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    Npl N-acetylneuraminate pyruvate lyase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304860, updated on 2-May-2024

    Summary

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    Official Symbol
    Nplprovided by RGD
    Official Full Name
    N-acetylneuraminate pyruvate lyaseprovided by RGD
    Primary source
    RGD:1549702
    See related
    Ensembl:ENSRNOG00000002775 AllianceGenome:RGD:1549702
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable N-acetylneuraminate lyase activity and identical protein binding activity. Predicted to be involved in N-acetylneuraminate catabolic process. Predicted to be located in cytoplasm. Orthologous to human NPL (N-acetylneuraminate pyruvate lyase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 93.0), Spleen (RPKM 66.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Npl in Genome Data Viewer
    Location:
    13q21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (68205602..68247940, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (65655099..65697464, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (70938073..70981179, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene SHC binding and spindle associated 1 like Neighboring gene DExH-box helicase 9 Neighboring gene S100 calcium binding protein A11, pseudogene 1 Neighboring gene regulator of G-protein signaling 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The sialate-pyruvate lyase from pig kidney. Elucidation of the primary structure and expression of recombinant enzyme activity. Traving C, et al. Eur J Biochem, 2001 Dec. PMID 11737202
    2. Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid. Bergfeld AK, et al. J Biol Chem, 2012 Aug 17. PMID 22692205, Free PMC Article
    3. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetylneuraminate lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetylneuraminate lyase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N-acetylneuraminate lyase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxo-acid-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acetylneuraminate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-acetylneuraminate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in N-acetylneuraminate catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-acetylneuraminate catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-acetylneuraminate lyase
    Names
    N-acetylneuraminic acid aldolase
    NALase
    sialate lyase
    sialate-pyruvate lyase
    sialic acid aldolase
    sialic acid lyase
    NP_001014006.1
    XP_006250059.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013984.1 → NP_001014006.1  N-acetylneuraminate lyase

      See identical proteins and their annotated locations for NP_001014006.1

      Status: PROVISIONAL

      Source sequence(s)
      BC082004
      UniProtKB/Swiss-Prot
      Q66H59
      UniProtKB/TrEMBL
      A0A8L2Q119
      Related
      ENSRNOP00000097337.1, ENSRNOT00000109291.1
      Conserved Domains (1) summary
      cl21457
      Location:8 → 306
      TIM; TIM-like beta/alpha barrel domains

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      68205602..68247940 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249997.5 → XP_006250059.1  N-acetylneuraminate lyase isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q119
      Conserved Domains (1) summary
      cl21457
      Location:8 → 275
      TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66H59.1 GenPept UniProtKB/Swiss-Prot:Q66H59

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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