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    kmt2e lysine (K)-specific methyltransferase 2E [ Danio rerio (zebrafish) ]

    Gene ID: 325395, updated on 25-Apr-2024

    Summary

    Official Symbol
    kmt2eprovided by ZNC
    Official Full Name
    lysine (K)-specific methyltransferase 2Eprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4120
    See related
    AllianceGenome:ZFIN:ZDB-GENE-030131-4120
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mll5; zgc:64223; wu:fc74b02
    Summary
    Predicted to enable metal ion binding activity. Is expressed in central nervous system and intermediate cell mass of mesoderm. Human ortholog(s) of this gene implicated in autistic disorder and cervical cancer. Orthologous to human KMT2E (lysine methyltransferase 2E (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

    Location:
    chromosome: 4
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (22424450..22473363, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (22703476..22761156, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene guanylate cyclase activator 1Aa Neighboring gene origin recognition complex, subunit 5 Neighboring gene LHFPL tetraspan subfamily member 3 Neighboring gene NADH:ubiquinone oxidoreductase subunit B2 Neighboring gene lysine (K)-specific demethylase 7Aa

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General protein information

    Preferred Names
    histone-lysine N-methyltransferase MLL5; histone-lysine N-methyltransferase 2E
    Names
    DKEY-105O6.4
    myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
    XP_005164966.1
    XP_005164967.1
    XP_009298714.1
    XP_021330941.1
    XP_692965.5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      22424450..22473363 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009300439.3XP_009298714.1  histone-lysine N-methyltransferase 2E isoform X1

      See identical proteins and their annotated locations for XP_009298714.1

      UniProtKB/TrEMBL
      A0A8M9Q6C7
      Conserved Domains (3) summary
      smart00317
      Location:344453
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd15550
      Location:129172
      PHD_MLL5; PHD finger found in mixed lineage leukemia 5 (MLL5)
      cl26464
      Location:7061046
      Atrophin-1; Atrophin-1 family
    2. XM_021475266.1XP_021330941.1  histone-lysine N-methyltransferase 2E isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q6C7
      Conserved Domains (3) summary
      smart00317
      Location:344453
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd15550
      Location:129172
      PHD_MLL5; PHD finger found in mixed lineage leukemia 5 (MLL5)
      cl26464
      Location:7061046
      Atrophin-1; Atrophin-1 family
    3. XM_005164909.4XP_005164966.1  histone-lysine N-methyltransferase 2E isoform X3

      UniProtKB/TrEMBL
      A0A8M2BC59
      Conserved Domains (2) summary
      smart00317
      Location:344453
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd15550
      Location:129172
      PHD_MLL5; PHD finger found in mixed lineage leukemia 5 (MLL5)
    4. XM_687873.8XP_692965.5  histone-lysine N-methyltransferase 2E isoform X2

      UniProtKB/TrEMBL
      A0A8N7UVB9
      Conserved Domains (2) summary
      smart00317
      Location:344453
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd15550
      Location:129172
      PHD_MLL5; PHD finger found in mixed lineage leukemia 5 (MLL5)
    5. XM_005164910.4XP_005164967.1  histone-lysine N-methyltransferase 2E isoform X4

      UniProtKB/TrEMBL
      A0A8M2BC51
      Conserved Domains (2) summary
      smart00317
      Location:344453
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd15550
      Location:129172
      PHD_MLL5; PHD finger found in mixed lineage leukemia 5 (MLL5)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_199717.1: Suppressed sequence

      Description
      NM_199717.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.