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    Pla2g6 phospholipase A2, group VI [ Mus musculus (house mouse) ]

    Gene ID: 53357, updated on 4-May-2024

    Summary

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    Official Symbol
    Pla2g6provided by MGI
    Official Full Name
    phospholipase A2, group VIprovided by MGI
    Primary source
    MGI:MGI:1859152
    See related
    Ensembl:ENSMUSG00000042632 AllianceGenome:MGI:1859152
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    iPLA2; PNPLA9; iPLA2beta; iPLA(2)beta
    Summary
    Enables calcium-independent phospholipase A2 activity; palmitoyl-CoA hydrolase activity; and serine hydrolase activity. Involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in centriolar satellite; cytosol; and extracellular space. Predicted to be active in mitochondrion. Is expressed in 1st branchial arch maxillary component; olfactory placode; otic pit; and trunk somite. Used to study neurodegeneration with brain iron accumulation 2a. Human ortholog(s) of this gene implicated in dystonia 12; neuroaxonal dystrophy; and neurodegenerative disease (multiple). Orthologous to human PLA2G6 (phospholipase A2 group VI). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 76.7), adrenal adult (RPKM 14.0) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 E1; 15 37.7 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79170428..79212915, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79286228..79328385, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene lectin, galactose binding, soluble 1, pseudogene 2 Neighboring gene BAI1-associated protein 2-like 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:79110794-79110903 Neighboring gene predicted gene, 41358 Neighboring gene STARR-positive B cell enhancer ABC_E7389 Neighboring gene predicted gene 20420 Neighboring gene STARR-positive B cell enhancer ABC_E1913 Neighboring gene STARR-seq mESC enhancer starr_39174 Neighboring gene v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) Neighboring gene transmembrane protein 184b Neighboring gene microRNA 1943

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. iPLA2β-Null Mice Show HCC Protection by an Induction of Cell-Cycle Arrest after Diethylnitrosamine Treatment. Andrade A, et al. Int J Mol Sci, 2022 Nov 9. PMID 36430237, Free PMC Article
    2. Myeloid- and hepatocyte-specific deletion of group VIA calcium-independent phospholipase A2 leads to dichotomous opposing phenotypes during MCD diet-induced NASH. Jansakun C, et al. Biochim Biophys Acta Mol Basis Dis, 2023 Jan 1. PMID 36334837
    3. Acidic Calcium-Independent Phospholipase A2 Regulates Eosinophil-Mediated Pathology during Filarial Manifestation of Tropical Pulmonary Eosinophilia. Sharma P, et al. J Immunol, 2021 Feb 15. PMID 33441441
    4. Rescue of Hepatic Phospholipid Remodeling Defectin iPLA2β-Null Mice Attenuates Obese but Not Non-Obese Fatty Liver. Chamulitrat W, et al. Biomolecules, 2020 Sep 17. PMID 32957701, Free PMC Article
    5. Loss of tyrosine hydroxylase, motor deficits and elevated iron in a mouse model of phospholipase A2G6-associated neurodegeneration (PLAN). Minkley M, et al. Brain Res, 2020 Dec 1. PMID 32818532

