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    Mideas mitotic deacetylase associated SANT domain protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314306, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Mideasprovided by RGD
    Official Full Name
    mitotic deacetylase associated SANT domain proteinprovided by RGD
    Primary source
    RGD:1306119
    See related
    Ensembl:ENSRNOG00000010653 AllianceGenome:RGD:1306119
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Elmsan1; RGD1306119
    Summary
    Predicted to enable transcription corepressor activity. Predicted to be involved in histone deacetylation; negative regulation of transcription, DNA-templated; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of histone deacetylase complex and transcription regulator complex. Orthologous to human MIDEAS (mitotic deacetylase associated SANT domain protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 64.9), Lung (RPKM 48.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    6q31
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (109519011..109585631, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (103784779..103854470, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (107633762..107703462, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479231 Neighboring gene acyl-CoA thioesterase 6 Neighboring gene dynein, axonemal, light chain 1 Neighboring gene uncharacterized LOC120103573 Neighboring gene PNMA family member 1 Neighboring gene uncharacterized LOC134479232 Neighboring gene prostaglandin reductase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of histone deacetylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitotic deacetylase-associated SANT domain protein
    Names
    ELM2 and Myb/SANT domain containing 1
    ELM2 and Myb/SANT-like domain containing 1
    ELM2 and SANT domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001169116.2 → NP_001162587.1  mitotic deacetylase-associated SANT domain protein

      See identical proteins and their annotated locations for NP_001162587.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6JDT5, D4ACA6
      Related
      ENSRNOP00000014158.6, ENSRNOT00000014158.7
      Conserved Domains (2) summary
      pfam01448
      Location:715 → 770
      ELM2; ELM2 domain
      cl21498
      Location:824 → 868
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      109519011..109585631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764791.4 → XP_008763013.1  mitotic deacetylase-associated SANT domain protein isoform X1

      See identical proteins and their annotated locations for XP_008763013.1

      UniProtKB/TrEMBL
      A6JDT5, D4ACA6
      Conserved Domains (2) summary
      pfam01448
      Location:715 → 770
      ELM2; ELM2 domain
      cl21498
      Location:824 → 868
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    2. XM_039112308.2 → XP_038968236.1  mitotic deacetylase-associated SANT domain protein isoform X2

      UniProtKB/TrEMBL
      A6JDT5
      Conserved Domains (3) summary
      PHA03247
      Location:279 → 741
      PHA03247; large tegument protein UL36; Provisional
      pfam01448
      Location:715 → 770
      ELM2; ELM2 domain
      cl21498
      Location:824 → 868
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    Nucleotide Protein Strain
    Heading Accession and Version

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