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    Cep44 centrosomal protein 44 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290722, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cep44provided by RGD
    Official Full Name
    centrosomal protein 44provided by RGD
    Primary source
    RGD:1308517
    See related
    Ensembl:ENSRNOG00000010566 AllianceGenome:RGD:1308517
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308517
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in centriole replication and centriole-centriole cohesion. Predicted to be located in centriole. Predicted to be active in centrosome and spindle pole. Orthologous to human CEP44 (centrosomal protein 44). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 45.4), Thymus (RPKM 43.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    16p11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (38722259..38741603)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (33711548..33733226)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (37177379..37199043)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene F-box protein 8 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ribosomal oxygenase 2, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article
    2. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC125247

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centriole replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in centriole-centriole cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centriole-centriole cohesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centrosome cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 44 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037181.1 → NP_001032258.1  centrosomal protein of 44 kDa

      See identical proteins and their annotated locations for NP_001032258.1

      Status: PROVISIONAL

      Source sequence(s)
      BC107470
      UniProtKB/Swiss-Prot
      Q3B7T8
      UniProtKB/TrEMBL
      A6KIX5
      Related
      ENSRNOP00000014083.5, ENSRNOT00000014083.6
      Conserved Domains (1) summary
      pfam15007
      Location:5 → 128
      CEP44; Centrosomal spindle body, CEP44

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      38722259..38741603
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253089.4 → XP_006253151.1  centrosomal protein of 44 kDa isoform X3

      Conserved Domains (1) summary
      pfam15007
      Location:5 → 128
      CEP44; Centrosomal spindle body, CEP44

    2. XM_006253090.5 → XP_006253152.1  centrosomal protein of 44 kDa isoform X6

      Conserved Domains (1) summary
      pfam15007
      Location:5 → 79
      CEP44; Centrosomal spindle body, CEP44

    3. XM_039094372.2 → XP_038950300.1  centrosomal protein of 44 kDa isoform X7

      UniProtKB/TrEMBL
      A6KIX6
      Conserved Domains (1) summary
      pfam15007
      Location:5 → 128
      CEP44; Centrosomal spindle body, CEP44

    4. XM_063275226.1 → XP_063131296.1  centrosomal protein of 44 kDa isoform X4

    5. XM_006253087.5 → XP_006253149.1  centrosomal protein of 44 kDa isoform X1

      See identical proteins and their annotated locations for XP_006253149.1

      UniProtKB/Swiss-Prot
      Q3B7T8
      UniProtKB/TrEMBL
      A6KIX5
      Conserved Domains (1) summary
      pfam15007
      Location:5 → 128
      CEP44; Centrosomal spindle body, CEP44

    6. XM_063275225.1 → XP_063131295.1  centrosomal protein of 44 kDa isoform X3

    7. XM_063275228.1 → XP_063131298.1  centrosomal protein of 44 kDa isoform X6

    8. XM_008771223.3 → XP_008769445.1  centrosomal protein of 44 kDa isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZZU2
      Related
      ENSRNOP00000083699.1
      Conserved Domains (1) summary
      pfam15007
      Location:14 → 111
      CEP44; Centrosomal spindle body, CEP44

    9. XM_063275227.1 → XP_063131297.1  centrosomal protein of 44 kDa isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3B7T8.1 GenPept UniProtKB/Swiss-Prot:Q3B7T8

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