    See all (117) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Myeloid-specific deletion of group VIA calcium-independent phospholipase A2 induces pro-inflammatory LPS response predominantly in male mice via MIP-1alpha activation.
      Title: Myeloid-specific deletion of group VIA calcium-independent phospholipase A2 induces pro-inflammatory LPS response predominantly in male mice via MIP-1α activation.
    2. PLA2G6 mutations cause motor dysfunction phenotypes of young-onset dystonia-parkinsonism type 14 and can be relieved by DHA treatment in animal models.
      Title: PLA2G6 mutations cause motor dysfunction phenotypes of young-onset dystonia-parkinsonism type 14 and can be relieved by DHA treatment in animal models.
    3. iPLA2beta Contributes to ER Stress-Induced Apoptosis during Myocardial Ischemia/Reperfusion Injury.
      Title: iPLA(2)β Contributes to ER Stress-Induced Apoptosis during Myocardial Ischemia/Reperfusion Injury.
    4. Rescue of Hepatic Phospholipid Remodeling Defectin iPLA2beta-Null Mice Attenuates Obese but Not Non-Obese Fatty Liver.
      Title: Rescue of Hepatic Phospholipid Remodeling Defectin iPLA2β-Null Mice Attenuates Obese but Not Non-Obese Fatty Liver.
    5. Acidic Calcium-Independent Phospholipase A2 Regulates Eosinophil-Mediated Pathology during Filarial Manifestation of Tropical Pulmonary Eosinophilia.
      Title: Acidic Calcium-Independent Phospholipase A2 Regulates Eosinophil-Mediated Pathology during Filarial Manifestation of Tropical Pulmonary Eosinophilia.
    6. iPLA2beta-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4.
      Title: iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4.
    7. Metabolic Effects of Selective Deletion of Group VIA Phospholipase A2 from Macrophages or Pancreatic Islet Beta-Cells.
      Title: Metabolic Effects of Selective Deletion of Group VIA Phospholipase A(2) from Macrophages or Pancreatic Islet Beta-Cells.
    8. Type 1 interferon-dependent repression of NLRC4 and iPLA2 licenses down-regulation of Salmonella flagellin inside macrophages.
      Title: Type 1 interferon-dependent repression of NLRC4 and iPLA2 licenses down-regulation of Salmonella flagellin inside macrophages.
    9. This study provides insights into iPla2b (PLA2G6) inactivation for injury susceptibility under normal conditions and liver fibrosis and cholangiopathies during methionine-choline-deficient diet feeding.
      Title: iPla2β Deficiency Suppresses Hepatic ER UPR, Fxr, and Phospholipids in Mice Fed with MCD Diet, Resulting in Exacerbated Hepatic Bile Acids and Biliary Cell Proliferation.
    10. the regulation of iPLA2beta/Cardiolipin/Opa1 by HGSD may prevent beta-cell apoptosis and may improve islet beta-cell function in Type 2 diabetic mice and in palmitate-treated MIN6 cells
      Title: Amorphous solid dispersion of Berberine mitigates apoptosis via iPLA(2)β/Cardiolipin/Opa1 pathway in db/db mice and in Palmitate-treated MIN6 β-cells.
    Submit: New GeneRIF Correction See all GeneRIFs (73)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (7)  1 citation
    • Chemically induced (ENU) (1) 
    • Spontaneous (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-independent phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-independent phospholipase A2 activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables calcium-independent phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acyl-CoA hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables long-chain fatty acyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lysophospholipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidyl phospholipase B activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antibacterial humoral response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cardiolipin acyl-chain remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cardiolipin acyl-chain remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cardiolipin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in memory ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylcholine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of arachidonic acid secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein kinase C signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in urinary bladder smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vasodilation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    85/88 kDa calcium-independent phospholipase A2
    Names
    2-lysophosphatidylcholine acylhydrolase
    85 kDa calcium-independent phospholipase A2
    GVI PLA2
    caI-PLA2
    group VI phospholipase A2
    iPLA2-beta
    intracellular membrane-associated calcium-independent phospholipase A2 beta
    palmitoyl-CoA hydrolase
    patatin-like phospholipase domain-containing protein 9
    NP_001185952.1
    NP_001185953.1
    NP_001185954.1
    NP_001403319.1
    NP_001403320.1
    NP_001403321.1
    NP_001403322.1
    NP_001403324.1
    NP_001403325.1
    NP_001403326.1
    NP_001403327.1
    NP_001403328.1
    NP_001403329.1
    NP_001403333.1
    NP_058611.1
    XP_036015396.1
    XP_036015397.1
    XP_036015398.1
    XP_036015399.1
    XP_036015400.1
    XP_036015401.1
    XP_036015402.1
    XP_036015403.1
    XP_036015404.1
    XP_036015405.1
    XP_036015406.1
    XP_036015407.1
    XP_036015409.1
    XP_036015410.1
    XP_036015411.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199023.2 → NP_001185952.1  85/88 kDa calcium-independent phospholipase A2 isoform 2

