 is an emerging modulator of inflammation in the liver.
Title: Formyl peptide receptor 2 is an emerging modulator of inflammation in the liver.
D-Peptide analogues of Boc-Phe-Leu-Phe-Leu-Phe-COOH induce neovascularization via endothelial N-formyl peptide receptor 3.
Title: D-Peptide analogues of Boc-Phe-Leu-Phe-Leu-Phe-COOH induce neovascularization via endothelial N-formyl peptide receptor 3.
Low FPR3 expression is associated with obstructive sleep apnea.
Title: Formyl peptide receptor 1 up-regulation and formyl peptide receptor 2/3 down-regulation of blood immune cells along with defective lipoxin A4/resolvin D1 production in obstructive sleep apnea patients.
These findings provide evidence for defective FPR2/3 and annexin A1 expressions that, associated with decreased M2a polarization, might be involved in the development of cigarette smoking induced persistent airflow limitation in chronic obstructive pulmonary disease.
Title: Defective formyl peptide receptor 2/3 and annexin A1 expressions associated with M2a polarization of blood immune cells in patients with chronic obstructive pulmonary disease.
Taken together, our results suggest that intracellular FPR in naive CD4 T cells and surface FPRs in activated CD4 T cells might regulate immune responses by regulating CD4 T cell activity.
Title: Intracellular formyl peptide receptor regulates naïve CD4 T cell migration.
The demonstrated proper folding and functionality of the cell-free produced human FPR3 opens a new avenue for the fast and efficient generation of human FPRs (and even other GPCRs) for structural and functional analysis.
Title: Evaluation of cell-free expression system for the production of soluble and functional human GPCR N-formyl peptide receptors.
The H. pylori-derived peptide Hp(2-20) stimulated eosinophil migration through the engagement of FPR2 and FPR3, and also induced production of VEGF-A and TGF-beta, two key mediators of tissue remodelling.
Title: Helicobacter pylori HP(2-20) induces eosinophil activation and accumulation in superficial gastric mucosa and stimulates VEGF-alpha and TGF-beta release by interacting with formyl-peptide receptors.
transcriptional variations of FPR3 occur by an alternative promoter during primate evolution.
Title: Transcriptional variations mediated by an alternative promoter of the FPR3 gene.
F2L peptide, derived from the processing of nanomolar concentrations of heme-binding protein (HEBP)1, is active on FPR3 and able to induce recruitment of FPR3-expressing monocytes, macrophages, and mouse neutrophils
Title: Processing of HEBP1 by cathepsin D gives rise to F2L, the agonist of formyl peptide receptor 3.
N-formyl peptide receptor 3 (FPR3) departs from the homologous FPR2/ALX receptor with regard to the major processes governing chemoattractant receptor regulation, expression at the cell surface, and phosphorylation.
Title: N-formyl peptide receptor 3 (FPR3) departs from the homologous FPR2/ALX receptor with regard to the major processes governing chemoattractant receptor regulation, expression at the cell surface, and phosphorylation.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Discovery and refinement of loci associated with lipid levels. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

PMC17875P1 (e-PCR)
- UniSTS:271650

PMC17875P2 (e-PCR)
- UniSTS:271651

PMC17875P3 (e-PCR)
- UniSTS:271652

PMC17875P4 (e-PCR)
- UniSTS:271653

RH71357 (e-PCR)
- UniSTS:78657

RH99009 (e-PCR)
- UniSTS:84033

RH79920 (e-PCR)
- UniSTS:85071

SHGC-32473 (e-PCR)
- UniSTS:37335

NoName (e-PCR)
- UniSTS:481014

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables N-formyl peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables complement receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in complement receptor mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: N-formyl peptide receptor 3

Names: FMLP-related receptor II; formyl peptide receptor-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002030.5 → NP_002021.3 N-formyl peptide receptor 3

See identical proteins and their annotated locations for NP_002021.3

Status: VALIDATED

Source sequence(s)

AI301735, AK123030, BC059388, CB996360, DA844883

Consensus CDS

CCDS12841.1

UniProtKB/Swiss-Prot

P25089

UniProtKB/TrEMBL

Q6L5J4

Related

ENSP00000341821.3, ENST00000339223.5

Conserved Domains (2) summary

cd14964
Location:29 → 53

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:27 → 313

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

51795157..51826190

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011526687.3 → XP_011524989.1 N-formyl peptide receptor 3 isoform X1

See identical proteins and their annotated locations for XP_011524989.1

UniProtKB/Swiss-Prot

P25089

UniProtKB/TrEMBL

Q6L5J4

Related

ENSP00000470471.1, ENST00000595991.1

Conserved Domains (2) summary

cd14964
Location:29 → 53

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:27 → 313

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily