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    Prelp proline and arginine rich end leucine rich repeat protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84400, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Prelpprovided by RGD
    Official Full Name
    proline and arginine rich end leucine rich repeat proteinprovided by RGD
    Primary source
    RGD:620226
    See related
    Ensembl:ENSRNOG00000003120 AllianceGenome:RGD:620226
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables heparin binding activity. Predicted to act upstream of or within cell aging. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space. Orthologous to human PRELP (proline and arginine rich end leucine rich repeat protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 274.0), Uterus (RPKM 96.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    13q13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (47920480..47943547, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (45368407..45391480, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (50749526..50773934, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene ATPase plasma membrane Ca2+ transporting 4 Neighboring gene uncharacterized LOC134481498 Neighboring gene uncharacterized LOC102557118 Neighboring gene opticin Neighboring gene uncharacterized LOC134481559 Neighboring gene uncharacterized LOC134481558 Neighboring gene uncharacterized LOC120096251 Neighboring gene fibromodulin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The leucine-rich repeat protein PRELP binds fibroblast cell-surface proteoglycans and enhances focal adhesion formation. Bengtsson E, et al. Biochem J, 2016 May 1. PMID 26920026
    2. The amino-terminal part of PRELP binds to heparin and heparan sulfate. Bengtsson E, et al. J Biol Chem, 2000 Dec 29. PMID 11007795
    3. Spatial and temporal regulation of gene expression in the mammalian growth plate. Lui JC, et al. Bone, 2010 May. PMID 20096814, Free PMC Article
    4. Female-specific hypertension loci on rat chromosome 13. Hoffman MJ, et al. Hypertension, 2013 Sep. PMID 23817491, Free PMC Article
    5. Functional genetic screen for genes involved in senescence: role of Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in senescence and cell survival. Tarunina M, et al. Mol Cell Biol, 2004 Dec. PMID 15572682, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings provide support for a role of the N-terminal region of PRELP as an important regulator of cell adhesion and behaviour, which may be of importance in pathological conditions.
      Title: The leucine-rich repeat protein PRELP binds fibroblast cell-surface proteoglycans and enhances focal adhesion formation.
    2. Prelp were present exclusively in the proliferative zone of in growth plate cartilage of 1-week-old rats.
      Title: Spatial and temporal regulation of gene expression in the mammalian growth plate.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular senescence ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    prolargin
    Names
    proline arginine-rich end leucine-rich repeat protein-like
    proline-arginine-rich end leucine-rich repeat protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053385.1 → NP_445837.1  prolargin precursor

      See identical proteins and their annotated locations for NP_445837.1

      Status: PROVISIONAL

      Source sequence(s)
      AF163569
      UniProtKB/Swiss-Prot
      Q9EQP5
      Related
      ENSRNOP00000004241.2, ENSRNOT00000004241.5
      Conserved Domains (3) summary
      COG4886
      Location:85 → 321
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:99 → 122
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01462
      Location:67 → 97
      LRRNT; Leucine rich repeat N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      47920480..47943547 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249891.5 → XP_006249953.1  prolargin isoform X1

      See identical proteins and their annotated locations for XP_006249953.1

      UniProtKB/Swiss-Prot
      Q9EQP5
      Conserved Domains (3) summary
      COG4886
      Location:85 → 321
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:99 → 122
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01462
      Location:67 → 97
      LRRNT; Leucine rich repeat N-terminal domain

    2. XM_008769572.3 → XP_008767794.1  prolargin isoform X1

      See identical proteins and their annotated locations for XP_008767794.1

      UniProtKB/Swiss-Prot
      Q9EQP5
      Conserved Domains (3) summary
      COG4886
      Location:85 → 321
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:99 → 122
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01462
      Location:67 → 97
      LRRNT; Leucine rich repeat N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EQP5.1 GenPept UniProtKB/Swiss-Prot:Q9EQP5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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