TRIP10 thyroid hormone receptor interactor 10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRIP10provided by HGNC
Official Full Name: thyroid hormone receptor interactor 10provided by HGNC
Primary source: HGNC:HGNC:12304
See related: Ensembl:ENSG00000125733 MIM:604504; AllianceGenome:HGNC:12304
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: STP; CIP4; HSTP; STOT; TRIP-10
Summary: Enables identical protein binding activity. Predicted to be involved in actin cytoskeleton organization; endocytosis; and signal transduction. Located in nucleoplasm. Biomarker of Huntington's disease. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in esophagus (RPKM 54.6), fat (RPKM 34.4) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.3

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (6739680..6751530)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (6729071..6740925)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (6739691..6751541)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Low expression of CIP4 in predicting worse overall survival: A potential biomarker for laryngeal cancer.
Title: Low expression of CIP4 in predicting worse overall survival: A potential biomarker for laryngeal cancer.
CIP4 PKA phosphorylation is associated with cancer cell invasiveness and metastasis.
Title: Identification of a CIP4 PKA phosphorylation site involved in the regulation of cancer cell invasiveness and metastasis.
FBP17 and CIP4 prime the membrane of resting cells for fast endophilin-mediated endocytosis by recruiting the 5'-lipid phosphatase SHIP2 and lamellipodin to mediate the local production of phosphatidylinositol-3,4-bisphosphate and endophilin pre-enrichment.
Title: FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis.
In cultured colorectal cancer (CRC) cells, knockdown of AKAP-9 inhibited cell proliferation, invasion, and migration. AKAP-9 deficiency also attenuated CRC tumor growth and metastasis in vivo. Mechanistically, AKAP-9 interacted with cdc42 interacting protein 4 (CIP4) and regulated its expression.
Title: AKAP-9 promotes colorectal cancer development by regulating Cdc42 interacting protein 4.
Data show that CIP4 is highly expressed in nasopharyngeal carcinoma (NPC) tissues and is associated with poor prognosis. Also, the study provides evidence that CIP4 plays an important role in the promotion of NPC metastasis by mediating invadopodia formation and activating the EGFR pathway.
Title: CDC42-interacting protein 4 promotes metastasis of nasopharyngeal carcinoma by mediating invadopodia formation and activating EGFR signaling.
results support a model in which AKAP350 recruits CIP4 to the centrosome, providing a centrosomal scaffold to integrate microtubule and actin dynamics, thus enabling centrosome polarization and ensuring cell migration directionality.
Title: Centrosomal AKAP350 and CIP4 act in concert to define the polarized localization of the centrosome and Golgi in migratory cells.
CIP4 promotes metastasis in Triple negative breast cancer and is associated with poor prognosis.
Title: CIP4 promotes metastasis in triple-negative breast cancer and is associated with poor patient prognosis.
CIP4 is a positive regulator of non small lung carcinoma metastasis and a potential poor prognostic biomarker in lung adenocarcinoma.
Title: CIP4 promotes lung adenocarcinoma metastasis and is associated with poor prognosis.
CIP4 controls cell-cell cohesion and is required for the acquisition of an invasive phenotype in breast tumors
Title: The CDC42-interacting protein 4 controls epithelial cell cohesion and tumor dissemination.
CIP4 plays a significant role in the intracellular hypertrophic signal transduction network that controls the growth of cardiac myocytes in heart disease.
Title: CIP4 is required for the hypertrophic growth of neonatal cardiac myocytes.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D19S618E (e-PCR)
- UniSTS:150545

RH98259 (e-PCR)
- UniSTS:91961

STS-W88625 (e-PCR)
- UniSTS:16021

RH120374 (e-PCR)
- UniSTS:132516

RH80227 (e-PCR)
- UniSTS:84718

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	NAS Non-traceable Author Statement more info	PubMed
involved_in cell communication	NAS Non-traceable Author Statement more info	PubMed
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in phagocytic cup	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cdc42-interacting protein 4

Names: TR-interacting protein 10; protein Felic; salt tolerant protein; salt tolerator; thyroid receptor-interacting protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001288962.2 → NP_001275891.1 cdc42-interacting protein 4 isoform 1

See identical proteins and their annotated locations for NP_001275891.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC008760, AF502289, AY081141, CB997985, DB198268

Consensus CDS

CCDS74271.1

UniProtKB/Swiss-Prot

B2R8A6, B7WP22, D6W645, O15184, Q15642, Q53G22, Q5TZN1, Q6FI24, Q8NFL1, Q8TCY1, Q8TDX3, Q96RJ1

UniProtKB/TrEMBL

A7VJC9

Related

ENSP00000320117.7, ENST00000313244.14

Conserved Domains (3) summary

cd07653
Location:5 → 257

F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins

cd11628
Location:395 → 475

HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like

cd11911
Location:544 → 598

SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
NM_001288963.3 → NP_001275892.1 cdc42-interacting protein 4 isoform 3

See identical proteins and their annotated locations for NP_001275892.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, and uses an alternate splice site in the 3' coding region, which leads to a frameshift, compared to variant 1. The encoded isoform (3) lacks an internal segment and has a longer and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC008760, AF380114, AK313296, AY081141, CB997985, DB198268

Consensus CDS

CCDS74272.1

UniProtKB/TrEMBL

A7VJC9, W4VSQ9

Related

ENSP00000469360.1, ENST00000596758.5

Conserved Domains (2) summary

cd07653
Location:5 → 257

F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins

cd11628
Location:339 → 419

HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
NM_004240.4 → NP_004231.1 cdc42-interacting protein 4 isoform 2

See identical proteins and their annotated locations for NP_004231.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AC008760, AK313296, AY081141, CB997985, DB198268

Consensus CDS

CCDS12172.1

UniProtKB/TrEMBL

A7VJC9

Related

ENSP00000320493.6, ENST00000313285.12

Conserved Domains (3) summary

cd07653
Location:5 → 257

F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins

cd11628
Location:339 → 419

HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like

cd11911
Location:488 → 542

SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4

RNA

NR_110231.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AB072596, AC008760, AK313296, AY081141, CB997985, DB198268

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

6739680..6751530

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006722940.2 → XP_006723003.1 cdc42-interacting protein 4 isoform X1

Conserved Domains (2) summary

cd07653
Location:5 → 257

F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins

cd11628
Location:395 → 475

HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
XM_005259683.3 → XP_005259740.1 cdc42-interacting protein 4 isoform X2

UniProtKB/TrEMBL

M0R2H7

Related

ENSP00000472580.1, ENST00000600677.5

Conserved Domains (1) summary

cd07653
Location:5 → 257

F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins