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    Adamtsl1 ADAMTS-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 77739, updated on 12-May-2024

    Summary

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    Official Symbol
    Adamtsl1provided by MGI
    Official Full Name
    ADAMTS-like 1provided by MGI
    Primary source
    MGI:MGI:1924989
    See related
    Ensembl:ENSMUSG00000066113 AllianceGenome:MGI:1924989
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ADAMTSL-1; 5930437A14Rik; 6720426B09Rik
    Summary
    Predicted to be involved in extracellular matrix organization. Located in collagen-containing extracellular matrix. Orthologous to human ADAMTSL1 (ADAMTS like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 6.7), limb E14.5 (RPKM 4.3) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 C4; 4 40.32 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (85432242..86346627)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (85513852..86428390)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10676 Neighboring gene STARR-seq mESC enhancer starr_10677 Neighboring gene STARR-seq mESC enhancer starr_10679 Neighboring gene RAN, member RAS oncogene family pseudogene Neighboring gene SH3-domain GRB2-like 2 Neighboring gene phosphoglycerate mutase 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_10684 Neighboring gene STARR-seq mESC enhancer starr_10685 Neighboring gene STARR-seq mESC enhancer starr_10686 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-seq mESC enhancer starr_10687 Neighboring gene predicted gene, 25811 Neighboring gene STARR-seq mESC enhancer starr_10689 Neighboring gene STARR-seq mESC enhancer starr_10690 Neighboring gene STARR-seq mESC enhancer starr_10691 Neighboring gene STARR-seq mESC enhancer starr_10692 Neighboring gene STARR-seq mESC enhancer starr_10693 Neighboring gene predicted gene, 33730 Neighboring gene STARR-positive B cell enhancer mm9_chr4:86183948-86184249 Neighboring gene stabilizer of axonemal microtubules 1 Neighboring gene predicted gene, 26017 Neighboring gene stabilizer of axonemal microtubules 1, opposite strand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix. Hirohata S, et al. J Biol Chem, 2002 Apr 5. PMID 11805097
    2. ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases. Hall NG, et al. Matrix Biol, 2003 Nov. PMID 14667842
    3. O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Du J, et al. Dev Biol, 2010 Oct 1. PMID 20637190, Free PMC Article
    4. The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Naba A, et al. Mol Cell Proteomics, 2012 Apr. PMID 22159717, Free PMC Article
    5. Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Naba A, et al. Sci Rep, 2017 Jan 10. PMID 28071719, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ADAMTS-like protein 1
    Names
    punctin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368621.1 → NP_001355550.1  ADAMTS-like protein 1 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL772130, AL807242, AL824705
      UniProtKB/Swiss-Prot
      A2AM52, Q8BLI0
      Related
      ENSMUSP00000119278.2, ENSMUST00000141889.8
      Conserved Domains (7) summary
      smart00408
      Location:891 → 949
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:36 → 82
      TSP1; Thrombospondin type 1 repeats
      PTZ00441
      Location:434 → 506
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      cd00096
      Location:1304 → 1375
      Ig; Immunoglobulin domain
      cl15278
      Location:529 → 583
      TSP_1; Thrombospondin type 1 domain
      pfam07679
      Location:1414 → 1494
      I-set; Immunoglobulin I-set domain
      pfam08686
      Location:1738 → 1767
      PLAC; PLAC (protease and lacunin) domain

    2. NM_029967.3 → NP_084243.3  ADAMTS-like protein 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AK020115, AK045085, AK132420, AL807242, AL824705, CJ051149, CV555842
      Consensus CDS
      CCDS51217.1
      UniProtKB/Swiss-Prot
      A2AM52, Q8BLI0
      UniProtKB/TrEMBL
      E9PWW5
      Related
      ENSMUSP00000102796.3, ENSMUST00000107178.9
      Conserved Domains (6) summary
      smart00408
      Location:1284 → 1351
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:36 → 82
      TSP1; Thrombospondin type 1 repeats
      smart00410
      Location:1269 → 1361
      IG_like; Immunoglobulin like
      pfam08686
      Location:1721 → 1750
      PLAC; PLAC (protease and lacunin) domain
      cl11960
      Location:1180 → 1240
      Ig; Immunoglobulin domain
      cl15278
      Location:514 → 566
      TSP_1; Thrombospondin type 1 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      85432242..86346627
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538375.3 → XP_006538438.1  ADAMTS-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A2AM52, Q8BLI0
      Conserved Domains (6) summary
      smart00408
      Location:1647 → 1713
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:265 → 311
      TSP1; Thrombospondin type 1 repeats
      PTZ00441
      Location:663 → 735
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      cd00096
      Location:1533 → 1604
      Ig; Immunoglobulin domain
      pfam08686
      Location:1967 → 1996
      PLAC; PLAC (protease and lacunin) domain
      cl15278
      Location:760 → 812
      TSP_1; Thrombospondin type 1 domain

