cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cyp26c1provided by ZNC
Official Full Name: cytochrome P450, family 26, subfamily C, polypeptide 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-050714-2
See related: Ensembl:ENSDARG00000056029 AllianceGenome:ZFIN:ZDB-GENE-050714-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cyp26d1; cyp26b1l
Summary: Predicted to enable monooxygenase activity. Acts upstream of or within several processes, including circulatory system development; retinoic acid metabolic process; and rhombomere 4 morphogenesis. Is expressed in several structures, including brain; eye; hindbrain neural keel; optic cup; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in focal dermal hypoplasia. Orthologous to human CYP26C1 (cytochrome P450 family 26 subfamily C member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 17

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (19522856..19535316, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (19503020..19515480, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In zebrafish, two Cyp26 enzymes, Cyp26a1 and Cyp26c1, are expressed in the anterior lateral plate mesoderm (ALPM) and predominantly overlap with vascular progenitors (VPs).
Title: Cyp26 enzymes are required to balance the cardiac and vascular lineages within the anterior lateral plate mesoderm.
Zebrafish Cyp26D1 is involved in Retinoic acid metabolism.
Title: A novel cytochrome P450, zebrafish Cyp26D1, is involved in metabolism of all-trans retinoic acid.
In zebrafish morphogenesis, cyp26d1 is first expressed in sphere stage.
Title: Molecular cloning and expression of a novel CYP26 gene (cyp26d1) during zebrafish early development.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within atrial cardiac muscle cell development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hindbrain development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within outflow tract morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pectoral fin development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pectoral fin development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinoic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within rhombomere 4 morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vasculature development	IGI Inferred from Genetic Interaction more info	PubMed

General protein information

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Preferred Names: cytochrome P450 26C1

Names: retinoic acid catabolizing enzyme

NP_001025122.2

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.