      See identical proteins and their annotated locations for NP_001185952.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has an additional in-frame exon in the coding region, compared to variant 1. It encodes a longer isoform (2) than isoform 1.
      Source sequence(s)
      AC165278, AL591913
      Consensus CDS
      CCDS56991.1
      UniProtKB/Swiss-Prot
      P97819, Q99LA9, Q9JK61
      UniProtKB/TrEMBL
      Q3U613, Q7TPX2
      Related
      ENSMUSP00000134672.2, ENSMUST00000174021.8
      Conserved Domains (5) summary
      cd07212
      Location:481 → 794
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      PHA02875
      Location:220 → 412
      PHA02875; ankyrin repeat protein; Provisional
      sd00045
      Location:286 → 314
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:156 → 248
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:103 → 183
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_001199024.2 → NP_001185953.1  85/88 kDa calcium-independent phospholipase A2 isoform 1

      See identical proteins and their annotated locations for NP_001185953.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1, and encodes isoform (1). Variants 1, 3, and 4 encode the same protein (isoform 1).
      Source sequence(s)
      AC165278, AL591913
      Consensus CDS
      CCDS27637.1
      UniProtKB/TrEMBL
      Q3U613, Q3UN31, Q7TPX2
      Related
      ENSMUSP00000132071.3, ENSMUST00000166977.9
      Conserved Domains (5) summary
      cd07212
      Location:426 → 739
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      PHA02875
      Location:220 → 390
      PHA02875; ankyrin repeat protein; Provisional
      sd00045
      Location:286 → 314
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:156 → 248
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:103 → 183
      Ank_2; Ankyrin repeats (3 copies)

    3. NM_001199025.2 → NP_001185954.1  85/88 kDa calcium-independent phospholipase A2 isoform 1

      See identical proteins and their annotated locations for NP_001185954.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1, and encodes isoform (1). Variants 1, 3, and 4 encode the same protein (isoform 1).
      Source sequence(s)
      AC165278, AL591913
      Consensus CDS
      CCDS27637.1
      UniProtKB/TrEMBL
      Q3U613, Q3UN31, Q7TPX2
      Related
      ENSMUSP00000131081.3, ENSMUST00000172403.9
      Conserved Domains (5) summary
      cd07212
      Location:426 → 739
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      PHA02875
      Location:220 → 390
      PHA02875; ankyrin repeat protein; Provisional
      sd00045
      Location:286 → 314
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:156 → 248
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:103 → 183
      Ank_2; Ankyrin repeats (3 copies)

    4. NM_001416390.1 → NP_001403319.1  85/88 kDa calcium-independent phospholipase A2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC165278, AL591913
      UniProtKB/TrEMBL
      Q3UN31

    5. NM_001416391.1 → NP_001403320.1  85/88 kDa calcium-independent phospholipase A2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC165278, AL591913
      UniProtKB/TrEMBL
      Q3UN31
      Related
      ENSMUSP00000134456.2, ENSMUST00000173163.8

    6. NM_001416392.1 → NP_001403321.1  85/88 kDa calcium-independent phospholipase A2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC165278, AL591913
      UniProtKB/TrEMBL
      Q3UN31

    7. NM_001416393.1 → NP_001403322.1  85/88 kDa calcium-independent phospholipase A2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC165278, AL591913
      UniProtKB/TrEMBL
      Q3UN31

    8. NM_001416395.1 → NP_001403324.1  85/88 kDa calcium-independent phospholipase A2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL591913
      UniProtKB/TrEMBL
      Q3UN31

    9. NM_001416396.1 → NP_001403325.1  85/88 kDa calcium-independent phospholipase A2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC165278, AL591913
      UniProtKB/Swiss-Prot
      P97819, Q99LA9, Q9JK61

