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    tra2 transformer 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36619, updated on 10-May-2024

    Summary

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    Official Symbol
    tra2provided by FlyBase
    Official Full Name
    transformer 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0003742
    Locus tag
    Dmel_CG10128
    See related
    AllianceGenome:FB:FBgn0003742
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10128; Dmel\CG10128; TRA 2; tra-2; Tra-2; TRA-2; Tra2; TRA2
    Summary
    Enables identical protein binding activity and pre-mRNA binding activity. Involved in female sex determination; mRNA splicing, via spliceosome; and regulation of alternative mRNA splicing, via spliceosome. Part of precatalytic spliceosome. Is expressed in several structures, including embryonic epipharynx; germline cell; gonad; and labral sensory complex. Orthologous to human TRA2A (transformer 2 alpha homolog) and TRA2B (transformer 2 beta homolog). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See tra2 in Genome Data Viewer
    Location:
    51B6-51B6; 2-72 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14602004..14604337, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10489509..10491842, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene tout-velu Neighboring gene Lamin C Neighboring gene uncharacterized protein Neighboring gene small Cajal body-specific RNA : PsiU5-44 Neighboring gene RNA polymerase I subunit A Neighboring gene Biogenesis of lysosome-related organelles complex 1, subunit 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The splicing factor transformer2 (tra2) functions in the Drosophila fat body to regulate lipid storage. Mikoluk C, et al. Biochem Biophys Res Commun, 2018 Jan 1. PMID 29203241, Free PMC Article
    2. Gradual acquisition of the developmental capacity to differentiate adult structures by the genital disc of Drosophila melanogaster. Sánchez L, et al. Rouxs Arch Dev Biol, 1992 Apr. PMID 28305899
    3. X Chromosome and Autosome Dosage Responses in Drosophila melanogaster Heads. Chen ZX, et al. G3 (Bethesda), 2015 Apr 7. PMID 25850426, Free PMC Article
    4. The gene transformer-2 of Sciara (Diptera, Nematocera) and its effect on Drosophila sexual development. Martín I, et al. BMC Dev Biol, 2011 Mar 15. PMID 21406087, Free PMC Article
    5. Concentration dependent selection of targets by an SR splicing regulator results in tissue-specific RNA processing. Qi J, et al. Nucleic Acids Res, 2006. PMID 17098939, Free PMC Article

    See all (285) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Together, these results suggest a link between mRNA splicing, sex determination and lipid metabolism and may provide insight into the mechanisms underlying tissue-specific splicing and nutrient storage.
      Title: The splicing factor transformer2 (tra2) functions in the Drosophila fat body to regulate lipid storage.
    2. results indicate the Hfp/Puf68 protein is required for the negative regulation of splicing by Tra2
      Title: Half pint/Puf68 is required for negative regulation of splicing by the SR splicing factor Transformer2.
    3. Anastrepha Tra2 protein supplies tra-2 function in Drosophila
      Title: Effect of the transformer-2 gene of Anastrepha on the somatic sexual development of Drosophila.
    4. Tra2 represses M1 splicing by interacting with multiple sequences in the pre-mRNA and interfering with enhancer function
      Title: Direct repression of splicing by transformer-2.
    5. Rbp1 and Tra2 bind to the ISS independently through distinct sequences suggesting that functionally synergistic interactions of these SR factors can cause either splicing activation or repression.
      Title: The doublesex splicing enhancer components Tra2 and Rbp1 also repress splicing through an intronic silencer.
    6. Here we show that that widely used tra2 mutant alleles have residual activity and are not suitable for evaluating its effect on viability.
      Title: Analysis of a null mutation in the Drosophila splicing regulator Tra2 suggests its function is restricted to sexual differentiation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pre-mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in female sex determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female somatic sex determination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in male somatic sex determination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reproductive process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in sex determination NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in spermatogenesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in spliceosomal complex assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of precatalytic spliceosome HDA PubMed 
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transformer 2
    Names
    CG10128-PA
    CG10128-PB
    CG10128-PC
    CG10128-PD
    CG10128-PE
    CG10128-PF
    CG10128-PG
    Transformer-2
    tra2-PA
    tra2-PB
    tra2-PC
    tra2-PD
    tra2-PE
    tra2-PF
    tra2-PG
    transformer2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14602004..14604337 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057416.3 → NP_476764.1  transformer 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476764.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZH1, P19018, Q0E977, Q9V734
      Related
      FBpp0088562
      Conserved Domains (2) summary
      COG0724
      Location:74 → 242
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12363
      Location:98 → 175
      RRM_TRA2; RNA recognition motif in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

    2. NM_057415.3 → NP_476763.1  transformer 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476763.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P19018
      Related
      FBpp0088563
      Conserved Domains (1) summary
      cl17169
      Location:98 → 133
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_057417.3 → NP_476765.1  transformer 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476765.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P19018
      Related
      FBpp0088564
      Conserved Domains (2) summary
      COG0724
      Location:36 → 204
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12363
      Location:60 → 137
      RRM_TRA2; RNA recognition motif in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

    4. NM_206113.2 → NP_995835.1  transformer 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995835.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZH1, P19018, Q0E977, Q9V734
      Conserved Domains (2) summary
      COG0724
      Location:74 → 242
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12363
      Location:98 → 175
      RRM_TRA2; RNA recognition motif in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

    5. NM_206112.2 → NP_995834.1  transformer 2, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995834.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZH1, P19018, Q0E977, Q9V734
      Conserved Domains (2) summary
      COG0724
      Location:74 → 242
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12363
      Location:98 → 175
      RRM_TRA2; RNA recognition motif in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

    6. NM_134280.1 → NP_599107.1  transformer 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_599107.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P19018
      Related
      FBpp0088560, FBtr0089615
      Conserved Domains (2) summary
      COG0724
      Location:36 → 204
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12363
      Location:60 → 137
      RRM_TRA2; RNA recognition motif in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

    7. NM_057418.2 → NP_476766.1  transformer 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476766.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P19018
      Related
      FBpp0088561, FBtr0089616
      Conserved Domains (2) summary
      COG0724
      Location:3 → 157
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12363
      Location:13 → 90
      RRM_TRA2; RNA recognition motif in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19018.1 P19018

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