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    NPY2R neuropeptide Y receptor Y2 [ Homo sapiens (human) ]

    Gene ID: 4887, updated on 5-Mar-2024

    Summary

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    Official Symbol
    NPY2Rprovided by HGNC
    Official Full Name
    neuropeptide Y receptor Y2provided by HGNC
    Primary source
    HGNC:HGNC:7957
    See related
    Ensembl:ENSG00000185149 MIM:162642; AllianceGenome:HGNC:7957
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NPY2-R
    Summary
    Predicted to enable calcium channel regulator activity and neuropeptide Y receptor activity. Involved in cardiac left ventricle morphogenesis and outflow tract morphogenesis. Located in cilium. Implicated in Huntington's disease; morbid obesity; and obesity. Biomarker of peripheral artery disease and temporal lobe epilepsy. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

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    Location:
    4q32.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (155173723..155217076)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (158505608..158548978)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (156094875..156138228)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U2 small nuclear 44, pseudogene Neighboring gene RNA binding motif protein 46 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:155837105-155837739 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:155875070-155875570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:155875571-155876071 Neighboring gene uncharacterized LOC105377501 Neighboring gene NANOG hESC enhancer GRCh37_chr4:156034857-156035436 Neighboring gene NPY2R antisense RNA 1 Neighboring gene uncharacterized LOC105377502 Neighboring gene MAP9 antisense RNA 1 Neighboring gene microtubule associated protein 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Association between neuropeptide Y receptor Y2 promoter variant rs6857715 and major depressive disorder. Treutlein J, et al. Psychiatr Genet, 2017 Feb. PMID 27584037
    2. On the relevance of the NPY2-receptor variation for modes of action cascading processes. Beste C, et al. Neuroimage, 2014 Nov 15. PMID 25157429
    3. NPY2-receptor variation modulates iconic memory processes. Arning L, et al. Eur Neuropsychopharmacol, 2014 Aug. PMID 24709141
    4. The G-protein-coupled neuropeptide Y receptor type 2 is highly dynamic in lipid membranes as revealed by solid-state NMR spectroscopy. Schmidt P, et al. Chemistry, 2014 Apr 22. PMID 24623336
    5. Ligands of the neuropeptide Y Y2 receptor. Mittapalli GK, et al. Bioorg Med Chem Lett, 2014 Jan 15. PMID 24365162, Free PMC Article

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling.
      Title: Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling.
    2. Inhibition of epileptiform activity by neuropeptide Y in brain tissue from drug-resistant temporal lobe epilepsy patients.
      Title: Inhibition of epileptiform activity by neuropeptide Y in brain tissue from drug-resistant temporal lobe epilepsy patients.
    3. The analysis of the distribution of genotypes in CEP135 rs4865047 and NPY2R rs1902491 detected significant differences only in the single nucleotide polymorphism rs4865047 genotype between the case and control group in comparison to the reference group. No significant association was found for the NPY2R SNP rs1902491 genotype.
      Title: The Association of CEP135 rs4865047 and NPY2R rs1902491 Single Nucleotide Polymorphisms (SNPs) with Rapid Progression of Proliferative Diabetic Retinopathy in Patients with Type 1 Diabetes Mellitus.
    4. genetic variation in NPY and NPY2R is at low frequency and thus does not make a major contribution to the obese phenotype in the general population
      Title: Evaluation of a Role for NPY and NPY2R in the Pathogenesis of Obesity by Mutation and Copy Number Variation Analysis in Obese Children and Adolescents.
    5. The present study explored whether functional NPY2R variant rs6857715 (C-599T) showed an association with Major Depressive Disorder. Analysis of the overall sample (595 MDD cases; 1295 controls) showed an association with the AD risk allele C. The present findings suggest that the NPY2R rs6857715 C-allele makes a genuine contribution toward MDD
      Title: Association between neuropeptide Y receptor Y2 promoter variant rs6857715 and major depressive disorder.
    6. not detected in infantile hemanogiomas
      Title: Neuropeptide Y receptor 1 is expressed by B and T lymphocytes and mast cells in infantile haemangiomas.
    7. polymorphisms in the NPY2R gene may be useful in identifying women at risk for osteoporosis.
      Title: Polymorphisms in neuropeptide genes and bone mineral density in Korean postmenopausal women.
    8. The C-terminal alpha-helix of Neuropeptide Y, which is formed in a membrane environment in the absence of the receptor, is unwound starting at T(32) to provide optimal contacts in a binding pocket within the transmembrane bundle of the NPY-Y2 receptor.
      Title: Unwinding of the C-Terminal Residues of Neuropeptide Y is critical for Y₂ Receptor Binding and Activation.
    9. Data show that the Y2-receptor high expression G allele is associated with a less efficient mode of action cascading where different task goals are activated in parallel.
      Title: On the relevance of the NPY2-receptor variation for modes of action cascading processes.
    10. The molecular mobility of the human neuropeptide Y receptor type 2 reconstituted into dimyristoylphosphatidylcholine (DMPC) membranes was investigated by means of solid-state NMR spectroscopy.
      Title: The G-protein-coupled neuropeptide Y receptor type 2 is highly dynamic in lipid membranes as revealed by solid-state NMR spectroscopy.
    Submit: New GeneRIF Correction See all GeneRIFs (52)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium channel regulator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables neuropeptide Y receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables peptide YY receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cardiac left ventricle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotory behavior TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in outflow tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in non-motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    neuropeptide Y receptor type 2
    Names
    NPY-Y2 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000910.4 → NP_000901.1  neuropeptide Y receptor type 2

      See identical proteins and their annotated locations for NP_000901.1

      Status: VALIDATED

      Source sequence(s)
      U36269, U42766
      Consensus CDS
      CCDS3791.1
      UniProtKB/Swiss-Prot
      P49146, Q13281, Q13457, Q4W5G7, Q6AZZ6, Q9UE67
      Related
      ENSP00000332591.3, ENST00000329476.4
      Conserved Domains (1) summary
      cd15399
      Location:51 → 336
      7tmA_NPY2R; neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001370180.1 → NP_001357109.1  neuropeptide Y receptor type 2

      Status: VALIDATED

      Source sequence(s)
      AC104407
      Consensus CDS
      CCDS3791.1
      UniProtKB/Swiss-Prot
      P49146, Q13281, Q13457, Q4W5G7, Q6AZZ6, Q9UE67
      Related
      ENSP00000426366.1, ENST00000506608.1
      Conserved Domains (1) summary
      cd15399
      Location:51 → 336
      7tmA_NPY2R; neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_001375470.1 → NP_001362399.1  neuropeptide Y receptor type 2

      Status: VALIDATED

      Source sequence(s)
      AC104407
      Consensus CDS
      CCDS3791.1
      UniProtKB/Swiss-Prot
      P49146, Q13281, Q13457, Q4W5G7, Q6AZZ6, Q9UE67
      Conserved Domains (1) summary
      cd15399
      Location:51 → 336
      7tmA_NPY2R; neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      155173723..155217076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      158505608..158548978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49146.1 GenPept UniProtKB/Swiss-Prot:P49146

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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