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    NUCB2 nucleobindin 2 [ Homo sapiens (human) ]

    Gene ID: 4925, updated on 5-May-2024

    Summary

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    Official Symbol
    NUCB2provided by HGNC
    Official Full Name
    nucleobindin 2provided by HGNC
    Primary source
    HGNC:HGNC:8044
    See related
    Ensembl:ENSG00000070081 MIM:608020; AllianceGenome:HGNC:8044
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NEFA; HEL-S-109
    Summary
    This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011]
    Expression
    Broad expression in bone marrow (RPKM 51.4), salivary gland (RPKM 41.2) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    11p15.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (17276739..17349980)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (17374367..17447613)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (17298286..17353758)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:17216823-17217324 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:17223457-17223958 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:17228800-17229323 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:17229324-17229846 Neighboring gene ribosomal protein L29 pseudogene 21 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4486 Neighboring gene ribosomal protein S2 pseudogene 40 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4487 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3183 Neighboring gene uncharacterized LOC124902640 Neighboring gene uncharacterized LOC105376576 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:17373285-17373886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:17373887-17374488 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4488 Neighboring gene MPRA-validated peak1220 silencer Neighboring gene natural killer cell cytotoxicity receptor 3 ligand 1 Neighboring gene NANOG hESC enhancer GRCh37_chr11:17397887-17398425 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:17399732-17400931 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:17408081-17408734 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:17408735-17409388 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3185 Neighboring gene potassium inwardly rectifying channel subfamily J member 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. NUCB2/Nesfatin-1 drives breast cancer metastasis through the up-regulation of cholesterol synthesis via the mTORC1 pathway. Ning S, et al. J Transl Med, 2023 Jun 5. PMID 37277807, Free PMC Article
    2. Nesfatin-1 suppresses autophagy of chondrocytes in osteoarthritis via remodeling of cytoskeleton and inhibiting RhoA/ROCK signal pathway. Jiang L, et al. J Orthop Surg Res, 2023 Mar 2. PMID 36859270, Free PMC Article
    3. Nesfatin-1 in Human Milk and Its Association with Infant Anthropometry. Honoré KD, et al. Nutrients, 2022 Dec 30. PMID 36615833, Free PMC Article
    4. Nesfatin-1 Stimulates CCL2-dependent Monocyte Migration And M1 Macrophage Polarization: Implications For Rheumatoid Arthritis Therapy. Chang JW, et al. Int J Biol Sci, 2023. PMID 36594093, Free PMC Article
    5. Does one plus one always equal two? Structural differences between nesfatin-1, -2, and nesfatin-1/2. Lenda R, et al. Cell Commun Signal, 2022 Oct 24. PMID 36280843, Free PMC Article

    See all (180) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of Nucleobindin-2 in the Clinical Pathogenesis and Treatment Resistance of Glioblastoma.
      Title: Role of Nucleobindin-2 in the Clinical Pathogenesis and Treatment Resistance of Glioblastoma.
    2. High plasma nesfatin-1 level in Chinese adolescents with depression.
      Title: High plasma nesfatin-1 level in Chinese adolescents with depression.
    3. NUCB2/nesfatin-1 in the acute stress response of obese women with high and low anxiety.
      Title: NUCB2/nesfatin-1 in the acute stress response of obese women with high and low anxiety.
    4. Nucleobindin-2 Mediates Transforming Growth Factor-beta1-Driven Phenotypes in Zinc Finger E-Box Binding Homeobox 1-High Uterine Carcinosarcoma.
      Title: Nucleobindin-2 Mediates Transforming Growth Factor-β1-Driven Phenotypes in Zinc Finger E-Box Binding Homeobox 1-High Uterine Carcinosarcoma.
    5. NUCB2/Nesfatin-1 drives breast cancer metastasis through the up-regulation of cholesterol synthesis via the mTORC1 pathway.
      Title: NUCB2/Nesfatin-1 drives breast cancer metastasis through the up-regulation of cholesterol synthesis via the mTORC1 pathway.
    6. Nesfatin-1 suppresses autophagy of chondrocytes in osteoarthritis via remodeling of cytoskeleton and inhibiting RhoA/ROCK signal pathway.
      Title: Nesfatin-1 suppresses autophagy of chondrocytes in osteoarthritis via remodeling of cytoskeleton and inhibiting RhoA/ROCK signal pathway.
    7. Does NUCB2/Nesfatin-1 Influence Eating Behaviors in Obese Patients with Binge Eating Disorder? Toward a Neurobiological Pathway.
      Title: Does NUCB2/Nesfatin-1 Influence Eating Behaviors in Obese Patients with Binge Eating Disorder? Toward a Neurobiological Pathway.
    8. Nesfatin-1 in Human Milk and Its Association with Infant Anthropometry.
      Title: Nesfatin-1 in Human Milk and Its Association with Infant Anthropometry.
    9. Nesfatin-1 Stimulates CCL2-dependent Monocyte Migration And M1 Macrophage Polarization: Implications For Rheumatoid Arthritis Therapy.
      Title: Nesfatin-1 Stimulates CCL2-dependent Monocyte Migration And M1 Macrophage Polarization: Implications For Rheumatoid Arthritis Therapy.
    10. Does one plus one always equal two? Structural differences between nesfatin-1, -2, and nesfatin-1/2.
      Title: Does one plus one always equal two? Structural differences between nesfatin-1, -2, and nesfatin-1/2.
    Submit: New GeneRIF Correction See all GeneRIFs (139)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ39156

