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    Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500261, updated on 16-Apr-2024

    Summary

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    Official Symbol
    Magi1provided by RGD
    Official Full Name
    membrane associated guanylate kinase, WW and PDZ domain containing 1provided by RGD
    Primary source
    RGD:1586025
    See related
    Ensembl:ENSRNOG00000022060 AllianceGenome:RGD:1586025
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    BAP-1; Baiap1; MAGI-1
    Summary
    Predicted to enable alpha-actinin binding activity. Predicted to be involved in positive regulation of cell-cell adhesion and signal transduction. Predicted to be located in several cellular components, including adherens junction; nuclear lumen; and plasma membrane. Predicted to be active in cell-cell junction and cytoplasm. Orthologous to human MAGI1 (membrane associated guanylate kinase, WW and PDZ domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 115.8), Lung (RPKM 114.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    4q34
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (127762590..128368228, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (126205663..126811354, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (125684816..126300013, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ribosomal protein lateral stalk subunit P0, pseudogene 15 Neighboring gene uncharacterized LOC134486617 Neighboring gene transfer RNA threonine (anticodon AGU) 30 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene GABA type A receptor-associated protein, pseudogene 3 Neighboring gene dynein light chain LC8-type 1 like 1 Neighboring gene uncharacterized LOC120102497 Neighboring gene elongin B, pseduogene 12 Neighboring gene single stranded DNA binding protein 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Biochemical and morphological characterization of MAGI-1 in neuronal tissue. Ito H, et al. J Neurosci Res, 2012 Sep. PMID 22605569
    2. Regulation of glutamate transporter GLT-1 by MAGI-1. Zou S, et al. J Neurochem, 2011 Jun. PMID 21426345
    3. MAGI-1a functions as a scaffolding protein for the distal renal tubular basolateral K+ channels. Tanemoto M, et al. J Biol Chem, 2008 May 2. PMID 18303016
    4. Magi-1 scaffolds Na(V)1.8 and Slack K(Na) channels in dorsal root ganglion neurons regulating excitability and pain. Pryce KD, et al. FASEB J, 2019 Jun. PMID 30860870, Free PMC Article
    5. MAGI-1, a membrane-associated guanylate kinase with a unique arrangement of protein-protein interaction domains. Dobrosotskaya I, et al. J Biol Chem, 1997 Dec 12. PMID 9395497

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-205-5p-Mediated MAGI1 Inhibition Attenuates the Injury Induced by Diabetic Nephropathy.
      Title: MiR-205-5p-Mediated MAGI1 Inhibition Attenuates the Injury Induced by Diabetic Nephropathy.
    2. Dorsal root ganglion (DRG)-specific knockdown of Magi-1 attenuated thermal nociception and acute inflammatory pain and NaV1.8 protein expression. Magi-1 bound to Slack potassium channels, macrocomplexing with NaV1.8 channels.Magi-1 is an essential scaffold for ion transport in DRG neurons and a central player in pain.Magi-1 is expressed in small- and medium-sized DRG neurons, their axonal tracts, and nodes of Ranvier.
      Title: Magi-1 scaffolds Na(V)1.8 and Slack K(Na) channels in dorsal root ganglion neurons regulating excitability and pain.
    3. MAGI-1 was expressed in Purkinje cells, in hypocampal neurons in CA1 region, in the glomerulus region of olfactory bulb, and at the dorsal root entry zone in embryonic rat spinal cord
      Title: Biochemical and morphological characterization of MAGI-1 in neuronal tissue.
    4. These results demonstrate that the phosphorylation-dependent scaffolding of the basolateral K(+) channels by MAGI-1a-long participates in the renal regulation of the fluid and electrolyte homeostasis.
      Title: MAGI-1a functions as a scaffolding protein for the distal renal tubular basolateral K+ channels.
    5. These data suggest that MAGI-1 regulates surface expression of GLT-1 and the level of glutamate in the hippocampus
      Title: Regulation of glutamate transporter GLT-1 by MAGI-1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-actinin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-actinin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in adherens junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
    Names
    BAI1-associated protein 1
    membrane-associated guanylate kinase inverted 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030045.2 → NP_001025216.2  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      Related
      ENSRNOP00000065881.3, ENSRNOT00000071315.4