    2. XM_006538376.3 → XP_006538439.1  ADAMTS-like protein 1 isoform X2

      UniProtKB/Swiss-Prot
      A2AM52, Q8BLI0
      Conserved Domains (5) summary
      smart00408
      Location:1630 → 1696
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:265 → 311
      TSP1; Thrombospondin type 1 repeats
      PTZ00441
      Location:646 → 718
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      cd00096
      Location:1516 → 1587
      Ig; Immunoglobulin domain
      cl15278
      Location:743 → 795
      TSP_1; Thrombospondin type 1 domain

    3. XM_036164549.1 → XP_036020442.1  ADAMTS-like protein 1 isoform X3

      UniProtKB/Swiss-Prot
      A2AM52, Q8BLI0
      Conserved Domains (7) summary
      smart00408
      Location:1078 → 1136
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:223 → 269
      TSP1; Thrombospondin type 1 repeats
      pfam08686
      Location:1925 → 1954
      PLAC; PLAC (protease and lacunin) domain
      pfam13927
      Location:1472 → 1552
      Ig_3; Immunoglobulin domain
      pfam19030
      Location:857 → 915
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cd00096
      Location:1491 → 1495
      Ig; Ig strand B [structural motif]
      cl11960
      Location:1384 → 1444
      Ig; Immunoglobulin domain

    4. XM_006538378.5 → XP_006538441.1  ADAMTS-like protein 1 isoform X4

      See identical proteins and their annotated locations for XP_006538441.1

      UniProtKB/Swiss-Prot
      A2AM52, Q8BLI0
      Conserved Domains (5) summary
      smart00408
      Location:1418 → 1484
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:36 → 82
      TSP1; Thrombospondin type 1 repeats
      PTZ00441
      Location:434 → 506
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      cd00096
      Location:1304 → 1375
      Ig; Immunoglobulin domain
      cl15278
      Location:531 → 583
      TSP_1; Thrombospondin type 1 domain

    5. XM_036164550.1 → XP_036020443.1  ADAMTS-like protein 1 isoform X5

      UniProtKB/Swiss-Prot
      A2AM52, Q8BLI0
      Conserved Domains (6) summary
      smart00408
      Location:874 → 932
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:36 → 82
      TSP1; Thrombospondin type 1 repeats
      pfam13927
      Location:1268 → 1348
      Ig_3; Immunoglobulin domain
      pfam19030
      Location:653 → 711
      TSP1_ADAMTS; Thrombospondin type 1 domain
      cd00096
      Location:1287 → 1291
      Ig; Ig strand B [structural motif]
      cl11960
      Location:1180 → 1240
      Ig; Immunoglobulin domain

    6. XM_030253919.2 → XP_030109779.1  ADAMTS-like protein 1 isoform X6

      Conserved Domains (4) summary
      smart00408
      Location:950 → 1016
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:322 → 381
      TSP1; Thrombospondin type 1 repeats
      cd00096
      Location:836 → 907
      Ig; Immunoglobulin domain
      cl15278
      Location:63 → 115
      TSP_1; Thrombospondin type 1 domain

    7. XM_006538380.3 → XP_006538443.1  ADAMTS-like protein 1 isoform X6

      See identical proteins and their annotated locations for XP_006538443.1

      Conserved Domains (4) summary
      smart00408
      Location:950 → 1016
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:322 → 381
      TSP1; Thrombospondin type 1 repeats
      cd00096
      Location:836 → 907
      Ig; Immunoglobulin domain
      cl15278
      Location:63 → 115
      TSP_1; Thrombospondin type 1 domain

    8. XM_006538379.4 → XP_006538442.1  ADAMTS-like protein 1 isoform X6

      See identical proteins and their annotated locations for XP_006538442.1

      Conserved Domains (4) summary
      smart00408
      Location:950 → 1016
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:322 → 381
      TSP1; Thrombospondin type 1 repeats
      cd00096
      Location:836 → 907
      Ig; Immunoglobulin domain
      cl15278
      Location:63 → 115
      TSP_1; Thrombospondin type 1 domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172542.1: Suppressed sequence

      Description
      NM_172542.1: This RefSeq was permanently suppressed because the CDS was partial.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BLI0.2 GenPept UniProtKB/Swiss-Prot:Q8BLI0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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