    10. NM_001416397.1 → NP_001403326.1  85/88 kDa calcium-independent phospholipase A2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC165278, AL591913
      UniProtKB/Swiss-Prot
      P97819, Q99LA9, Q9JK61

    11. NM_001416398.1 → NP_001403327.1  85/88 kDa calcium-independent phospholipase A2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC165278, AL591913
      UniProtKB/Swiss-Prot
      P97819, Q99LA9, Q9JK61

    12. NM_001416399.1 → NP_001403328.1  85/88 kDa calcium-independent phospholipase A2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC165278, AL591913
      UniProtKB/Swiss-Prot
      P97819, Q99LA9, Q9JK61

    13. NM_001416400.1 → NP_001403329.1  85/88 kDa calcium-independent phospholipase A2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC165278, AL591913

    14. NM_001416404.1 → NP_001403333.1  85/88 kDa calcium-independent phospholipase A2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC165278, AL591913

    15. NM_016915.5 → NP_058611.1  85/88 kDa calcium-independent phospholipase A2 isoform 1

      See identical proteins and their annotated locations for NP_058611.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (1). Variants 1, 3, and 4 encode the same protein (isoform 1).
      Source sequence(s)
      AC165278, AL591913
      Consensus CDS
      CCDS27637.1
      UniProtKB/TrEMBL
      Q3U613, Q3UN31, Q7TPX2
      Related
      ENSMUSP00000044234.9, ENSMUST00000047816.15
      Conserved Domains (5) summary
      cd07212
      Location:426 → 739
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      PHA02875
      Location:220 → 390
      PHA02875; ankyrin repeat protein; Provisional
      sd00045
      Location:286 → 314
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:156 → 248
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:103 → 183
      Ank_2; Ankyrin repeats (3 copies)

    RNA

    1. NR_183841.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC165278, AL591913

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      79170428..79212915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159506.1 → XP_036015399.1  85/88 kDa calcium-independent phospholipase A2 isoform X1

      Conserved Domains (5) summary
      cd07212
      Location:481 → 940
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      PHA02875
      Location:220 → 412
      PHA02875; ankyrin repeat protein; Provisional
      sd00045
      Location:286 → 314
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:156 → 249
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:103 → 183
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_036159511.1 → XP_036015404.1  85/88 kDa calcium-independent phospholipase A2 isoform X1

      Conserved Domains (5) summary
      cd07212
      Location:481 → 940
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      PHA02875
      Location:220 → 412
      PHA02875; ankyrin repeat protein; Provisional
      sd00045
      Location:286 → 314
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:156 → 249
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:103 → 183
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_036159504.1 → XP_036015397.1  85/88 kDa calcium-independent phospholipase A2 isoform X1

      Conserved Domains (5) summary
      cd07212
      Location:481 → 940
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      PHA02875
      Location:220 → 412
      PHA02875; ankyrin repeat protein; Provisional
      sd00045
      Location:286 → 314
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:156 → 249
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:103 → 183
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_036159507.1 → XP_036015400.1  85/88 kDa calcium-independent phospholipase A2 isoform X1

      Conserved Domains (5) summary
      cd07212
      Location:481 → 940
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      PHA02875
      Location:220 → 412
      PHA02875; ankyrin repeat protein; Provisional
      sd00045
      Location:286 → 314
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:156 → 249
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:103 → 183
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_036159514.1 → XP_036015407.1  85/88 kDa calcium-independent phospholipase A2 isoform X2

      UniProtKB/TrEMBL
      Q3U613, Q7TPX2
      Conserved Domains (3) summary
      cd07212
      Location:426 → 885
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      sd00045
      Location:286 → 314
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:156 → 249
      Ank_2; Ankyrin repeats (3 copies)