    2. NM_001401825.1 → NP_001388754.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      127762590..128368228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236927.5 → XP_006236989.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Conserved Domains (6) summary
      smart00228
      Location:1151 → 1233
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303 → 332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:995 → 1090
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:361 → 390
      WW; WW domain
      pfam16666
      Location:721 → 804
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    2. XM_039108183.2 → XP_038964111.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X22

      UniProtKB/TrEMBL
      A0A8I6ABL7
      Related
      ENSRNOP00000090018.1
      Conserved Domains (6) summary
      smart00456
      Location:361 → 392
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1151 → 1233
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303 → 332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:995 → 1090
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:723 → 805
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    3. XM_039108192.2 → XP_038964120.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X40

      UniProtKB/TrEMBL
      A0A8I5Y118
      Related
      ENSRNOP00000077345.1
      Conserved Domains (6) summary
      smart00456
      Location:349 → 380
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1042 → 1124
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:805 → 880
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:711 → 798
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    4. XM_063286549.1 → XP_063142619.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X25

    5. XM_039108195.2 → XP_038964123.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X44

      UniProtKB/TrEMBL
      A0A8I6ABL7
      Conserved Domains (6) summary
      smart00456
      Location:349 → 380
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1110 → 1192
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303 → 332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:955 → 1049
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:711 → 799
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    6. XM_039108194.2 → XP_038964122.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X43

      UniProtKB/TrEMBL
      A0A8I6ABL7
      Conserved Domains (6) summary
      smart00456
      Location:349 → 380
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1138 → 1220
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303 → 332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:983 → 1077
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:711 → 793
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    7. XM_063286563.1 → XP_063142633.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X38

    8. XM_039108184.2 → XP_038964112.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X24

      UniProtKB/TrEMBL
      A0A8I6ABL7
      Conserved Domains (6) summary
      smart00456
      Location:361 → 392
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1150 → 1232
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303 → 332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:995 → 1089
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:723 → 805
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    9. XM_063286565.1 → XP_063142635.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X39

    10. XM_063286557.1 → XP_063142627.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X31

    11. XM_063286562.1 → XP_063142632.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X37

    12. XM_063286550.1 → XP_063142620.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X26

    13. XM_063286548.1 → XP_063142618.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X23

    14. XM_039108182.2 → XP_038964110.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X21

      UniProtKB/TrEMBL
      A0A8I6ABL7
      Conserved Domains (6) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1152 → 1234
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303 → 332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:996 → 1091
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:724 → 806
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    15. XM_063286541.1 → XP_063142611.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X6

    16. XM_039108176.2 → XP_038964104.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Conserved Domains (6) summary
      smart00456
      Location:361 → 392
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1150 → 1232
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:994 → 1089
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:723 → 804
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    17. XM_063286551.1 → XP_063142621.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X27

    18. XM_039108175.2 → XP_038964103.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Conserved Domains (6) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1151 → 1233
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:995 → 1090
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:724 → 805
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    19. XM_039108193.2 → XP_038964121.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X16

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Conserved Domains (6) summary
      smart00456
      Location:349 → 380
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1110 → 1192
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:955 → 1049
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:711 → 799
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    20. XM_063286543.1 → XP_063142613.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X14

    21. XM_006236929.5 → XP_006236991.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Conserved Domains (6) summary
      smart00228
      Location:1138 → 1220
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303 → 332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:983 → 1077
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:349 → 378
      WW; WW domain
      pfam16666
      Location:709 → 792
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    22. XM_039108177.2 → XP_038964105.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Conserved Domains (6) summary
      smart00456
      Location:349 → 380
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1139 → 1221
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:983 → 1078
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:711 → 793
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    23. XM_063286547.1 → XP_063142617.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X20

