kri1 KRI1 homolog [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kri1provided by ZNC
Official Full Name: KRI1 homologprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040915-3
See related: Ensembl:ENSDARG00000075380 AllianceGenome:ZFIN:ZDB-GENE-040915-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: kri1l; flj12949l
Summary: Acts upstream of or within definitive hemopoiesis and ribosome biogenesis. Predicted to be part of 90S preribosome. Predicted to be active in nucleolus. Is expressed in eye; immature eye; and somite. Orthologous to human KRI1 (KRI1 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (19336501..19355200)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (19186761..19205460)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kri1l is required for normal ribosome biogenesis, expansion of definitive hematopoietic stem/progenitor cells and subsequent lineage differentiation
Title: Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction.

Submit: New GeneRIF Correction

General gene information

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Markers

fc22d07.y1 (e-PCR)
- UniSTS:193093

fe05d11.y1 (e-PCR)
- UniSTS:195985

fi23b06.x1 (e-PCR)
- UniSTS:197060

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within definitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ribosome biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of 90S preribosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein KRI1 homolog

Names: KRI1 homolog like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.