OSCP1 organic solute carrier partner 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: OSCP1provided by HGNC
Official Full Name: organic solute carrier partner 1provided by HGNC
Primary source: HGNC:HGNC:29971
See related: Ensembl:ENSG00000116885 MIM:608854; AllianceGenome:HGNC:29971
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NOR1; C1orf102
Summary: Enables transmembrane transporter activity. Involved in xenobiotic detoxification by transmembrane export across the plasma membrane. Located in basal plasma membrane and cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis (RPKM 27.5), thyroid (RPKM 6.0) and 13 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p34.3

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (36417906..36450451, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (36280766..36313305, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (36883507..36916052, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Abberant expression of NOR1 protein in tumor associated macrophages contributes to the development of DEN-induced hepatocellular carcinoma.
Title: Abberent expression of NOR1 protein in tumor associated macrophages contributes to the development of DEN-induced hepatocellular carcinoma.
Results identified NOR1 as a downstream target gene of miR-199a which is critical for regulating cell proliferation and migration by targeting and upregulating NOR1 in human HepG2 cells.
Title: MicroRNA-199a-5p inhibits VEGF-induced tumorigenesis through targeting oxidored-nitro domain-containing protein 1 in human HepG2 cells.
Data revealed novel aspects of the interplay between autophagy and apoptosis in nasopharyngeal carcinoma cells, which underlies the tumor suppression function of NOR1.
Title: Tumor suppressor gene Oxidored-nitro domain-containing protein 1 regulates nasopharyngeal cancer cell autophagy, metabolism, and apoptosis in vitro.
Frequent epigenetic inactivation of the NOR1 gene in nasopharyngeal carcinoma (NPC) suggests that it may be a critical tumor suppressor involved in the development of nasopharyngeal carcinoma.
Title: NOR1 is an HSF1- and NRF1-regulated putative tumor suppressor inactivated by promoter hypermethylation in nasopharyngeal carcinoma.
NOR1 protein is predominantly expressed in human nasopharynx and tracheal tissues and is frequently down-expressed in NPC.
Title: Preparation of polyclonal antibody specific for NOR1 and detection of its expression pattern in human tissues and nasopharyngeal carcinoma.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
NOR(1) gene may have some effects on liver cancer by up-regulating the expression of these proteins.
Title: [Effects of a novel gene NOR(1) on the protein expression of HepG2 cell line].
We cloned a novel gene NOR(1), and the Glu58Gly polymorphism of NOR(1) may be involved in the development and/or progression of NPC suggesting that NOR(1) could be a candidate tumor repressor gene related with NPC.
Title: Cloning, expression, and mutation analysis of NOR1, a novel human gene down-regulated in HNE1 nasopharyngeal carcinoma cell line.
hOSCP1 is a novel polyspecific organic solute carrier protein responsible for drug clearance from the human placenta
Title: Isolation and functional characterization of a novel organic solute carrier protein, hOSCP1.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide meta-analysis for severe diabetic retinopathy. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein OSCP1

Names: organic solute carrier protein 1; organic solute transport protein 1; oxidored nitro domain containing protein; oxidored-nitro domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001330493.2 → NP_001317422.1 protein OSCP1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).

Source sequence(s)

AC119675

Consensus CDS

CCDS81301.1

UniProtKB/Swiss-Prot

A6NHM5, A6NHS9, A6NIN9, Q4AEJ0, Q8N7G2, Q8TDF1, Q8WVF1

UniProtKB/TrEMBL

C9JF58

Related

ENSP00000349052.5, ENST00000356637.9
NM_145047.5 → NP_659484.4 protein OSCP1 isoform 1

See identical proteins and their annotated locations for NP_659484.4

Status: VALIDATED

Description

Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3.

Source sequence(s)

AW136490, BC018069, DA297022

Consensus CDS

CCDS409.2

UniProtKB/TrEMBL

C9JF58

Related

ENSP00000235532.5, ENST00000235532.9

Conserved Domains (1) summary

pfam10188
Location:18 → 189

Oscp1; Organic solute transport protein 1
NM_206837.3 → NP_996668.1 protein OSCP1 isoform 2

See identical proteins and their annotated locations for NP_996668.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon and differs in the 3' coding region and 3' UTR compared to variant 3. The resulting isoform (2) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 3.

Source sequence(s)

AF086535, BU854079, CN430132, DA297022

Consensus CDS

CCDS410.1

UniProtKB/Swiss-Prot

Q8WVF1

Related

ENSP00000346216.3, ENST00000354267.3

Conserved Domains (1) summary

pfam10188
Location:18 → 172

Oscp1; Organic solute transport protein 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

36417906..36450451 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005270462.2 → XP_005270519.1 protein OSCP1 isoform X3

UniProtKB/TrEMBL

H7C0S2

Related

ENSP00000396417.3, ENST00000445843.7

Conserved Domains (1) summary

pfam10188
Location:18 → 199

Oscp1; Organic solute transport protein 1
XM_011540681.4 → XP_011538983.1 protein OSCP1 isoform X2

UniProtKB/TrEMBL

C9JF58

Conserved Domains (1) summary

pfam10188
Location:10 → 161

Oscp1; Organic solute transport protein 1
XM_011540680.3 → XP_011538982.1 protein OSCP1 isoform X1

UniProtKB/TrEMBL

C9JF58

Conserved Domains (1) summary

pfam10188
Location:17 → 171

Oscp1; Organic solute transport protein 1
XM_047445746.1 → XP_047301702.1 protein OSCP1 isoform X6
XM_047445744.1 → XP_047301700.1 protein OSCP1 isoform X5
XM_005270463.4 → XP_005270520.1 protein OSCP1 isoform X4

Conserved Domains (1) summary

pfam10188
Location:18 → 182

Oscp1; Organic solute transport protein 1