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    sh2b1 SH2B adaptor protein 1 [ Danio rerio (zebrafish) ]

    Gene ID: 558152, updated on 27-Mar-2024

    Summary

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    Official Symbol
    sh2b1provided by ZNC
    Official Full Name
    SH2B adaptor protein 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070209-188
    See related
    Ensembl:ENSDARG00000057679 AllianceGenome:ZFIN:ZDB-GENE-070209-188
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:158474
    Summary
    Predicted to enable transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be active in plasma membrane. Orthologous to human SH2B1 (SH2B adaptor protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (15358430..15392467)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (15208632..15242666)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103910227 Neighboring gene phosphatidylinositol transfer protein, beta, like Neighboring gene ataxin 2-like Neighboring gene si:dkey-56d12.4 Neighboring gene linker for activation of T cells

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables signaling adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SH2B adapter protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110455.1 → NP_001103925.1  SH2B adapter protein 1

      See identical proteins and their annotated locations for NP_001103925.1

      Status: PROVISIONAL

      Source sequence(s)
      BC133102
      UniProtKB/TrEMBL
      A0A0R4IQ02, A0A8M6YW84, A2RUZ0
      Related
      ENSDARP00000078411.3, ENSDART00000083976.4
      Conserved Domains (4) summary
      cd10346
      Location:707 → 802
      SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
      cd01231
      Location:490 → 613
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam00169
      Location:511 → 610
      PH; PH domain
      pfam08916
      Location:71 → 125
      Phe_ZIP; Phenylalanine zipper

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      15358430..15392467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017354352.2 → XP_017209841.1  SH2B adapter protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0R4IQ02, A0A8M6YW84, A2RUZ0
      Related
      ENSDARP00000115931.1, ENSDART00000141808.3
      Conserved Domains (4) summary
      cd10346
      Location:707 → 802
      SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
      cd01231
      Location:490 → 613
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam00169
      Location:511 → 610
      PH; PH domain
      pfam08916
      Location:71 → 125
      Phe_ZIP; Phenylalanine zipper

    2. XM_017354353.2 → XP_017209842.1  SH2B adapter protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0R4IQ02, A0A8M6YW84, A2RUZ0
      Conserved Domains (4) summary
      cd10346
      Location:707 → 802
      SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
      cd01231
      Location:490 → 613
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam00169
      Location:511 → 610
      PH; PH domain
      pfam08916
      Location:71 → 125
      Phe_ZIP; Phenylalanine zipper

    3. XM_005163818.4 → XP_005163875.1  SH2B adapter protein 1 isoform X2

      See identical proteins and their annotated locations for XP_005163875.1

      UniProtKB/TrEMBL
      A0A8M2BAY6
      Conserved Domains (4) summary
      cd10346
      Location:707 → 802
      SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
      cd01231
      Location:490 → 613
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam00169
      Location:511 → 610
      PH; PH domain
      pfam08916
      Location:71 → 125
      Phe_ZIP; Phenylalanine zipper

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394524.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      14773..46360
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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