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    Lapsyn Leucine-rich repeat activity-regulated protein at synapses [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37418, updated on 26-Apr-2024

    Summary

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    Official Symbol
    Lapsynprovided by FlyBase
    Official Full Name
    Leucine-rich repeat activity-regulated protein at synapsesprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034602
    Locus tag
    Dmel_CG15658
    See related
    AllianceGenome:FB:FBgn0034602
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15658; CT35842; Dmel\CG15658
    Summary
    Involved in nervous system development. Located in neuronal cell body. Colocalizes with presynaptic membrane. Is expressed in several structures, including adult head; embryonic/larval gut; embryonic/larval midgut primordium; posterior ectoderm anlage; and yolk nucleus. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; human immunodeficiency virus infectious disease; liver cirrhosis; and type 1 diabetes mellitus. Orthologous to human TLR3 (toll like receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    57C9-57D1; 2-93 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21193571..21199431)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17081076..17086936)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Glycine-GCC 1-13 Neighboring gene tudor Neighboring gene uncharacterized protein Neighboring gene Glycogenin Neighboring gene UDP-glycosyltransferase family 49 member B1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lapsyn controls branch extension and positioning of astrocyte-like glia in the Drosophila optic lobe. Richier B, et al. Nat Commun, 2017 Aug 22. PMID 28827667, Free PMC Article
    2. Selection, recombination and demographic history in Drosophila miranda. Bachtrog D, et al. Genetics, 2006 Dec. PMID 17028331, Free PMC Article
    3. Neuron-glia interaction in the Drosophila nervous system. Bittern J, et al. Dev Neurobiol, 2021 Jul. PMID 32096904
    4. Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage. Brodsky MH, et al. Mol Cell Biol, 2004 Feb. PMID 14729967, Free PMC Article
    5. Identification of genes expressed during Drosophila melanogaster gastrulation by using subtractive hybridization. González-Agüero M, et al. Gene, 2005 Jan 31. PMID 15716118

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Leucine-rich repeat activity-regulated protein at synapses
    Names
    CG15658-PA
    Lapsyn-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21193571..21199431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137717.4 → NP_611561.1  Leucine-rich repeat activity-regulated protein at synapses [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611561.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961I0, Q9W2J7
      Related
      FBpp0071509
      Conserved Domains (4) summary
      cd00116
      Location:94 → 249
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:39 → 59
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:106 → 145
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:58 → 118
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W2J7 Q9W2J7

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