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    Ermard ER membrane associated RNA degradation [ Mus musculus (house mouse) ]

    Gene ID: 381062, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Ermardprovided by MGI
    Official Full Name
    ER membrane associated RNA degradationprovided by MGI
    Primary source
    MGI:MGI:1917317
    See related
    Ensembl:ENSMUSG00000036552 AllianceGenome:MGI:1917317
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2210404J11Rik; 2410011O22Rik
    Summary
    Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ERMARD (ER membrane associated RNA degradation). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 5.1), cerebellum adult (RPKM 4.3) and 28 other tissues See more
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    Genomic context

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    Location:
    17 A2; 17 8.95 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (15261825..15310307)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (15041551..15090045)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene dynein light chain Tctex-type 2A2 Neighboring gene STARR-seq mESC enhancer starr_41899 Neighboring gene ER membrane associated RNA degradation like 1 Neighboring gene dynein light chain Tctex-type 2A1 Neighboring gene predicted gene, 52298 Neighboring gene STARR-seq mESC enhancer starr_41900 Neighboring gene predicted gene, 53990 Neighboring gene predicted gene, 35343 Neighboring gene predicted gene, 41532 Neighboring gene predicted gene, 35203 Neighboring gene predicted gene, 35455 Neighboring gene STARR-seq mESC enhancer starr_41901 Neighboring gene predicted gene, 35502

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Vertebrate Genome Annotation browser 10 years on. Harrow JL, et al. Nucleic Acids Res, 2014 Jan. PMID 24316575, Free PMC Article
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    ER membrane associated RNA degradation

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039552.4 → NP_001034641.2  ER membrane associated RNA degradation isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC182749
      Consensus CDS
      CCDS37451.1
      UniProtKB/TrEMBL
      B9EKF9, E9Q048
      Related
      ENSMUSP00000095005.4, ENSMUST00000097393.11
      Conserved Domains (1) summary
      pfam13910
      Location:133 → 214
      DUF4209; Domain of unknown function (DUF4209)

    2. NM_001360400.2 → NP_001347329.1  ER membrane associated RNA degradation isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC182749
      Conserved Domains (1) summary
      pfam13910
      Location:7 → 88
      DUF4209; Domain of unknown function (DUF4209)

    3. NM_001360401.2 → NP_001347330.1  ER membrane associated RNA degradation isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC182749

    4. NM_001360402.2 → NP_001347331.1  ER membrane associated RNA degradation isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC182749
      Conserved Domains (1) summary
      pfam13910
      Location:7 → 88
      DUF4209; Domain of unknown function (DUF4209)

    5. NM_001405474.2 → NP_001392403.1  ER membrane associated RNA degradation isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC182749

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      15261825..15310307
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160659.1 → XP_036016552.1  ER membrane associated RNA degradation isoform X10

      UniProtKB/TrEMBL
      B9EKF9
      Conserved Domains (1) summary
      pfam13910
      Location:133 → 214
      DUF4209; Domain of unknown function (DUF4209)

    2. XM_036160660.1 → XP_036016553.1  ER membrane associated RNA degradation isoform X13

      UniProtKB/TrEMBL
      B9EKF9
      Conserved Domains (1) summary
      pfam13910
      Location:133 → 214
      DUF4209; Domain of unknown function (DUF4209)

    3. XM_036160662.1 → XP_036016555.1  ER membrane associated RNA degradation isoform X17

      UniProtKB/TrEMBL
      B9EKF9
      Conserved Domains (1) summary
      pfam13910
      Location:133 → 214
      DUF4209; Domain of unknown function (DUF4209)

    4. XM_030249856.2 → XP_030105716.1  ER membrane associated RNA degradation isoform X20

      Conserved Domains (1) summary
      pfam13910
      Location:7 → 88
      DUF4209; Domain of unknown function (DUF4209)

    5. XM_036160664.1 → XP_036016557.1  ER membrane associated RNA degradation isoform X21

      Conserved Domains (1) summary
      pfam13910
      Location:7 → 88
      DUF4209; Domain of unknown function (DUF4209)

    6. XM_036160665.1 → XP_036016558.1  ER membrane associated RNA degradation isoform X23

      Conserved Domains (1) summary
      pfam13910
      Location:62 → 151
      DUF4209; Domain of unknown function (DUF4209)

    7. XM_036160666.1 → XP_036016559.1  ER membrane associated RNA degradation isoform X23

      Conserved Domains (1) summary
      pfam13910
      Location:62 → 151
      DUF4209; Domain of unknown function (DUF4209)

    8. XM_030249854.1 → XP_030105714.1  ER membrane associated RNA degradation isoform X19

      Conserved Domains (1) summary
      pfam13910
      Location:62 → 151
      DUF4209; Domain of unknown function (DUF4209)

    9. XM_006524461.2 → XP_006524524.1  ER membrane associated RNA degradation isoform X4

      UniProtKB/TrEMBL
      B9EKF9
      Conserved Domains (1) summary
      pfam13910
      Location:125 → 206
      DUF4209; Domain of unknown function (DUF4209)

    10. XM_030249851.1 → XP_030105711.1  ER membrane associated RNA degradation isoform X12

      UniProtKB/TrEMBL
      B9EKF9
      Conserved Domains (1) summary
      pfam13910
      Location:125 → 206
      DUF4209; Domain of unknown function (DUF4209)

    11. XM_030249852.1 → XP_030105712.1  ER membrane associated RNA degradation isoform X14

      UniProtKB/TrEMBL
      B9EKF9
      Conserved Domains (1) summary
      pfam13910
      Location:125 → 206
      DUF4209; Domain of unknown function (DUF4209)

    12. XM_006524460.5 → XP_006524523.1  ER membrane associated RNA degradation isoform X3

      UniProtKB/TrEMBL
      B9EKF9
      Conserved Domains (1) summary
      pfam13910
      Location:132 → 213
      DUF4209; Domain of unknown function (DUF4209)

    13. XM_006524463.3 → XP_006524526.1  ER membrane associated RNA degradation isoform X8

      UniProtKB/TrEMBL
      B9EKF9
      Conserved Domains (1) summary
      pfam13910
      Location:157 → 238
      DUF4209; Domain of unknown function (DUF4209)

    14. XM_011246509.3 → XP_011244811.1  ER membrane associated RNA degradation isoform X5

      UniProtKB/TrEMBL
      B9EKF9
      Conserved Domains (1) summary
      pfam13910
      Location:157 → 238
      DUF4209; Domain of unknown function (DUF4209)

    15. XM_036160661.1 → XP_036016554.1  ER membrane associated RNA degradation isoform X15

      UniProtKB/TrEMBL
      B9EKF9
      Conserved Domains (1) summary
      pfam13910
      Location:157 → 238
      DUF4209; Domain of unknown function (DUF4209)

    16. XM_011246510.3 → XP_011244812.1  ER membrane associated RNA degradation isoform X6

      UniProtKB/TrEMBL
      B9EKF9
      Conserved Domains (1) summary
      pfam13910
      Location:157 → 238
      DUF4209; Domain of unknown function (DUF4209)

    17. XM_006524462.4 → XP_006524525.1  ER membrane associated RNA degradation isoform X7

      UniProtKB/TrEMBL
      B9EKF9
      Conserved Domains (1) summary
      pfam13910
      Location:157 → 238
      DUF4209; Domain of unknown function (DUF4209)

    18. XM_006524458.3 → XP_006524521.1  ER membrane associated RNA degradation isoform X1

      UniProtKB/TrEMBL
      B9EKF9
      Conserved Domains (1) summary
      pfam13910
      Location:157 → 238
      DUF4209; Domain of unknown function (DUF4209)

    19. XM_006524464.3 → XP_006524527.1  ER membrane associated RNA degradation isoform X9

      UniProtKB/TrEMBL
      B9EKF9
      Conserved Domains (1) summary
      pfam13910
      Location:157 → 238
      DUF4209; Domain of unknown function (DUF4209)

    20. XM_006524465.3 → XP_006524528.1  ER membrane associated RNA degradation isoform X11

      UniProtKB/TrEMBL
      B9EKF9
      Conserved Domains (1) summary
      pfam13910
      Location:157 → 238
      DUF4209; Domain of unknown function (DUF4209)

    21. XM_006524466.4 → XP_006524529.1  ER membrane associated RNA degradation isoform X16

      UniProtKB/TrEMBL
      B9EKF9
      Conserved Domains (1) summary
      pfam13910
      Location:157 → 238
      DUF4209; Domain of unknown function (DUF4209)

    22. XM_030249855.2 → XP_030105715.1  ER membrane associated RNA degradation isoform X19

      Conserved Domains (1) summary
      pfam13910
      Location:62 → 151
      DUF4209; Domain of unknown function (DUF4209)

    23. XM_030249858.2 → XP_030105718.1  ER membrane associated RNA degradation isoform X23

      Conserved Domains (1) summary
      pfam13910
      Location:62 → 151
      DUF4209; Domain of unknown function (DUF4209)

    24. XM_030249857.1 → XP_030105717.1  ER membrane associated RNA degradation isoform X22

      Conserved Domains (1) summary
      pfam13910
      Location:62 → 151
      DUF4209; Domain of unknown function (DUF4209)

    25. XM_030249853.2 → XP_030105713.1  ER membrane associated RNA degradation isoform X18

      Conserved Domains (1) summary
      pfam13910
      Location:1 → 45
      DUF4209; Domain of unknown function (DUF4209)

    26. XM_036160663.1 → XP_036016556.1  ER membrane associated RNA degradation isoform X18

      Conserved Domains (1) summary
      pfam13910
      Location:1 → 45
      DUF4209; Domain of unknown function (DUF4209)

    RNA

    1. XR_004939545.1 RNA Sequence

    2. XR_385340.3 RNA Sequence

    3. XR_876519.3 RNA Sequence

    4. XR_876517.3 RNA Sequence

    5. XR_385342.3 RNA Sequence

    6. XR_004939544.1 RNA Sequence

    7. XR_003952143.2 RNA Sequence

    8. XR_004939543.1 RNA Sequence

    9. XR_003952144.2 RNA Sequence

    10. XR_003952142.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001034891.3: Suppressed sequence

      Description
      NM_001034891.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.

    2. NM_183133.1: Suppressed sequence

      Description
      NM_183133.1: This RefSeq was temporarily suppressed because its source sequence, AK019108.1, does not represent an intron/exon definition that is supported by other available sequence data.

    3. NM_198646.1: Suppressed sequence

      Description
      NM_198646.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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