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G-protein alpha-subunit binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in sequestering of metal ion EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in extracellular space HDA PubMed 
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nucleobindin-2
    Names
    DNA-binding protein NEFA
    epididymis secretory protein Li 109
    gastric cancer antigen Zg4
    nesfatin 1
    novel DNA binding/EF-hand/leucine zipper protein
    nucleobinding 2
    prepronesfatin

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330227.3 → NP_001317156.1  nucleobindin-2 isoform 2 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      UniProtKB/TrEMBL
      J3KQU0, Q2L696
      Conserved Domains (1) summary
      PRK12704
      Location:258 → 369
      PRK12704; phosphodiesterase; Provisional

    2. NM_001352661.2 → NP_001339590.1  nucleobindin-2 isoform 3 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      Conserved Domains (2) summary
      PRK12704
      Location:344 → 401
      PRK12704; phosphodiesterase; Provisional
      pfam13499
      Location:248 → 323
      EF-hand_7; EF-hand domain pair

    3. NM_001352662.2 → NP_001339591.1  nucleobindin-2 isoform 4 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      Conserved Domains (1) summary
      cl25602
      Location:259 → 370
      DUF3552; Domain of unknown function (DUF3552)

    4. NM_001352663.2 → NP_001339592.1  nucleobindin-2 isoform 3 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      Conserved Domains (2) summary
      PRK12704
      Location:344 → 401
      PRK12704; phosphodiesterase; Provisional
      pfam13499
      Location:248 → 323
      EF-hand_7; EF-hand domain pair

    5. NM_001352664.2 → NP_001339593.1  nucleobindin-2 isoform 1 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      Consensus CDS
      CCDS41623.1
      UniProtKB/Swiss-Prot
      A8K642, D3DQX5, P80303, Q8NFT5, V9HW75
      Conserved Domains (2) summary
      PRK12704
      Location:343 → 400
      PRK12704; phosphodiesterase; Provisional
      pfam13499
      Location:247 → 322
      EF-hand_7; EF-hand domain pair

    6. NM_001352665.2 → NP_001339594.1  nucleobindin-2 isoform 2 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      UniProtKB/TrEMBL
      J3KQU0, Q2L696
      Conserved Domains (1) summary
      PRK12704
      Location:258 → 369
      PRK12704; phosphodiesterase; Provisional

    7. NM_001352666.2 → NP_001339595.1  nucleobindin-2 isoform 2 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      UniProtKB/TrEMBL
      J3KQU0, Q2L696
      Conserved Domains (1) summary
      PRK12704
      Location:258 → 369
      PRK12704; phosphodiesterase; Provisional

    8. NM_001352667.2 → NP_001339596.1  nucleobindin-2 isoform 2 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      UniProtKB/TrEMBL
      J3KQU0, Q2L696
      Conserved Domains (1) summary
      PRK12704
      Location:258 → 369
      PRK12704; phosphodiesterase; Provisional

