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    Gpr12 G-protein coupled receptor 12 [ Mus musculus (house mouse) ]

    Gene ID: 14738, updated on 8-May-2024

    Summary

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    Official Symbol
    Gpr12provided by MGI
    Official Full Name
    G-protein coupled receptor 12provided by MGI
    Primary source
    MGI:MGI:101909
    See related
    Ensembl:ENSMUSG00000041468 AllianceGenome:MGI:101909
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gpcr01; Gpcr12; Gpcr20; Gpcr21
    Summary
    Enables phosphatidylcholine binding activity. Acts upstream of or within G protein-coupled receptor signaling pathway and cellular calcium ion homeostasis. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in central nervous system; gut; and liver. Used to study obesity. Orthologous to human GPR12 (G protein-coupled receptor 12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E18 (RPKM 6.4), cortex adult (RPKM 4.0) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 G3; 5 85.23 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (146518960..146523274, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (146582150..146586465, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 3415 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_14847 Neighboring gene predicted gene, 34333 Neighboring gene STARR-seq mESC enhancer starr_14848 Neighboring gene STARR-positive B cell enhancer ABC_E11731 Neighboring gene STARR-positive B cell enhancer ABC_E2772 Neighboring gene STARR-positive B cell enhancer ABC_E6399 Neighboring gene STARR-positive B cell enhancer ABC_E6400 Neighboring gene predicted gene, 34700

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A Thalamic Orphan Receptor Drives Variability in Short-Term Memory. Hsiao K, et al. Cell, 2020 Oct 15. PMID 32997977, Free PMC Article
    2. Metabolic parameters and emotionality are little affected in G-protein coupled receptor 12 (Gpr12) mutant mice. Frank E, et al. PLoS One, 2012. PMID 22879962, Free PMC Article
    3. G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice. Bjursell M, et al. Biochem Biophys Res Commun, 2006 Sep 22. PMID 16887097
    4. Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development. Ignatov A, et al. J Neurosci, 2003 Feb 1. PMID 12574419, Free PMC Article
    5. Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth. Tanaka S, et al. J Biol Chem, 2007 Apr 6. PMID 17284443

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Thalamic Orphan Receptor Drives Variability in Short-Term Memory.
      Title: A Thalamic Orphan Receptor Drives Variability in Short-Term Memory.
    2. Studying metabolic and emotionality parameters in Gpr12 mutant mice did not reveal a major phenotypic impact of the gene mutation.
      Title: Metabolic parameters and emotionality are little affected in G-protein coupled receptor 12 (Gpr12) mutant mice.
    3. the cAMP levels required for maintaining meiotic arrest in mouse and rat oocytes are dependent on the expression of Gpr3 and/or Gpr12
      Title: The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes.
    4. GPCR12 is considered important for the energy balance since GPCR12 KO mice develop obesity and have lower energy expenditure.
      Title: G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylcholine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular calcium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010941.2 → NP_001010941.1  G-protein coupled receptor 12 isoform a

      See identical proteins and their annotated locations for NP_001010941.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1-5 all encode the same isoform (a).
      Source sequence(s)
      AK140298, AW125657, BB653482, BC055746
      Consensus CDS
      CCDS19871.1
      UniProtKB/Swiss-Prot
      P35412
      Related
      ENSMUSP00000038245.7, ENSMUST00000036211.8
      Conserved Domains (1) summary
      cd15961
      Location:45 → 312
      7tmA_GPR12; G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001359055.1 → NP_001345984.1  G-protein coupled receptor 12 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (a). Variants 1-5 all encode the same isoform (a).
      Source sequence(s)
      AC127589
      Consensus CDS
      CCDS19871.1
      UniProtKB/Swiss-Prot
      P35412
      Conserved Domains (1) summary
      cd15961
      Location:45 → 312
      7tmA_GPR12; G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_001359056.1 → NP_001345985.1  G-protein coupled receptor 12 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1-5 all encode the same isoform (a).
      Source sequence(s)
      AC127589
      Consensus CDS
      CCDS19871.1
      UniProtKB/Swiss-Prot
      P35412
      Conserved Domains (1) summary
      cd15961
      Location:45 → 312
      7tmA_GPR12; G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. NM_001359057.1 → NP_001345986.1  G-protein coupled receptor 12 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. Variants 1-5 all encode the same isoform (a).
      Source sequence(s)
      AC127589
      Consensus CDS
      CCDS19871.1
      UniProtKB/Swiss-Prot
      P35412
      Related
      ENSMUSP00000142889.2, ENSMUST00000197431.2
      Conserved Domains (1) summary
      cd15961
      Location:45 → 312
      7tmA_GPR12; G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors

    5. NM_001359058.1 → NP_001345987.1  G-protein coupled receptor 12 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC127589, BY779961
      Conserved Domains (2) summary
      cd14964
      Location:1 → 16
      7tm_GPCRs; TM helix 4 [structural motif]
      cl28897
      Location:1 → 153
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    6. NM_008151.3 → NP_032177.1  G-protein coupled receptor 12 isoform a

      See identical proteins and their annotated locations for NP_032177.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks the 5' exon but has an alternate 5' segment, as compared to variant 3. Variants 1-5 all encode the same isoform (a).
      Source sequence(s)
      AW125657, BC055746
      Consensus CDS
      CCDS19871.1
      UniProtKB/Swiss-Prot
      P35412
      Related
      ENSMUST00000196096.2
      Conserved Domains (1) summary
      cd15961
      Location:45 → 312
      7tmA_GPR12; G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      146518960..146523274 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254133.2 → XP_030109993.1  G-protein coupled receptor 12 isoform X1

      UniProtKB/Swiss-Prot
      P35412
      Conserved Domains (1) summary
      cd15961
      Location:45 → 312
      7tmA_GPR12; G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_030254134.2 → XP_030109994.1  G-protein coupled receptor 12 isoform X2

      Conserved Domains (2) summary
      cd14964
      Location:1 → 16
      7tm_GPCRs; TM helix 4 [structural motif]
      cl28897
      Location:1 → 153
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35412.1 GenPept UniProtKB/Swiss-Prot:P35412

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