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    MEX3A mex-3 RNA binding family member A [ Homo sapiens (human) ]

    Gene ID: 92312, updated on 7-Apr-2024

    Summary

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    Official Symbol
    MEX3Aprovided by HGNC
    Official Full Name
    mex-3 RNA binding family member Aprovided by HGNC
    Primary source
    HGNC:HGNC:33482
    See related
    Ensembl:ENSG00000254726 MIM:611007; AllianceGenome:HGNC:33482
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RKHD4; MEX-3A; RNF162
    Summary
    Enables RNA binding activity. Located in P-body and cytosol. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in endometrium (RPKM 3.0), ovary (RPKM 2.6) and 16 other tissues See more
    Orthologs
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    Genomic context

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    Location:
    1q22
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156072013..156082465, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155210478..155220930, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156041804..156052256, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1836 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 Neighboring gene RAB25, member RAS oncogene family Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr1:156045982-156046889 and GRCh37_chr1:156046890-156047796 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156051244-156052056 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156052057-156052870 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156056191-156057025 Neighboring gene Sharpr-MPRA regulatory region 15377 Neighboring gene lamin A/C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1838 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156067261-156068134 Neighboring gene VISTA enhancer hs2129 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156077037-156077778 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1420 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156087275-156087774 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156090429-156091415 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156093390-156094377 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1843 Neighboring gene Sharpr-MPRA regulatory region 4592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1845 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1846 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156096352-156097337 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:156099693-156100892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1847 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1848 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1849 Neighboring gene semaphorin 4A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1850 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:156131887-156132038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156146693-156147195

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MEX3A promotes angiogenesis in colorectal cancer via glycolysis. Lu Y, et al. Libyan J Med, 2023 Dec. PMID 37155144, Free PMC Article
    2. MEX3A Impairs DNA Mismatch Repair Signaling and Mediates Acquired Temozolomide Resistance in Glioblastoma. Gan T, et al. Cancer Res, 2022 Nov 15. PMID 36112059
    3. Mex-3 RNA binding MEX3A promotes the proliferation and migration of breast cancer cells via regulating RhoA/ROCK1/LIMK1 signaling pathway. Yan L, et al. Bioengineered, 2021 Dec. PMID 34486491, Free PMC Article
    4. Comprehensive Analysis of Prognostic Value of MEX3A and Its Relationship with Immune Infiltrates in Ovarian Cancer. Zhang P, et al. J Immunol Res, 2021. PMID 34189143, Free PMC Article
    5. MEX3A contributes to development and progression of glioma through regulating cell proliferation and cell migration and targeting CCL2. Yang C, et al. Cell Death Dis, 2021 Jan 4. PMID 33414423, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy.
      Title: Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy.
    2. MEX3A determines in vivo hepatocellular carcinoma progression and induces resistance to sorafenib in a Hippo-dependent way.
      Title: MEX3A determines in vivo hepatocellular carcinoma progression and induces resistance to sorafenib in a Hippo-dependent way.
    3. MEX3A induces the development of thyroid cancer via targeting CREB1.
      Title: MEX3A induces the development of thyroid cancer via targeting CREB1.
    4. The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.
      Title: The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.
    5. Mex3a promotes oncogenesis through the RAP1/MAPK signaling pathway in colorectal cancer and is inhibited by hsa-miR-6887-3p.
      Title: Mex3a promotes oncogenesis through the RAP1/MAPK signaling pathway in colorectal cancer and is inhibited by hsa-miR-6887-3p.
    6. MEX3A promotes angiogenesis in colorectal cancer via glycolysis.
      Title: MEX3A promotes angiogenesis in colorectal cancer via glycolysis.
    7. MEX3A Mediates p53 Degradation to Suppress Ferroptosis and Facilitate Ovarian Cancer Tumorigenesis.
      Title: MEX3A Mediates p53 Degradation to Suppress Ferroptosis and Facilitate Ovarian Cancer Tumorigenesis.
    8. RNA-Binding Protein MEX3A Interacting with DVL3 Stabilizes Wnt/beta-Catenin Signaling in Endometrial Carcinoma.
      Title: RNA-Binding Protein MEX3A Interacting with DVL3 Stabilizes Wnt/β-Catenin Signaling in Endometrial Carcinoma.
    9. MEX3A Impairs DNA Mismatch Repair Signaling and Mediates Acquired Temozolomide Resistance in Glioblastoma.
      Title: MEX3A Impairs DNA Mismatch Repair Signaling and Mediates Acquired Temozolomide Resistance in Glioblastoma.
    10. SMYD2 epigenetically activates MEX3A and suppresses CDX2 in colorectal cancer cells to augment cancer growth.
      Title: SMYD2 epigenetically activates MEX3A and suppresses CDX2 in colorectal cancer cells to augment cancer growth.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein MEX3A
    Names
    RING finger and KH domain-containing protein 4
    ring finger and KH domain containing 4
    ring finger and KH domain containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001093725.2 → NP_001087194.1  RNA-binding protein MEX3A

      See identical proteins and their annotated locations for NP_001087194.1

      Status: VALIDATED

      Source sequence(s)
      AK125482, AL355388, AY950677, CX873216
      Consensus CDS
      CCDS53377.1
      UniProtKB/Swiss-Prot
      A1L020
      Related
      ENSP00000432845.1, ENST00000532414.3
      Conserved Domains (3) summary
      cd16518
      Location:469 → 509
      RING-HC_MEX3; RING finger, HC subclass, found in RNA-binding proteins of the evolutionarily-conserved MEX-3 family
      cd22423
      Location:132 → 204
      KH-I_MEX3_rpt1; first type I K homology (KH) RNA-binding domain found in the family of MEX-3 RNA-binding proteins
      cd22424
      Location:221 → 292
      KH-I_MEX3_rpt2; second type I K homology (KH) RNA-binding domain found in the family of MEX-3 RNA-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      156072013..156082465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      155210478..155220930 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1L020.1 GenPept UniProtKB/Swiss-Prot:A1L020

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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