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    ADGRG3 adhesion G protein-coupled receptor G3 [ Homo sapiens (human) ]

    Gene ID: 222487, updated on 11-Apr-2024

    Summary

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    Official Symbol
    ADGRG3provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor G3provided by HGNC
    Primary source
    HGNC:HGNC:13728
    See related
    Ensembl:ENSG00000182885 MIM:618441; AllianceGenome:HGNC:13728
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PB99; GPR97; PGR26
    Summary
    Predicted to enable G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway and regulation of cell migration. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in bone marrow (RPKM 59.0), appendix (RPKM 9.5) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    16q21
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (57665629..57689378)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (63460829..63484584)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57702218..57723290)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371291 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10904 Neighboring gene high mobility group box 3 pseudogene 32 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10905 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57653277-57653781 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57653782-57654285 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57654286-57654790 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57656181-57657035 Neighboring gene Sharpr-MPRA regulatory region 10529 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57661723-57662378 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57662379-57663034 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57665003-57665658 Neighboring gene adhesion G protein-coupled receptor G1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:57685116-57685516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57692922-57693920 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57693921-57694919 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57710685-57711625 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10907 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10908 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10909 Neighboring gene dynein regulatory complex subunit 7 Neighboring gene MTCH2 pseudogene 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57767533-57768510 Neighboring gene uncharacterized LOC107984852 Neighboring gene Sharpr-MPRA regulatory region 7942 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7536 Neighboring gene katanin regulatory subunit B1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Curcumin activates G protein-coupled receptor 97 (GPR97) in a manner different from glucocorticoid. Harada N, et al. Biochem Biophys Res Commun, 2022 Mar 5. PMID 35093639
    2. The Adhesion G Protein-Coupled Receptor GPR97/ADGRG3 Is Expressed in Human Granulocytes and Triggers Antimicrobial Effector Functions. Hsiao CC, et al. Front Immunol, 2018. PMID 30559745, Free PMC Article
    3. Ca2+-binding modulator protein in protozoa and myxomycete. Kuźnicki J, et al. Cell Biol Int Rep, 1979 Jan. PMID 222487
    4. GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation. Chu TY, et al. Nat Commun, 2022 Oct 27. PMID 36302784, Free PMC Article
    5. Structures of the glucocorticoid-bound adhesion receptor GPR97-G(o) complex. Ping YQ, et al. Nature, 2021 Jan. PMID 33408414

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation.
      Title: GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation.
    2. Curcumin activates G protein-coupled receptor 97 (GPR97) in a manner different from glucocorticoid.
      Title: Curcumin activates G protein-coupled receptor 97 (GPR97) in a manner different from glucocorticoid.
    3. Structures of the glucocorticoid-bound adhesion receptor GPR97-Go complex.
      Title: Structures of the glucocorticoid-bound adhesion receptor GPR97-G(o) complex.
    4. Ligation of GPR97 increased the bacteria uptake.
      Title: The Adhesion G Protein-Coupled Receptor GPR97/ADGRG3 Is Expressed in Human Granulocytes and Triggers Antimicrobial Effector Functions.
    5. a possible role of GPR97 in lymphatic remodeling
      Title: The orphan adhesion G protein-coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in B cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of CREB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of non-canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor G3
    Names
    G protein-coupled receptor 97
    G-protein coupled receptor PGR26
    probable G-protein coupled receptor 97

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308360.2 → NP_001295289.1  adhesion G protein-coupled receptor G3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' UTR and 5' coding region resulting in the use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC018552, AK172801, AK301258, BC044222
      Consensus CDS
      CCDS76879.1
      UniProtKB/TrEMBL
      B4DVW2, F8W8F7
      Related
      ENSP00000404803.3, ENST00000450388.7
      Conserved Domains (2) summary
      pfam01825
      Location:93 → 135
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:148 → 397
      7tm_4; Olfactory receptor

    2. NM_170776.5 → NP_740746.4  adhesion G protein-coupled receptor G3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_740746.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC018552, BC064508, BE672513
      Consensus CDS
      CCDS10786.1
      UniProtKB/Swiss-Prot
      Q6ZMF4, Q86SL9, Q86Y34, Q8IZF1
      Related
      ENSP00000332900.4, ENST00000333493.9
      Conserved Domains (2) summary
      pfam01825
      Location:213 → 255
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:268 → 517
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      57665629..57689378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433780.1 → XP_047289736.1  adhesion G protein-coupled receptor G3 isoform X2

    2. XM_005255842.5 → XP_005255899.1  adhesion G protein-coupled receptor G3 isoform X1

      Conserved Domains (2) summary
      pfam01825
      Location:213 → 255
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:355 → 564
      7tm_4; Olfactory receptor

    3. XM_011522953.4 → XP_011521255.1  adhesion G protein-coupled receptor G3 isoform X4

      Conserved Domains (2) summary
      pfam01825
      Location:213 → 255
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:274 → 392
      7tm_4; Olfactory receptor

    4. XM_006721170.5 → XP_006721233.1  adhesion G protein-coupled receptor G3 isoform X6

      Conserved Domains (1) summary
      pfam01825
      Location:213 → 255
      GPS; GPCR proteolysis site, GPS, motif

    5. XM_011522954.3 → XP_011521256.1  adhesion G protein-coupled receptor G3 isoform X5

      Conserved Domains (1) summary
      pfam01825
      Location:213 → 255
      GPS; GPCR proteolysis site, GPS, motif

    6. XM_047433782.1 → XP_047289738.1  adhesion G protein-coupled receptor G3 isoform X7

      UniProtKB/TrEMBL
      H3BRU4
      Related
      ENSP00000456409.1, ENST00000567991.5

    7. XM_047433783.1 → XP_047289739.1  adhesion G protein-coupled receptor G3 isoform X8

    8. XM_047433781.1 → XP_047289737.1  adhesion G protein-coupled receptor G3 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      63460829..63484584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379819.1 → XP_054235794.1  adhesion G protein-coupled receptor G3 isoform X2

    2. XM_054379818.1 → XP_054235793.1  adhesion G protein-coupled receptor G3 isoform X1

    3. XM_054379821.1 → XP_054235796.1  adhesion G protein-coupled receptor G3 isoform X4

    4. XM_054379823.1 → XP_054235798.1  adhesion G protein-coupled receptor G3 isoform X6

    5. XM_054379822.1 → XP_054235797.1  adhesion G protein-coupled receptor G3 isoform X5

    6. XM_054379824.1 → XP_054235799.1  adhesion G protein-coupled receptor G3 isoform X7

      UniProtKB/TrEMBL
      H3BRU4

    7. XM_054379825.1 → XP_054235800.1  adhesion G protein-coupled receptor G3 isoform X8

    8. XM_054379820.1 → XP_054235795.1  adhesion G protein-coupled receptor G3 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86Y34.1 GenPept UniProtKB/Swiss-Prot:Q86Y34

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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