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    RASSF4 Ras association domain family member 4 [ Homo sapiens (human) ]

    Gene ID: 83937, updated on 2-May-2024

    Summary

    Official Symbol
    RASSF4provided by HGNC
    Official Full Name
    Ras association domain family member 4provided by HGNC
    Primary source
    HGNC:HGNC:20793
    See related
    Ensembl:ENSG00000107551 MIM:610559; AllianceGenome:HGNC:20793
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AD037
    Summary
    The function of this gene has not yet been determined but may involve a role in tumor suppression. Alternative splicing of this gene results in several transcript variants; however, most of the variants have not been fully described. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 36.2), fat (RPKM 31.7) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    10q11.21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (44959802..44995891)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (45840766..45876855)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (45455250..45491339)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:45304779-45305441 Neighboring gene TMEM72 antisense RNA 1 Neighboring gene eukaryotic translation initiation factor 2A pseudogene 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45324635-45325498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45348956-45349456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45374502-45375428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45403886-45404386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45404387-45404887 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:45413376-45413557 Neighboring gene transmembrane protein 72 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45427808-45428515 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45428516-45429222 Neighboring gene Sharpr-MPRA regulatory region 7362 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3314 Neighboring gene Sharpr-MPRA regulatory region 11970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3315 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3317 Neighboring gene Sharpr-MPRA regulatory region 2327 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3318 Neighboring gene uncharacterized LOC105378281 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:45467973-45468635 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:45468636-45469297 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3319 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2342 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45470934-45471637 Neighboring gene Sharpr-MPRA regulatory region 8316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45475153-45475856 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45475857-45476558 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:45479350-45479850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45486450-45487141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45487171-45487672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45487673-45488172 Neighboring gene uncharacterized LOC124902530 Neighboring gene DEPP autophagy regulator 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:45496487-45496987 Neighboring gene ZNF22 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45510141-45510640 Neighboring gene zinc finger protein 22 Neighboring gene double homeobox A pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC44914

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ras association domain-containing protein 4
    Names
    Ras association (RalGDS/AF-6) domain family 4
    Ras association (RalGDS/AF-6) domain family member 4
    Ras association domain family 4
    tumor suppressor RASSF4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032023.4 → NP_114412.2  ras association domain-containing protein 4

      See identical proteins and their annotated locations for NP_114412.2

      Status: REVIEWED

      Source sequence(s)
      AL353801, BC032593, BI601296
      Consensus CDS
      CCDS7208.1
      UniProtKB/Swiss-Prot
      Q86WH5, Q86WH6, Q86WH7, Q8N5A9, Q8TCK6, Q9H2L5
      Related
      ENSP00000339692.4, ENST00000340258.10
      Conserved Domains (1) summary
      cl00155
      Location:175 → 261
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      44959802..44995891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      45840766..45876855
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178145.1: Suppressed sequence

      Description
      NM_178145.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.