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    GPR182 G protein-coupled receptor 182 [ Homo sapiens (human) ]

    Gene ID: 11318, updated on 3-Apr-2024

    Summary

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    Official Symbol
    GPR182provided by HGNC
    Official Full Name
    G protein-coupled receptor 182provided by HGNC
    Primary source
    HGNC:HGNC:13708
    See related
    Ensembl:ENSG00000166856 MIM:605307; AllianceGenome:HGNC:13708
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AMR; 7TMR; ADMR; AM-R; G10D; L1-R; gamrh; hrhAMR
    Summary
    Adrenomedullin is a potent vasodilator peptide that exerts major effects on cardiovascular function. This gene encodes a seven-transmembrane protein that belongs to the family 1 of G-protein coupled receptors. Studies of the rat counterpart suggest that the encoded protein may function as a receptor for adrenomedullin. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in spleen (RPKM 5.1), testis (RPKM 0.9) and 4 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    12q13.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (56994492..56998877)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (56962361..56966316)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (57388276..57392231)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene retinol dehydrogenase 16 Neighboring gene origin of replication ori6 Neighboring gene uncharacterized LOC124902945 Neighboring gene retinol dehydrogenase 16 (all-trans) pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr12.2240 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4567 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4568 Neighboring gene zinc finger and BTB domain containing 39 Neighboring gene tachykinin precursor 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:57423222-57424059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6521 Neighboring gene myosin IA Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:57440635-57441834

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Localization and distribution of adrenomedullin receptor in the human placenta: changes with gestational age. Marinoni E, et al. J Reprod Med, 2007 Sep. PMID 17939601
    2. Genomic organization and regulation of a human 7-helix transmembrane receptor which is expressed in pulmonary epithelial cells and induced in hypoxia. Hänze J, et al. Biochem Biophys Res Commun, 2002 Mar 15. PMID 11883938
    3. Role of adrenomedullin and its receptor system in renal pathophysiology. Mukoyama M, et al. Peptides, 2001 Nov. PMID 11754983
    4. Adrenomedullin: a vasoactive and natriuretic peptide with therapeutic potential. Lah JJ, et al. Heart Dis, 2000 May-Jun. PMID 11728267
    5. Expression of adrenomedullin and proadrenomedullin N-terminal 20 peptide in human and rat prostate. Jiménez N, et al. J Histochem Cytochem, 1999 Sep. PMID 10449538

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPR182 limits antitumor immunity via chemokine scavenging in mouse melanoma models.
      Title: GPR182 limits antitumor immunity via chemokine scavenging in mouse melanoma models.
    2. GPR182 is an endothelium-specific atypical chemokine receptor that maintains hematopoietic stem cell homeostasis.
      Title: GPR182 is an endothelium-specific atypical chemokine receptor that maintains hematopoietic stem cell homeostasis.
    3. Our data demonstrate that GPR182 is an endothelial subtype-specific marker for human sinusoidal EC of the liver, spleen, lymph node and bone marrow. In addition, we provide evidence for GPR182-dependent downstream signaling via ERK and SRF pathways that may be involved in regulating endothelial subtype-specific sinusoidal differentiation and sinusoidal functions such as permeability.
      Title: GPR182 is a novel marker for sinusoidal endothelial differentiation with distinct GPCR signaling activity in vitro.
    4. Gene expression of adrenomedullin receptor components are differentially regulated in the uterus during the estrous cycle.
      Title: Intermedin in rat uterus: changes in gene expression and peptide levels across the estrous cycle and its effects on uterine contraction.
    5. ADMR mediates the stimulatory effects of adrenomedullin on cancer cells and on endothelial and stellate cells within the tumor microenvironment
      Title: The ADMR receptor mediates the effects of adrenomedullin on pancreatic cancer cells and on cells of the tumor microenvironment.
    6. distribution of adrenomedullin receptor (AM-R )in the villous and extravillous trophoblast cells of the placenta and in chorion and decidua cells of the fetal membranes changed with gestational age but not with labor
      Title: Localization and distribution of adrenomedullin receptor in the human placenta: changes with gestational age.
    7. Hybridization in situ showed that ADMR mRNA expression was significantly higher in pulmonary artery walls in patients with chronic obstructive pulmonary disease.
      Title: [Study of the expression and role of adrenomedullin and adrenomedullin receptor in patients with chronic obstructive pulmonary disease].
    8. The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein (review).
      Title: The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein (review).
    9. Endogenous ADM system plays a potentially important role in the paracrine or autocrine functional control of Conn's adenomas.
      Title: Expression and function of adrenomedullin and its receptors in Conn's adenoma cells.
    10. The co-expression of Adm and its receptor in perineural fibroblasts and the expression of an Adm receptor in Schwann cells suggest autocrine and/or paracrine modes of action of Adm in peripheral nerves.
      Title: Paracrine/autocrine function of adrenomedullin in peripheral nerves of rats.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of G protein-coupled receptor 182 (GPR182) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC34399

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor 182
    Names
    adrenomedullin receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007264.4 → NP_009195.1  G-protein coupled receptor 182

      See identical proteins and their annotated locations for NP_009195.1

      Status: REVIEWED

      Source sequence(s)
      AC026120, BC034761
      Consensus CDS
      CCDS8927.1
      UniProtKB/Swiss-Prot
      O15218
      UniProtKB/TrEMBL
      Q6LAJ3
      Related
      ENSP00000300098.1, ENST00000300098.3
      Conserved Domains (1) summary
      cd14988
      Location:54 → 331
      7tmA_GPR182; G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      56994492..56998877
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428198.1 → XP_047284154.1  G-protein coupled receptor 182 isoform X1

      UniProtKB/Swiss-Prot
      O15218

    2. XM_011537827.4 → XP_011536129.1  G-protein coupled receptor 182 isoform X1

      See identical proteins and their annotated locations for XP_011536129.1

      UniProtKB/Swiss-Prot
      O15218
      UniProtKB/TrEMBL
      Q6LAJ3
      Conserved Domains (1) summary
      cd14988
      Location:54 → 331
      7tmA_GPR182; G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_011537824.4 → XP_011536126.1  G-protein coupled receptor 182 isoform X1

      See identical proteins and their annotated locations for XP_011536126.1

      UniProtKB/Swiss-Prot
      O15218
      UniProtKB/TrEMBL
      Q6LAJ3
      Conserved Domains (1) summary
      cd14988
      Location:54 → 331
      7tmA_GPR182; G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. XM_011537825.4 → XP_011536127.1  G-protein coupled receptor 182 isoform X1

      See identical proteins and their annotated locations for XP_011536127.1

      UniProtKB/Swiss-Prot
      O15218
      UniProtKB/TrEMBL
      Q6LAJ3
      Conserved Domains (1) summary
      cd14988
      Location:54 → 331
      7tmA_GPR182; G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      56962361..56966316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370942.1 → XP_054226917.1  G-protein coupled receptor 182 isoform X1

      UniProtKB/Swiss-Prot
      O15218

    2. XM_054370943.1 → XP_054226918.1  G-protein coupled receptor 182 isoform X1

      UniProtKB/Swiss-Prot
      O15218

    3. XM_054370944.1 → XP_054226919.1  G-protein coupled receptor 182 isoform X1

      UniProtKB/Swiss-Prot
      O15218
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15218.1 GenPept UniProtKB/Swiss-Prot:O15218

    Gene LinkOut

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