    6. XM_036159512.1 → XP_036015405.1  85/88 kDa calcium-independent phospholipase A2 isoform X1

      Conserved Domains (5) summary
      cd07212
      Location:481 → 940
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      PHA02875
      Location:220 → 412
      PHA02875; ankyrin repeat protein; Provisional
      sd00045
      Location:286 → 314
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:156 → 249
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:103 → 183
      Ank_2; Ankyrin repeats (3 copies)

    7. XM_036159503.1 → XP_036015396.1  85/88 kDa calcium-independent phospholipase A2 isoform X1

      Conserved Domains (5) summary
      cd07212
      Location:481 → 940
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      PHA02875
      Location:220 → 412
      PHA02875; ankyrin repeat protein; Provisional
      sd00045
      Location:286 → 314
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:156 → 249
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:103 → 183
      Ank_2; Ankyrin repeats (3 copies)

    8. XM_036159505.1 → XP_036015398.1  85/88 kDa calcium-independent phospholipase A2 isoform X1

      Conserved Domains (5) summary
      cd07212
      Location:481 → 940
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      PHA02875
      Location:220 → 412
      PHA02875; ankyrin repeat protein; Provisional
      sd00045
      Location:286 → 314
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:156 → 249
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:103 → 183
      Ank_2; Ankyrin repeats (3 copies)

    9. XM_036159513.1 → XP_036015406.1  85/88 kDa calcium-independent phospholipase A2 isoform X2

      UniProtKB/TrEMBL
      Q3U613, Q7TPX2
      Conserved Domains (3) summary
      cd07212
      Location:426 → 885
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      sd00045
      Location:286 → 314
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:156 → 249
      Ank_2; Ankyrin repeats (3 copies)

    10. XM_036159517.1 → XP_036015410.1  85/88 kDa calcium-independent phospholipase A2 isoform X5

      Conserved Domains (1) summary
      cd07212
      Location:26 → 485
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9

    11. XM_036159516.1 → XP_036015409.1  85/88 kDa calcium-independent phospholipase A2 isoform X2

      UniProtKB/TrEMBL
      Q3U613, Q7TPX2
      Conserved Domains (3) summary
      cd07212
      Location:426 → 885
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      sd00045
      Location:286 → 314
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:156 → 249
      Ank_2; Ankyrin repeats (3 copies)

    12. XM_036159508.1 → XP_036015401.1  85/88 kDa calcium-independent phospholipase A2 isoform X1

      Conserved Domains (5) summary
      cd07212
      Location:481 → 940
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      PHA02875
      Location:220 → 412
      PHA02875; ankyrin repeat protein; Provisional
      sd00045
      Location:286 → 314
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:156 → 249
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:103 → 183
      Ank_2; Ankyrin repeats (3 copies)

    13. XM_036159509.1 → XP_036015402.1  85/88 kDa calcium-independent phospholipase A2 isoform X1

      Conserved Domains (5) summary
      cd07212
      Location:481 → 940
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      PHA02875
      Location:220 → 412
      PHA02875; ankyrin repeat protein; Provisional
      sd00045
      Location:286 → 314
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:156 → 249
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:103 → 183
      Ank_2; Ankyrin repeats (3 copies)

    14. XM_036159510.1 → XP_036015403.1  85/88 kDa calcium-independent phospholipase A2 isoform X1

      Conserved Domains (5) summary
      cd07212
      Location:481 → 940
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
      PHA02875
      Location:220 → 412
      PHA02875; ankyrin repeat protein; Provisional
      sd00045
      Location:286 → 314
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:156 → 249
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:103 → 183
      Ank_2; Ankyrin repeats (3 copies)

    15. XM_036159518.1 → XP_036015411.1  85/88 kDa calcium-independent phospholipase A2 isoform X5

      Conserved Domains (1) summary
      cd07212
      Location:26 → 485
      Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9

    RNA

    1. XR_004938853.1 RNA Sequence

    2. XR_003951405.1 RNA Sequence

    3. XR_004938855.1 RNA Sequence

    4. XR_004938854.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97819.3 GenPept UniProtKB/Swiss-Prot:P97819

    Gene LinkOut

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