    24. XM_063286545.1 → XP_063142615.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X17

    25. XM_063286544.1 → XP_063142614.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X15

    26. XM_008763133.4 → XP_008761355.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X12

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Conserved Domains (6) summary
      smart00228
      Location:1122 → 1204
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303 → 332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:967 → 1061
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:361 → 390
      WW; WW domain
      pfam16666
      Location:721 → 804
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    27. XM_039108179.2 → XP_038964107.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A0G2JZE4, F1M7H7
      Related
      ENSRNOP00000033083.7
      Conserved Domains (6) summary
      smart00456
      Location:361 → 392
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1123 → 1205
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:967 → 1062
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:723 → 811
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    28. XM_063286546.1 → XP_063142616.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X19

    29. XM_063286542.1 → XP_063142612.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X13

    30. XM_039108178.2 → XP_038964106.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Conserved Domains (6) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1124 → 1206
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:968 → 1063
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:724 → 812
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    31. XM_039108181.2 → XP_038964109.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X18

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Conserved Domains (6) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1084 → 1166
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:847 → 922
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:724 → 806
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    32. XM_017592832.3 → XP_017448321.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A0G2JZE4

    33. XM_039108174.2 → XP_038964102.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Conserved Domains (6) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1151 → 1233
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:996 → 1090
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:724 → 806
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    34. XM_039108173.2 → XP_038964101.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Conserved Domains (6) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1152 → 1234
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:996 → 1091
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:724 → 806
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    35. XM_063286554.1 → XP_063142624.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28

    36. XM_063286553.1 → XP_063142623.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28

    37. XM_063286552.1 → XP_063142622.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28

    38. XM_063286567.1 → XP_063142637.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X42

    39. XM_063286559.1 → XP_063142629.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X33

    40. XM_063286560.1 → XP_063142630.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X34

    41. XM_039108188.2 → XP_038964116.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Conserved Domains (7) summary
      smart00456
      Location:135 → 166
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:925 → 1007
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:1044 → 1253
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:769 → 864
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:75 → 104
      WW; WW domain
      pfam16663
      Location:1 → 33
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:497 → 579
      MAGI_u5; Unstructured region on MAGI

    42. XM_063286566.1 → XP_063142636.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X41

    43. XM_063286555.1 → XP_063142625.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X29

    44. XM_039108191.2 → XP_038964119.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Related
      ENSRNOP00000071015.2
      Conserved Domains (7) summary
      smart00456
      Location:135 → 166
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:925 → 1007
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:1044 → 1253
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:769 → 864
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:75 → 104
      WW; WW domain
      pfam16663
      Location:1 → 33
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:497 → 579
      MAGI_u5; Unstructured region on MAGI

    45. XM_063286556.1 → XP_063142626.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X30

    46. XM_039108185.2 → XP_038964113.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28

      UniProtKB/TrEMBL
      A0A0G2JZE4
      Conserved Domains (7) summary
      smart00456
      Location:135 → 166
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:925 → 1007
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:1044 → 1253
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:769 → 864
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:75 → 104
      WW; WW domain
      pfam16663
      Location:1 → 33
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:497 → 579
      MAGI_u5; Unstructured region on MAGI

    47. XM_063286561.1 → XP_063142631.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X36

    48. XM_063286558.1 → XP_063142628.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X32

    49. XM_039108189.2 → XP_038964117.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X35

      UniProtKB/Swiss-Prot
      Q4L1J4, Q4L1J5
      Conserved Domains (6) summary
      smart00456
      Location:361 → 392
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:1123 → 1205
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:967 → 1062
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:723 → 811
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:122 → 293
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4L1J4.1 GenPept UniProtKB/Swiss-Prot:Q4L1J4

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