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    Lama2 laminin subunit alpha 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309368, updated on 2-May-2024

    Summary

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    Official Symbol
    Lama2provided by RGD
    Official Full Name
    laminin subunit alpha 2provided by RGD
    Primary source
    RGD:1308889
    See related
    Ensembl:ENSRNOG00000011134 AllianceGenome:RGD:1308889
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be an extracellular matrix structural constituent. Involved in Schwann cell differentiation. Located in basement membrane and dendritic spine. Biomarker of renovascular hypertension. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy; congenital merosin-deficient muscular dystrophy 1A; muscular dystrophy; and myopia. Orthologous to human LAMA2 (laminin subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 674.5), Muscle (RPKM 322.3) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lama2 in Genome Data Viewer
    Location:
    1p12
    Exon count:
    67
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (19492126..20140056)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (17672675..18320641)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (18491264..19143486)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein lateral stalk subunit P0, pseudogene 4 Neighboring gene RuvB-like AAA ATPase 1, pseudogene 2 Neighboring gene U6 spliceosomal RNA Neighboring gene nucleophosmin 1, pseudogene 5 Neighboring gene uncharacterized LOC120098807 Neighboring gene U6 spliceosomal RNA Neighboring gene LSM5 homolog, U6 small nuclear RNA associated Neighboring gene Rho GTPase activating protein 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of the blood-testis barrier by a local axis in the testis: role of laminin α2 in the basement membrane. Gao Y, et al. FASEB J, 2017 Feb. PMID 27815338, Free PMC Article
    2. When do myopia genes have their effect? Comparison of genetic risks between children and adults. Tideman JW, et al. Genet Epidemiol, 2016 Dec. PMID 27611182
    3. Expression of dystroglycan complex in satellite cells of dorsal root ganglia. Masaki T, et al. Acta Neuropathol, 2001 Feb. PMID 11271373
    4. Expression of laminin alpha2 chain during normal and pathological growth of myocardium in rat and human. Oliviéro P, et al. Cardiovasc Res, 2000 May. PMID 10773239
    5. Expression of laminin-2 by normal and neoplastic rat C cells during the development of medullary thyroid carcinoma. Lekmine F, et al. Virchows Arch, 1999 Apr. PMID 10335943

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Laminin alpha2 in the basement membrane (BM) seems to play a crucial role in the blood-testis barrier-BM axis by modulating BTB dynamics during spermatogenesis.
      Title: Regulation of the blood-testis barrier by a local axis in the testis: role of laminin α2 in the basement membrane.
    2. Identification of cell adhesive sequences in the N-terminal region of the laminin alpha2 chain.
      Title: Identification of cell adhesive sequences in the N-terminal region of the laminin α2 chain.
    3. The binding of a small LG4-5 modules of laminin-211 to alpha-dystroglycan is important in preventing anoikis and that attachment plus binding is necessary for maximal cell survival.
      Title: LG4-5 domains of laminin-211 binds alpha-dystroglycan to allow myotube attachment and prevent anoikis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Schwann cell differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within axon guidance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of synaptic transmission, cholinergic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basement membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic cleft ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    laminin subunit alpha-2
    Names
    laminin, alpha 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427039.1 → NP_001413968.1  laminin subunit alpha-2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2JWX2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      19492126..20140056
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264627.1 → XP_063120697.1  laminin subunit alpha-2 isoform X1

    2. XM_063264628.1 → XP_063120698.1  laminin subunit alpha-2 isoform X2

    3. XM_063264630.1 → XP_063120700.1  laminin subunit alpha-2 isoform X4

    4. XM_063264632.1 → XP_063120702.1  laminin subunit alpha-2 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZPP7

    5. XM_063264629.1 → XP_063120699.1  laminin subunit alpha-2 isoform X3

    6. XM_063264637.1 → XP_063120707.1  laminin subunit alpha-2 isoform X6

    7. XM_063264642.1 → XP_063120712.1  laminin subunit alpha-2 isoform X7

      UniProtKB/TrEMBL
      A6JPF2
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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