    9. NM_001352668.2 → NP_001339597.1  nucleobindin-2 isoform 1 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      Consensus CDS
      CCDS41623.1
      UniProtKB/Swiss-Prot
      A8K642, D3DQX5, P80303, Q8NFT5, V9HW75
      Conserved Domains (2) summary
      PRK12704
      Location:343 → 400
      PRK12704; phosphodiesterase; Provisional
      pfam13499
      Location:247 → 322
      EF-hand_7; EF-hand domain pair

    10. NM_001352669.2 → NP_001339598.1  nucleobindin-2 isoform 1 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      Consensus CDS
      CCDS41623.1
      UniProtKB/Swiss-Prot
      A8K642, D3DQX5, P80303, Q8NFT5, V9HW75
      Conserved Domains (2) summary
      PRK12704
      Location:343 → 400
      PRK12704; phosphodiesterase; Provisional
      pfam13499
      Location:247 → 322
      EF-hand_7; EF-hand domain pair

    11. NM_001352670.2 → NP_001339599.1  nucleobindin-2 isoform 1 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      Consensus CDS
      CCDS41623.1
      UniProtKB/Swiss-Prot
      A8K642, D3DQX5, P80303, Q8NFT5, V9HW75
      Conserved Domains (2) summary
      PRK12704
      Location:343 → 400
      PRK12704; phosphodiesterase; Provisional
      pfam13499
      Location:247 → 322
      EF-hand_7; EF-hand domain pair

    12. NM_001352671.2 → NP_001339600.1  nucleobindin-2 isoform 2 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      UniProtKB/TrEMBL
      J3KQU0, Q2L696
      Conserved Domains (1) summary
      PRK12704
      Location:258 → 369
      PRK12704; phosphodiesterase; Provisional

    13. NM_001352672.2 → NP_001339601.1  nucleobindin-2 isoform 1 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      Consensus CDS
      CCDS41623.1
      UniProtKB/Swiss-Prot
      A8K642, D3DQX5, P80303, Q8NFT5, V9HW75
      Conserved Domains (2) summary
      PRK12704
      Location:343 → 400
      PRK12704; phosphodiesterase; Provisional
      pfam13499
      Location:247 → 322
      EF-hand_7; EF-hand domain pair

    14. NM_005013.4 → NP_005004.1  nucleobindin-2 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_005004.1

      Status: VALIDATED

      Source sequence(s)
      AC107956, KF455328
      Consensus CDS
      CCDS41623.1
      UniProtKB/Swiss-Prot
      A8K642, D3DQX5, P80303, Q8NFT5, V9HW75
      Related
      ENSP00000436455.1, ENST00000529010.6
      Conserved Domains (2) summary
      PRK12704
      Location:343 → 400
      PRK12704; phosphodiesterase; Provisional
      pfam13499
      Location:247 → 322
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      17276739..17349980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448553.2 → XP_024304321.1  nucleobindin-2 isoform X5

      Conserved Domains (1) summary
      cl25602
      Location:258 → 369
      DUF3552; Domain of unknown function (DUF3552)

    2. XM_024448538.2 → XP_024304306.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      PRK12704
      Location:343 → 400
      PRK12704; phosphodiesterase; Provisional
      pfam13499
      Location:247 → 322
      EF-hand_7; EF-hand domain pair

    3. XM_024448540.2 → XP_024304308.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      PRK12704
      Location:343 → 400
      PRK12704; phosphodiesterase; Provisional
      pfam13499
      Location:247 → 322
      EF-hand_7; EF-hand domain pair

    4. XM_024448542.2 → XP_024304310.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      PRK12704
      Location:343 → 400
      PRK12704; phosphodiesterase; Provisional
      pfam13499
      Location:247 → 322
      EF-hand_7; EF-hand domain pair

    5. XM_024448535.2 → XP_024304303.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      PRK12704
      Location:343 → 400
      PRK12704; phosphodiesterase; Provisional
      pfam13499
      Location:247 → 322
      EF-hand_7; EF-hand domain pair

    6. XM_047426990.1 → XP_047282946.1  nucleobindin-2 isoform X5

    7. XM_024448527.2 → XP_024304295.1  nucleobindin-2 isoform X1

      Conserved Domains (2) summary
      pfam13499
      Location:248 → 324
      EF-hand_7; EF-hand domain pair
      cl25632
      Location:306 → 399
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family

    8. XM_024448532.2 → XP_024304300.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      PRK12704
      Location:343 → 400
      PRK12704; phosphodiesterase; Provisional
      pfam13499
      Location:247 → 322
      EF-hand_7; EF-hand domain pair

    9. XM_024448550.2 → XP_024304318.1  nucleobindin-2 isoform X5

      Conserved Domains (1) summary
      cl25602
      Location:258 → 369
      DUF3552; Domain of unknown function (DUF3552)

    10. XM_024448533.2 → XP_024304301.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      PRK12704
      Location:343 → 400
      PRK12704; phosphodiesterase; Provisional
      pfam13499
      Location:247 → 322
      EF-hand_7; EF-hand domain pair

    11. XM_024448551.2 → XP_024304319.1  nucleobindin-2 isoform X5

      Conserved Domains (1) summary
      cl25602
      Location:258 → 369
      DUF3552; Domain of unknown function (DUF3552)

    12. XM_024448531.2 → XP_024304299.1  nucleobindin-2 isoform X2

      Related
      ENSP00000320168.6, ENST00000323688.10
      Conserved Domains (2) summary
      PRK12704
      Location:343 → 400
      PRK12704; phosphodiesterase; Provisional
      pfam13499
      Location:247 → 322
      EF-hand_7; EF-hand domain pair

    13. XM_024448549.2 → XP_024304317.1  nucleobindin-2 isoform X5

      Conserved Domains (1) summary
      cl25602
      Location:258 → 369
      DUF3552; Domain of unknown function (DUF3552)

    14. XM_024448547.2 → XP_024304315.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      PRK12704
      Location:343 → 400
      PRK12704; phosphodiesterase; Provisional
      pfam13499
      Location:247 → 322
      EF-hand_7; EF-hand domain pair

    15. XM_047426988.1 → XP_047282944.1  nucleobindin-2 isoform X4

      UniProtKB/Swiss-Prot
      A8K642, D3DQX5, P80303, Q8NFT5, V9HW75

    16. XM_017017812.3 → XP_016873301.1  nucleobindin-2 isoform X4

      UniProtKB/Swiss-Prot
      A8K642, D3DQX5, P80303, Q8NFT5, V9HW75
      Conserved Domains (2) summary
      PRK12704
      Location:343 → 400
      PRK12704; phosphodiesterase; Provisional
      pfam13499
      Location:247 → 322
      EF-hand_7; EF-hand domain pair

    17. XM_047426992.1 → XP_047282948.1  nucleobindin-2 isoform X6

      UniProtKB/TrEMBL
      J3KQU0, Q2L696

    18. XM_017017814.2 → XP_016873303.1  nucleobindin-2 isoform X4

      UniProtKB/Swiss-Prot
      A8K642, D3DQX5, P80303, Q8NFT5, V9HW75
      Conserved Domains (2) summary
      PRK12704
      Location:343 → 400
      PRK12704; phosphodiesterase; Provisional
      pfam13499
      Location:247 → 322
      EF-hand_7; EF-hand domain pair

    19. XM_017017828.2 → XP_016873317.1  nucleobindin-2 isoform X6

      UniProtKB/TrEMBL
      J3KQU0, Q2L696
      Conserved Domains (1) summary
      PRK12704
      Location:258 → 369
      PRK12704; phosphodiesterase; Provisional

    20. XM_047426986.1 → XP_047282942.1  nucleobindin-2 isoform X4

      UniProtKB/Swiss-Prot
      A8K642, D3DQX5, P80303, Q8NFT5, V9HW75

    21. XM_017017826.2 → XP_016873315.1  nucleobindin-2 isoform X6

      UniProtKB/TrEMBL
      J3KQU0, Q2L696
      Conserved Domains (1) summary
      PRK12704
      Location:258 → 369
      PRK12704; phosphodiesterase; Provisional

    22. XM_017017818.3 → XP_016873307.1  nucleobindin-2 isoform X4

      UniProtKB/Swiss-Prot
      A8K642, D3DQX5, P80303, Q8NFT5, V9HW75
      Conserved Domains (2) summary
      PRK12704
      Location:343 → 400
      PRK12704; phosphodiesterase; Provisional
      pfam13499
      Location:247 → 322
      EF-hand_7; EF-hand domain pair

    23. XM_047426983.1 → XP_047282939.1  nucleobindin-2 isoform X2

    24. XM_024448545.2 → XP_024304313.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      PRK12704
      Location:343 → 400
      PRK12704; phosphodiesterase; Provisional
      pfam13499
      Location:247 → 322
      EF-hand_7; EF-hand domain pair

