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    MESK2 Misexpression suppressor of KSR 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37451, updated on 10-May-2024

    Summary

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    Official Symbol
    MESK2provided by FlyBase
    Official Full Name
    Misexpression suppressor of KSR 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0043070
    Locus tag
    Dmel_CG15669
    See related
    AllianceGenome:FB:FBgn0043070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH12032; BcDNA:LD27504; BcDNA:RH10174; CG15668; CG15669; Dmel\CG15669; l(2)01467; mesk2; Mesk2
    Summary
    Enables serine hydrolase activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm. Is expressed in adult head; wing hinge primordium; and wing pouch. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4D. Orthologous to several human genes including NDRG1 (N-myc downstream regulated 1); NDRG2 (NDRG family member 2); and NDRG3 (NDRG family member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    57E8-57E9; 2-95 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21502097..21517241)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17389602..17404746)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene TATA box-binding protein-associated factor RNA polymerase I subunit C-like Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Micro RNAs and the biological clock: a target for diseases associated with a loss of circadian regulation. Ma Q, et al. Afr Health Sci, 2020 Dec. PMID 34394254, Free PMC Article
    2. An efficient promoter trap for detection of patterned gene expression and subsequent functional analysis in Drosophila. Larsen C, et al. Proc Natl Acad Sci U S A, 2006 Nov 21. PMID 17093046, Free PMC Article
    3. A misexpression screen identifies genes that can modulate RAS1 pathway signaling in Drosophila melanogaster. Huang AM, et al. Genetics, 2000 Nov. PMID 11063696, Free PMC Article
    4. Activation of an actin signaling pathway in pre-malignant mammary epithelial cells by P-cadherin is essential for transformation. Faria L, et al. Dis Model Mech, 2023 Feb 1. PMID 36808468, Free PMC Article
    5. Regulation of Circadian Behavior by Astroglial MicroRNAs in Drosophila. You S, et al. Genetics, 2018 Mar. PMID 29487148, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine hydrolase activity HDA PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    misexpression suppressor of KSR 2
    Names
    CG15669-PA
    CG15669-PB
    CG15669-PC
    CG15669-PD
    CG15669-PE
    CG15669-PF
    CG15669-PI
    CG15669-PJ
    CG15669-PK
    MESK2-PA
    MESK2-PB
    MESK2-PC
    MESK2-PD
    MESK2-PE
    MESK2-PF
    MESK2-PI
    MESK2-PJ
    MESK2-PK

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21502097..21517241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206192.2 → NP_995914.1  misexpression suppressor of KSR 2, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995914.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GU50
      Conserved Domains (2) summary
      COG0596
      Location:57 → 334
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      cl21494
      Location:51 → 337
      Abhydrolase; alpha/beta hydrolases

    2. NM_206193.2 → NP_995915.1  misexpression suppressor of KSR 2, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995915.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGI1
      Conserved Domains (2) summary
      COG0596
      Location:40 → 317
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      cl21494
      Location:34 → 320
      Abhydrolase; alpha/beta hydrolases

    3. NM_166454.2 → NP_726076.1  misexpression suppressor of KSR 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726076.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IHG2, Q8T0V2
      Related
      FBpp0088650
      Conserved Domains (2) summary
      COG0596
      Location:139 → 416
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      cl21494
      Location:133 → 419
      Abhydrolase; alpha/beta hydrolases

    4. NM_206190.2 → NP_995912.1  misexpression suppressor of KSR 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995912.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IHG2, Q8T0V2
      Conserved Domains (2) summary
      COG0596
      Location:139 → 416
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      cl21494
      Location:133 → 419
      Abhydrolase; alpha/beta hydrolases

    5. NM_079080.3 → NP_523804.3  misexpression suppressor of KSR 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523804.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IRK7
      Related
      FBpp0088652
      Conserved Domains (2) summary
      COG0596
      Location:57 → 334
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      cl21494
      Location:51 → 337
      Abhydrolase; alpha/beta hydrolases

    6. NM_166455.2 → NP_726077.1  misexpression suppressor of KSR 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726077.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IHG2, Q9I7V7
      Related
      FBpp0088649
      Conserved Domains (1) summary
      cl21494
      Location:133 → 421
      Abhydrolase; alpha/beta hydrolases

    7. NM_166456.3 → NP_726078.1  misexpression suppressor of KSR 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726078.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IHG2, Q9I7V6
      Related
      FBpp0088651
      Conserved Domains (1) summary
      cl21494
      Location:133 → 419
      Abhydrolase; alpha/beta hydrolases

    8. NM_206194.2 → NP_995916.1  misexpression suppressor of KSR 2, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995916.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KVN1, Q8IHC7
      Conserved Domains (1) summary
      cl21494
      Location:105 → 391
      Abhydrolase; alpha/beta hydrolases

    9. NM_206191.2 → NP_995913.1  misexpression suppressor of KSR 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995913.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IHG2, Q8T0V2
      Conserved Domains (2) summary
      COG0596
      Location:139 → 416
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      cl21494
      Location:133 → 419
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KVN1 Q7KVN1
    Q8IGI1 Q8IGI1
    Q8IH54 Q8IH54
    Q8IHC7 Q8IHC7
    Q8IHG2 Q8IHG2
    Q8IHH2 Q8IHH2
    Q8IRK7 Q8IRK7
    Q8SYA3 Q8SYA3
    Q8T0V2 Q8T0V2
    Q95T14 Q95T14
    Q9GU49 Q9GU49
    Q9GU50 Q9GU50
    Q9I7V6 Q9I7V6
    Q9I7V7 Q9I7V7

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