GAS1 growth arrest specific 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GAS1provided by HGNC
Official Full Name: growth arrest specific 1provided by HGNC
Primary source: HGNC:HGNC:4165
See related: Ensembl:ENSG00000180447 MIM:139185; AllianceGenome:HGNC:4165
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene. [provided by RefSeq, Jul 2008]
Orthologs: mouse all
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Genomic context

Location:: 9q21.33

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (86944362..86947506, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (99095595..99098739, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (89559277..89562421, complement)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gas1 Regulates Patterning of the Murine and Human Dentitions through Sonic Hedgehog.
Title: Gas1 Regulates Patterning of the Murine and Human Dentitions through Sonic Hedgehog.
This study has identified Gas1 as a novel factor and mechanism through which microglia arrest the growth of human brain tumor-initiating cells for anti-tumor property.
Title: Microglia induces Gas1 expression in human brain tumor-initiating cells to reduce tumorigenecity.
t is relevant to investigate the potential additive effect of the overexpression of GAS1 and PTEN on tumor growth. In particular, we employed secreted forms of both GAS1 (tGAS1) and PTEN (PTEN-LONG, or PTEN-L) and tested their combined effect on glioma cells.
Title: Additive effects of the combined expression of soluble forms of GAS1 and PTEN inhibiting glioblastoma growth.
Studies establish Gas1 as a negative regulator in colorectal cancer.
Title: Gas1 Inhibits Metastatic and Metabolic Phenotypes in Colorectal Carcinoma.
These results demonstrated that miR-184 and the GAS1/Akt pathway may be a potential therapeutic target for intervertebral disc degeneration.
Title: MiR-184 Regulates Proliferation in Nucleus Pulposus Cells by Targeting GAS1.
WT1 modulates Akt/JNK signaling pathway mediated autophagy by controlling the expression of growth arrest-specific 1 (Gas1).
Title: WT1 is involved in the Akt-JNK pathway dependent autophagy through directly regulating Gas1 expression in human osteosarcoma cells.
Downregulation of GAS1 is associated with clear cell renal cell carcinoma.
Title: Downregulation of OCLN and GAS1 in clear cell renal cell carcinoma.
the synergistic effect of Gas1 inhibition and GDNF against glutamate-induced cell injury in human SH-SY5Y neuroblastoma cells, is reported.
Title: Gas1 Knockdown Increases the Neuroprotective Effect of Glial Cell-Derived Neurotrophic Factor Against Glutamate-Induced Cell Injury in Human SH-SY5Y Neuroblastoma Cells.
solutions structure and biophysical characterization of the multifaceted signalling effector protein growth arrest specific-1
Title: Solution structure and biophysical characterization of the multifaceted signalling effector protein growth arrest specific-1.
This review summarizes the structure of Gas1 and molecular mechanism of action during embryonic development and cellular functions.
Title: Gas1 is a pleiotropic regulator of cellular functions: from embryonic development to molecular actions in cancer gene therapy.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-L13698 (e-PCR)
- UniSTS:49534

NoName (e-PCR)
- UniSTS:486591

NoName (e-PCR)
- UniSTS:494527

WI-19256 (e-PCR)
- UniSTS:56798

NoName (e-PCR)
- UniSTS:482018

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables oxysterol binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell fate commitment	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to vascular endothelial growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in developmental growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ER to Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of smoothened signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: growth arrest-specific protein 1

Names: GAS-1; Growth arrest-specific gene-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.