    25. XM_024448536.2 → XP_024304304.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      PRK12704
      Location:343 → 400
      PRK12704; phosphodiesterase; Provisional
      pfam13499
      Location:247 → 322
      EF-hand_7; EF-hand domain pair

    26. XM_024448552.2 → XP_024304320.1  nucleobindin-2 isoform X5

      Conserved Domains (1) summary
      cl25602
      Location:258 → 369
      DUF3552; Domain of unknown function (DUF3552)

    27. XM_047426982.1 → XP_047282938.1  nucleobindin-2 isoform X1

    28. XM_024448539.2 → XP_024304307.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      PRK12704
      Location:343 → 400
      PRK12704; phosphodiesterase; Provisional
      pfam13499
      Location:247 → 322
      EF-hand_7; EF-hand domain pair

    29. XM_024448541.2 → XP_024304309.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      PRK12704
      Location:343 → 400
      PRK12704; phosphodiesterase; Provisional
      pfam13499
      Location:247 → 322
      EF-hand_7; EF-hand domain pair

    30. XM_024448534.2 → XP_024304302.1  nucleobindin-2 isoform X2

      Conserved Domains (2) summary
      PRK12704
      Location:343 → 400
      PRK12704; phosphodiesterase; Provisional
      pfam13499
      Location:247 → 322
      EF-hand_7; EF-hand domain pair

    31. XM_047426989.1 → XP_047282945.1  nucleobindin-2 isoform X5

    32. XM_047426994.1 → XP_047282950.1  nucleobindin-2 isoform X6

      UniProtKB/TrEMBL
      J3KQU0, Q2L696

    33. XM_017017817.2 → XP_016873306.1  nucleobindin-2 isoform X4

      UniProtKB/Swiss-Prot
      A8K642, D3DQX5, P80303, Q8NFT5, V9HW75
      Conserved Domains (2) summary
      PRK12704
      Location:343 → 400
      PRK12704; phosphodiesterase; Provisional
      pfam13499
      Location:247 → 322
      EF-hand_7; EF-hand domain pair

    34. XM_047426985.1 → XP_047282941.1  nucleobindin-2 isoform X4

      UniProtKB/Swiss-Prot
      A8K642, D3DQX5, P80303, Q8NFT5, V9HW75

    35. XM_047426991.1 → XP_047282947.1  nucleobindin-2 isoform X6

      UniProtKB/TrEMBL
      J3KQU0, Q2L696

    36. XM_047426984.1 → XP_047282940.1  nucleobindin-2 isoform X3

    37. XM_017017813.2 → XP_016873302.1  nucleobindin-2 isoform X4

      UniProtKB/Swiss-Prot
      A8K642, D3DQX5, P80303, Q8NFT5, V9HW75
      Conserved Domains (2) summary
      PRK12704
      Location:343 → 400
      PRK12704; phosphodiesterase; Provisional
      pfam13499
      Location:247 → 322
      EF-hand_7; EF-hand domain pair

    38. XM_047426993.1 → XP_047282949.1  nucleobindin-2 isoform X6

      UniProtKB/TrEMBL
      J3KQU0, Q2L696

    39. XM_047426987.1 → XP_047282943.1  nucleobindin-2 isoform X4

      UniProtKB/Swiss-Prot
      A8K642, D3DQX5, P80303, Q8NFT5, V9HW75

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      17374367..17447613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368902.1 → XP_054224877.1  nucleobindin-2 isoform X4

