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    ZNF688 zinc finger protein 688 [ Homo sapiens (human) ]

    Gene ID: 146542, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF688provided by HGNC
    Official Full Name
    zinc finger protein 688provided by HGNC
    Primary source
    HGNC:HGNC:30489
    See related
    Ensembl:ENSG00000229809 AllianceGenome:HGNC:30489
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 4.3), fat (RPKM 3.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    16p11.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (30569726..30579951, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (30956705..30967326, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30581047..30583728, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30552221-30552866 Neighboring gene uncharacterized LOC124903677 Neighboring gene Sharpr-MPRA regulatory region 8694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:30564727-30565226 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30568583-30569144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10712 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10713 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10714 Neighboring gene zinc finger protein 764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10715 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30580811-30581376 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30581377-30581940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7379 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:30596216-30596816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7380 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30597418-30598018 Neighboring gene zinc finger protein 785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7381 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30621737-30622706 Neighboring gene uncharacterized LOC124903678 Neighboring gene zinc finger protein 689 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:30626940-30627180 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:30644787-30645738 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:30645739-30646689 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30661003-30661520 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30661521-30662036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7382 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7383 Neighboring gene proline rich 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nozawa RS, et al. Nat Cell Biol, 2010 Jul. PMID 20562864
    2. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. Loftus BJ, et al. Genomics, 1999 Sep 15. PMID 10493829
    3. N(6)-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cheng Y, et al. Cancer Cell, 2021 Jul 12. PMID 34048709, Free PMC Article
    4. Genome-scale RNAi screen for host factors required for HIV replication. Zhou H, et al. Cell Host Microbe, 2008 Nov 13. PMID 18976975
    5. Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease. Teixeira FR, et al. Biochem J, 2016 Oct 15. PMID 27503909, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of zinc finger protein 688 (ZNF688) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 688

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024683.2 → NP_001019854.1  zinc finger protein 688 isoform b

      See identical proteins and their annotated locations for NP_001019854.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
      Source sequence(s)
      AK122680, BC018997, BM011208
      Consensus CDS
      CCDS42151.1
      UniProtKB/Swiss-Prot
      P0C7X2
      Related
      ENSP00000455227.2, ENST00000563276.5
      Conserved Domains (4) summary
      sd00017
      Location:171 → 191
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:169 → 191
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:184 → 208
      zf-H2C2_2; Zinc-finger double domain
      cl00993
      Location:128 → 196
      Zn-ribbon_8; Zinc ribbon domain

    2. NM_145271.4 → NP_660314.1  zinc finger protein 688 isoform a

      See identical proteins and their annotated locations for NP_660314.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform a).
      Source sequence(s)
      AK122680, BC018997
      Consensus CDS
      CCDS10684.1
      UniProtKB/Swiss-Prot
      A8MV39, B3KV51, O75701, P0C7X2, Q8IW91, Q8WV14, Q96MN0
      UniProtKB/TrEMBL
      A0A0S2Z633
      Related
      ENSP00000223459.6, ENST00000223459.11
      Conserved Domains (4) summary
      smart00349
      Location:26 → 86
      KRAB; krueppel associated box
      sd00017
      Location:185 → 205
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:183 → 205
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:198 → 222
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      30569726..30579951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433654.1 → XP_047289610.1  zinc finger protein 688 isoform X2

    2. XM_047433653.1 → XP_047289609.1  zinc finger protein 688 isoform X1

      UniProtKB/TrEMBL
      A0A0S2Z5X4

    3. XM_005255140.3 → XP_005255197.1  zinc finger protein 688 isoform X3

      See identical proteins and their annotated locations for XP_005255197.1

      Conserved Domains (5) summary
      COG5048
      Location:82 → 158
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:108 → 128
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:106 → 128
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:121 → 145
      zf-H2C2_2; Zinc-finger double domain
      cl00993
      Location:65 → 133
      Zn-ribbon_8; Zinc ribbon domain

    4. XM_005255139.3 → XP_005255196.1  zinc finger protein 688 isoform X3

      See identical proteins and their annotated locations for XP_005255196.1

      Conserved Domains (5) summary
      COG5048
      Location:82 → 158
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:108 → 128
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:106 → 128
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:121 → 145
      zf-H2C2_2; Zinc-finger double domain
      cl00993
      Location:65 → 133
      Zn-ribbon_8; Zinc ribbon domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      30956705..30967326 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379679.1 → XP_054235654.1  zinc finger protein 688 isoform X4

    2. XM_054379681.1 → XP_054235656.1  zinc finger protein 688 isoform X2

    3. XM_054379680.1 → XP_054235655.1  zinc finger protein 688 isoform X5

    4. XM_054379682.1 → XP_054235657.1  zinc finger protein 688 isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C7X2.1 GenPept UniProtKB/Swiss-Prot:P0C7X2

    Gene LinkOut

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