Grpr gastrin releasing peptide receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grprprovided by MGI
Official Full Name: gastrin releasing peptide receptorprovided by MGI
Primary source: MGI:MGI:95836
See related: Ensembl:ENSMUSG00000031364 AllianceGenome:MGI:95836
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GRP-R
Summary: This gene encodes a multipass membrane protein that functions as a receptor for gastrin releasing peptide. Signalling through this receptor is important in a variety of physiological processes, including responses to itching, satiety, and fear. [provided by RefSeq, May 2015]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: X F5; X 75.63 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (162296900..162332732, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (163513904..163549736, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-6 Enhances the Activation of PI3K-AKT/mTOR-GSK-3beta by Upregulating GRPR in Hippocampal Neurons of Autistic Mice.
Title: IL-6 Enhances the Activation of PI3K-AKT/mTOR-GSK-3β by Upregulating GRPR in Hippocampal Neurons of Autistic Mice.
Grpr expression defines a population of superficial dorsal horn vertical cells that have a role in both itch and pain.
Title: Grpr expression defines a population of superficial dorsal horn vertical cells that have a role in both itch and pain.
GRPR/Extracellular Signal-Regulated Kinase and NPRA/Extracellular Signal-Regulated Kinase Signaling Pathways Play a Critical Role in Spinal Transmission of Chronic Itch.
Title: GRPR/Extracellular Signal-Regulated Kinase and NPRA/Extracellular Signal-Regulated Kinase Signaling Pathways Play a Critical Role in Spinal Transmission of Chronic Itch.
Critical role of GRP receptor-expressing neurons in the spinal transmission of imiquimod-induced psoriatic itch.
Title: Critical role of GRP receptor-expressing neurons in the spinal transmission of imiquimod-induced psoriatic itch.
GRP receptor and AMPA receptor cooperatively regulate itch-responsive neurons in the spinal dorsal horn.
Title: GRP receptor and AMPA receptor cooperatively regulate itch-responsive neurons in the spinal dorsal horn.
Spinal GRPR and NPRA Contribute to Chronic Itch in a Murine Model of Allergic Contact Dermatitis.
Title: Spinal GRPR and NPRA Contribute to Chronic Itch in a Murine Model of Allergic Contact Dermatitis.
The Neurokinin-1 Receptor is Expressed with Gastrin-Releasing Peptide Receptor in Spinal Interneurons and Modulates Itch.
Title: The Neurokinin-1 Receptor is Expressed with Gastrin-Releasing Peptide Receptor in Spinal Interneurons and Modulates Itch.
Spinal gastrin releasing peptide receptor expressing interneurons are controlled by local phasic and tonic inhibition.
Title: Spinal gastrin releasing peptide receptor expressing interneurons are controlled by local phasic and tonic inhibition.
these results suggest that the regulation of GRP-R activity or expression has an influence on adipogenesis through regulating adipogenic related genes.
Title: Involvement of Gastrin-Releasing Peptide Receptor in the Regulation of Adipocyte Differentiation in 3T3-L1 Cells.
These data suggest that GRPR expression in fibroblast-like synoviocytes (FLS)and that exogenous GRP are able to activate FLS invasion. This effect occurs at least in part through the AKT activation. Therefore, understanding of the GRP/GRPR pathway could be relevant in the development of FLS-targeted therapy for Rheumatoid arthritis .
Title: Gastrin-releasing peptide and its receptor increase arthritis fibroblast-like synoviocytes invasiveness through activating the PI3K/AKT pathway.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (5) 1 citation

General gene information

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Markers

DXMit21 (e-PCR), detects polymorphism
- UniSTS:132098

NoName (e-PCR)
- UniSTS:484880

M61000 (e-PCR)
- UniSTS:163626

Grpr (e-PCR), detects polymorphism
- UniSTS:495915

Grpr (e-PCR), detects polymorphism
- UniSTS:498771

Grpr (e-PCR), detects polymorphism
- UniSTS:143269

DXMit20 (e-PCR), detects polymorphism
- UniSTS:132090

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled peptide receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables bombesin receptor activity	TAS Traceable Author Statement more info	PubMed
enables neuropeptide binding	ISO Inferred from Sequence Orthology more info
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in learning or memory	ISO Inferred from Sequence Orthology more info
involved_in motor behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of behavioral fear response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of respiratory gaseous exchange	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in psychomotor behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to external biotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in social behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in social behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: gastrin-releasing peptide receptor

Names: GRP-preferring bombesin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.