      UniProtKB/Swiss-Prot
      A8K642, D3DQX5, P80303, Q8NFT5, V9HW75

    2. XM_054368898.1 → XP_054224873.1  nucleobindin-2 isoform X2

    3. XM_054368919.1 → XP_054224894.1  nucleobindin-2 isoform X6

      UniProtKB/TrEMBL
      J3KQU0, Q2L696

    4. XM_054368914.1 → XP_054224889.1  nucleobindin-2 isoform X5

    5. XM_054368892.1 → XP_054224867.1  nucleobindin-2 isoform X2

    6. XM_054368894.1 → XP_054224869.1  nucleobindin-2 isoform X2

    7. XM_054368889.1 → XP_054224864.1  nucleobindin-2 isoform X2

    8. XM_054368912.1 → XP_054224887.1  nucleobindin-2 isoform X5

    9. XM_054368885.1 → XP_054224860.1  nucleobindin-2 isoform X1

    10. XM_054368887.1 → XP_054224862.1  nucleobindin-2 isoform X2

    11. XM_054368915.1 → XP_054224890.1  nucleobindin-2 isoform X5

    12. XM_054368891.1 → XP_054224866.1  nucleobindin-2 isoform X2

    13. XM_054368916.1 → XP_054224891.1  nucleobindin-2 isoform X5

    14. XM_054368886.1 → XP_054224861.1  nucleobindin-2 isoform X2

    15. XM_054368910.1 → XP_054224885.1  nucleobindin-2 isoform X5

    16. XM_054368895.1 → XP_054224870.1  nucleobindin-2 isoform X2

    17. XM_054368903.1 → XP_054224878.1  nucleobindin-2 isoform X4

      UniProtKB/Swiss-Prot
      A8K642, D3DQX5, P80303, Q8NFT5, V9HW75

    18. XM_054368921.1 → XP_054224896.1  nucleobindin-2 isoform X6

      UniProtKB/TrEMBL
      J3KQU0, Q2L696

    19. XM_054368905.1 → XP_054224880.1  nucleobindin-2 isoform X4

      UniProtKB/Swiss-Prot
      A8K642, D3DQX5, P80303, Q8NFT5, V9HW75

    20. XM_054368917.1 → XP_054224892.1  nucleobindin-2 isoform X6

      UniProtKB/TrEMBL
      J3KQU0, Q2L696

    21. XM_054368909.1 → XP_054224884.1  nucleobindin-2 isoform X4

      UniProtKB/Swiss-Prot
      A8K642, D3DQX5, P80303, Q8NFT5, V9HW75

    22. XM_054368907.1 → XP_054224882.1  nucleobindin-2 isoform X4

      UniProtKB/Swiss-Prot
      A8K642, D3DQX5, P80303, Q8NFT5, V9HW75

    23. XM_054368899.1 → XP_054224874.1  nucleobindin-2 isoform X2

    24. XM_054368897.1 → XP_054224872.1  nucleobindin-2 isoform X2

    25. XM_054368890.1 → XP_054224865.1  nucleobindin-2 isoform X2

    26. XM_054368913.1 → XP_054224888.1  nucleobindin-2 isoform X5

    27. XM_054368893.1 → XP_054224868.1  nucleobindin-2 isoform X2

    28. XM_054368896.1 → XP_054224871.1  nucleobindin-2 isoform X2

    29. XM_054368888.1 → XP_054224863.1  nucleobindin-2 isoform X2

    30. XM_054368911.1 → XP_054224886.1  nucleobindin-2 isoform X5

    31. XM_054368922.1 → XP_054224897.1  nucleobindin-2 isoform X6

      UniProtKB/TrEMBL
      J3KQU0, Q2L696

    32. XM_054368908.1 → XP_054224883.1  nucleobindin-2 isoform X4

      UniProtKB/Swiss-Prot
      A8K642, D3DQX5, P80303, Q8NFT5, V9HW75

    33. XM_054368901.1 → XP_054224876.1  nucleobindin-2 isoform X4

      UniProtKB/Swiss-Prot
      A8K642, D3DQX5, P80303, Q8NFT5, V9HW75

    34. XM_054368918.1 → XP_054224893.1  nucleobindin-2 isoform X6

      UniProtKB/TrEMBL
      J3KQU0, Q2L696

    35. XM_054368900.1 → XP_054224875.1  nucleobindin-2 isoform X3

    36. XM_054368904.1 → XP_054224879.1  nucleobindin-2 isoform X4

      UniProtKB/Swiss-Prot
      A8K642, D3DQX5, P80303, Q8NFT5, V9HW75

    37. XM_054368920.1 → XP_054224895.1  nucleobindin-2 isoform X6

      UniProtKB/TrEMBL
      J3KQU0, Q2L696

    38. XM_054368906.1 → XP_054224881.1  nucleobindin-2 isoform X4

      UniProtKB/Swiss-Prot
      A8K642, D3DQX5, P80303, Q8NFT5, V9HW75

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_132751.1: Suppressed sequence

      Description
      NR_132751.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P80303.3 GenPept UniProtKB/Swiss-Prot:P80303

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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